TABLE 4-1 Thyroid Histopathology in Control Dams and Dams Given Four Doses of Perchlorate

 

Dose (mg/kg per day)

Evaluation Day and Effect

0

0.01

0.1

1.0

30.0

Gestation day 21

Colloid depletion

0/16

0/16

0/16

0/15

16/16

Follicular-cell hypertrophy

0/16

0/16

0/16

0/15

14/16

Follicular-cell hyperplasia

0/16

0/16

0/16

0/15

2/16

Postnatal day 10

Colloid depletion

0/16

1/16

1/16

5/16

16/16

Follicular-cell hypertrophy

0/16

0/16

1/16

0/16

16/16

Follicular-cell hyperplasia

0/16

0/16

1/16

2/16

9/16

Postnatal day 22

Colloid depletion

0/16

0/16

1/15

1/16

16/16

Follicular-cell hypertrophy

0/16

0/16

0/15

0/16

14/16

Follicular-cell hyperplasia

3/16

4/16

5/15

10/16

10/16

Source: Data from Argus 2001.

TABLE 4-2 Thyroid Histopathology in Control and Perchlorate-Exposed Fetuses and Pups

Dose (mg/kg per day)

Evaluation Day and Effect

0

0.01

0.1

1.0

30.0

Gestation day 21—Fetuses

Colloid depletion—males

0/16

2/16

0/16

12/16

16/16

Colloid depletion—females

0/16

1/16

1/16

13/16

16/16

Postnatal day 5—Pups

Colloid depletion—males

0/16

2/16

0/16

4/16

16/16

Colloid depletion—females

0/16

0/16

0/16

6/16

16/16

Postnatal day 10—Pups

Colloid depletion—males

0/16

1/16

1/16

1/16

16/16

Colloid depletion—females

0/16

0/16

1/16

4/16

15/15

Postnatal day 22—Pups

Colloid depletion—males

0/16

0/16

0/15

0/16

11/16

Colloid depletion—females

0/16

0/16

0/15

0/15

12/16

Source: Data from Argus 2001.



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