FIGURES

S-1.

 

Committee’s suggested mode-of-action model for perchlorate toxicity in humans,

 

14

1-1.

 

Timeline of perchlorate-related regulatory activities,

 

21

1-2.

 

EPA’s proposed continuum of possible health effects of perchlorate exposure,

 

28

2-1.

 

Diagram of thyroid cells and thyroid follicle, showing key steps in thyroxine (T4) and triiodothyronine (T3) synthesis and secretion,

 

37

2-2.

 

Structures of thyroxine (T4), triiodothyronine (T3), and reverse triiodothyronine (reverse T3),

 

38

2-3.

 

Diagram of a cell showing pathways of thyroxine (T4) and triiodothyronine (T3) metabolism,

 

42

2-4.

 

Diagram of hypothalamic-pituitary-thyroid system,

 

44

4-1.

 

Serum thyroxine (T4), triiodothyronine (T3), and thyroid stimulating hormone (TSH) concentrations in dams treated with ammonium perchlorate at indicated doses in drinking water,

 

120

4-2.

 

Serum thyroxine (T4), triiodothyronine (T3), and thyroid stimulating hormone (TSH) concentrations in fetus and pups of dams treated with ammonium perchlorate at indicated doses in drinking water,

 

122

4-3.

 

Changes in serum T4, T3, and TSH in dams, fetuses, and pups presented as percent change from control,

 

124

4-4.

 

Parallelogram approach for using adult human, adult male rat, and female rat gestation and lactation models to estimate human equivalent exposures for human pregnancy and lactation models,

 

147

5-1.

 

Committee’s suggested mode-of-action model of perchlorate toxicity in humans,

 

166

5-2.

 

Committee’s suggested mode-of-action model for perchlorate toxicity in humans indicating first adverse effect in continuum,

 

167

5-3.

 

EPA’s summary of NOAELs and LOAELs for various health effects in rat studies,

 

171

TABLES

1-1.

 

EPA Provisional or Proposed Reference Doses (RfDs) and Corresponding Drinking Water Concentrations,

 

23



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement