TABLE 2-1 24-Hour Thyroid Radioiodide Uptake in Healthy Subjects before, during, and after Oral Administration of Potassium Perchlorate for 14 Days

24-Hr Thyroid

 

No. of Subjects

Uptake (% of Dose) (Mean ± SE)

Uptake as % of Baseline (Mean ± SE)

P, Compared with Baseline

0.007 mg/kg-day

Baseline

7

18.1 ± 3.1

 

 

Day 14

7

16.5 ± 1.6

98.2 ± 8.3

 

Day 15 post-exposure

7

17.3 ± 2.5

100.3 ± 8.4

 

0.02 mg/kg-day

Baseline

10

18.4 ± 1.2

 

 

Day 2

8

15.7 ± 1.4

82.8 ± 5.6

<0.05

Day 14

10

15.2 ± 1.1

83.6 ± 4.1

<0.005

Day 15 post-exposure

10

19.1 ± 1.3

105.3 ± 5.5

 

0.1 mg/kg-day

Baseline

10

19.9 ± 2.1

 

 

Day 2

8

11.8 ± 1.7

59.2 ± 3.5

<0.005

Day 14

10

11.0 ± 1.6

55.3 ± 3.9

<0.005

Day 15 post-exposure

10

20.8 ± 2.2

106.6 ± 9.1

 

0.5 mg/kg-day

Baseline

10

21.6 ± 2.0

 

 

Day 2

8

6.5 ± 0.6

30.6 ± 2.6

<0.005

Day 14

10

6.9 ± 0.9

32.9 ± 3.8

<0.005

Day 15 post-exposure

10

21.7 ± 2.0

104.6 ± 9.4

 

 

Source: Greer et al. 2002.

uptake in vitro, they estimated that a daily intake of 150 µg of iodide would protect against the effects of a daily intake of 4 mg of perchlorate (0.06 mg/kg for a 70-kg person).

Serum perchlorate concentrations ranged from 0.10 to 0.17 µg/mL during administration of 0.1 mg/kg per day and from 0.45 to 0.85 µg/mL during administration of 0.5 mg/kg per day. The serum perchlorate half-life after cessation of this dose averaged 8.1 hr (range, 6.0-9.3); the half-life in the other groups could not be measured, because the values were or became undetectable very soon after perchlorate administration was stopped.



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