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Health Implications of Perchlorate Ingestion (2005)
Board on Environmental Studies and Toxicology (BEST)

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. "5 Risk Characterization of Perchlorate." Health Implications of Perchlorate Ingestion. Washington, DC: The National Academies Press, 2005.

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Health Implications of Perchlorate Ingestion

Review of Selective Morphometric Data From F1 Generation Day 22 Postpartum Rats, Including New Morphometric Data Obtained From Additional Step Sections. Morphometry Review Report. Protocol 1416-003. Consultants in Veterinary Pathology, Inc., Murrysville, PA. February 3, 2003.

Crump, K., and G. Goodman. 2003. Benchmark Analysis for the Perchlorate Inhibition of Thyroidal Radioiodine Uptake Utilizing a model for the Observed Dependence of Uptake and Inhibition on Iodine Excretion. Prepared for J. Gibbs, Kerr-McGee Corporation. January 24, 2003. (Presentation at the Fifth Meeting on Assess the Health Implications of Perchlorate Ingestion, July 29-30, 2004, Washington, DC.)

EPA (U.S. Environmental Protection Agency). 2000. Benchmark Dose Technical Guidance Document, External Review Draft. EPA/630/R-00/001. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC. [Online]. Available: http://www.epa.gov/ncea/pdfs/bmds/BMDExternal_10_13_2000.pdf [accessed Nov. 17, 2004].

EPA (U.S. Environmental Protection Agency). 2002a. Perchlorate Environmental Contamination: Toxicological Review and Risk Characterization. External Review Draft. NCEA-1-0503. National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC. [Online]. Available: http://cfpub2.epa.gov/ncea/cfm/recordisplay.cfm?deid=23292 [accessed Aug. 25, 2004].

EPA (U.S. Environmental Protection Agency). 2002b. A Review of the Reference Dose and Reference Concentration Processes. Final Report. EPA/630/P-02/ 002F. Risk Assessment Forum, U.S. Environmental Protection Agency, Washington, DC. [Online]. Available: http://oaspub.epa.gov/eims/eimscomm.getfile?p_download_id=36836 [accessed Nov. 17, 2004].

EPA (U.S. Environmental Protection Agency). 2003. Disposition of Comments and Recommendations for Revisions to “Perchlorate Environmental Contamination: Toxicological Review and Risk Characterization, External Review Draft (January16,2002). [Online]. Available: http://cfpub2.epa.gov/ncea/cfm/recordisplay.cfm?deid=72117 [accessed Aug. 25, 2004].

EPA (U.S. Environmental Protection Agency). 2004. An Examination of EPA Risk Assessment Principles and Practices. EPA/100/B-04/001. Office of the Science Advisor, U.S. Environmental Protection Agency, Washington, DC. [Online]. Available: http://www.epa.gov/OSA/ratf-final.pdf [accessed Nov. 17, 2004].

Greer, M.A., G. Goodman, R.C. Pleus, and S.E. Greer. 2002. Health effects assessment for environmental perchlorate contamination: The dose response for inhibition of thyroidal radioiodine uptake in humans. Environ. Health Perspect. 110(9):927-937.

Hollowell, J.G., N.W. Staehling, W.H. Hannon, D.W. Flanders, E.W. Gunter, G.F. Maberly, L.E. Braverman, S. Pino, D.T. Miller, P.L. Garbe, D.M. DeLozier, and R.J. Jackson. 1998. Iodine nutrition in the United States. Trends and public health implications: Iodine excretion data from National Health and

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