. "2 The Thyroid and Disruption of Thyroid Function in Humans." Health Implications of Perchlorate Ingestion. Washington, DC: The National Academies Press, 2005.
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Health Implications of Perchlorate Ingestion
TABLE 2-1 24-Hour Thyroid Radioiodide Uptake in Healthy Subjects before, during, and after Oral Administration of Potassium Perchlorate for 14 Days
24-Hr Thyroid
No. of Subjects
Uptake (% of Dose) (Mean ± SE)
Uptake as % of Baseline (Mean ± SE)
P, Compared with Baseline
0.007 mg/kg-day
Baseline
7
18.1 ± 3.1
Day 14
7
16.5 ± 1.6
98.2 ± 8.3
Day 15 post-exposure
7
17.3 ± 2.5
100.3 ± 8.4
0.02 mg/kg-day
Baseline
10
18.4 ± 1.2
Day 2
8
15.7 ± 1.4
82.8 ± 5.6
<0.05
Day 14
10
15.2 ± 1.1
83.6 ± 4.1
<0.005
Day 15 post-exposure
10
19.1 ± 1.3
105.3 ± 5.5
0.1 mg/kg-day
Baseline
10
19.9 ± 2.1
Day 2
8
11.8 ± 1.7
59.2 ± 3.5
<0.005
Day 14
10
11.0 ± 1.6
55.3 ± 3.9
<0.005
Day 15 post-exposure
10
20.8 ± 2.2
106.6 ± 9.1
0.5 mg/kg-day
Baseline
10
21.6 ± 2.0
Day 2
8
6.5 ± 0.6
30.6 ± 2.6
<0.005
Day 14
10
6.9 ± 0.9
32.9 ± 3.8
<0.005
Day 15 post-exposure
10
21.7 ± 2.0
104.6 ± 9.4
Source: Greer et al. 2002.
uptake in vitro, they estimated that a daily intake of 150 µg of iodide would protect against the effects of a daily intake of 4 mg of perchlorate (0.06 mg/kg for a 70-kg person).
Serum perchlorate concentrations ranged from 0.10 to 0.17 µg/mL during administration of 0.1 mg/kg per day and from 0.45 to 0.85 µg/mL during administration of 0.5 mg/kg per day. The serum perchlorate half-life after cessation of this dose averaged 8.1 hr (range, 6.0-9.3); the half-life in the other groups could not be measured, because the values were or became undetectable very soon after perchlorate administration was stopped.
