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Health Implications of Perchlorate Ingestion
TABLE 4-1 Thyroid Histopathology in Control Dams and Dams Given Four Doses of Perchlorate
Dose (mg/kg per day)
Evaluation Day and Effect
0
0.01
0.1
1.0
30.0
Gestation day 21
Colloid depletion
0/16
0/16
0/16
0/15
16/16
Follicular-cell hypertrophy
0/16
0/16
0/16
0/15
14/16
Follicular-cell hyperplasia
0/16
0/16
0/16
0/15
2/16
Postnatal day 10
Colloid depletion
0/16
1/16
1/16
5/16
16/16
Follicular-cell hypertrophy
0/16
0/16
1/16
0/16
16/16
Follicular-cell hyperplasia
0/16
0/16
1/16
2/16
9/16
Postnatal day 22
Colloid depletion
0/16
0/16
1/15
1/16
16/16
Follicular-cell hypertrophy
0/16
0/16
0/15
0/16
14/16
Follicular-cell hyperplasia
3/16
4/16
5/15
10/16
10/16
Source: Data from Argus 2001.
TABLE 4-2 Thyroid Histopathology in Control and Perchlorate-Exposed Fetuses and Pups
