TABLE 4-3 Summary of Morphometric Findings in Rat Pups Exposed to Perchloratea

Neuroanatomic

Argus 1998

 

Argus 2001

 

EPA 2003

Region

Day 10- 12

Day 82- 85

Day 10

Day 22

Day 22

Frontal cortex

No change

Increase at high dose only in males

Increase at low or intermediate doses but not at high dose

Increase at high dose only in males

Not measured

Parietal cortex

No change

No change

Increase at low or intermediate doses but not at high dose

No change

Not measured

Striatum

Decrease at low or intermediate doses but not at high dose

Increase at high dose only in males

Increase at low or intermediate doses but not at high dose

Decrease at low or intermediate doses but not at high dose

All dose groups increased

Corpus callosum

Increase at high dose only

Increase at high dose only in males

Increase at low or intermediate doses but not at high dose in males;

Decrease at low or intermediate doses but not at high dose in females

Increase at low or intermediate doses but not at high dose

Increase at low or intermediate doses but not at high dose

Hippocampus gyrus

Decrease at low or intermediate doses but not at high dose

No change

No change

No change

Not measured

Dentate gyrus

Not measured

Not measured

No change

No change

Not measured

CA1 portion

Not measured

Not measured

Decrease at low or intermediate doses but not at high dose in females;

Increase at low or intermediate doses but not at high dose in males

No change

Not measured



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