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The Smallpox Vaccination Program: Public Health in an Age of Terrorism 4 Lessons Learned from the Smallpox Vaccination Program As the committee observed in its first report, the smallpox vaccination program is not a typical public health program, but rather a biopreparedness program predicated on national security considerations (IOM, 2003a). Bioterrorism preparedness is a recent addition to the scope of work of public health agencies, and it presents opportunities and challenges (such as new types of information restrictions and new domains of uncertainty) as public health agencies learn to work with national security and defense entities on matters of shared concern. The smallpox vaccination program is a case study in blending public health and national security interests to prepare for an event of low likelihood and high consequence—bioterrorism in the form of a smallpox virus release. The program will not be the last of its kind as long as terrorism, specifically bioterrorism, continues to be a threat. Therefore, discerning broad lessons to be learned from the smallpox vaccination program is important for ensuring the success of similar future programs. The present chapter highlights the committee’s major findings about the program and provides a conclusion and a recommendation based on those findings. ABSENCE OF EXPLICIT SCIENTIFIC AND PUBLIC HEALTH RATIONALE FOR THE PROGRAM In 2002, most public health officials and health care workers who participated in surveys or in several forums discussing smallpox vaccination expressed support for a limited pre-event smallpox vaccination effort and
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism willingness to be vaccinated if they were designated as members of smallpox response teams (Banks and Hannan, 2002; Everett et al., 2002; IOM, 2002; Yih et al., 2003). Yet the high degree of support for limited smallpox vaccination to prepare the nation to respond to attack did not generate a substantial turnout of volunteer vaccinees; by the end of 2004, fewer than 40,000 people had been vaccinated, far short of original estimates of turnout. The committee found several possible and related reasons for that incongruity. First, the scientific and public health rationale that led to the smallpox vaccination policy was never fully explained to key constituencies—traditional partners in the development and implementation of public health strategies, including state and local public health agencies—that provided input to the process but whose advice and perspectives were not reflected in the final policy. Although the committee recognizes that the terrorist attacks of 2001 were a dramatic and persuasive reminder of the importance of biopreparedness, it was never made clear to the public health and health care communities why smallpox was selected as a primary target for biopreparedness, how pre-event smallpox vaccination was identified as a core strategy, and why vaccination was urgent. Second, the scientific and public health rationale that led to the structure of the smallpox vaccination program (in its final form, characterized by the phases and numbers discussed elsewhere in this report) was never fully explained. The ultimate policy called for a much higher number of vaccinees than the original, cautious estimate provided to the government by the Advisory Committee on Immunization Practices (ACIP), and the rationale for offering the vaccine to 500,000 initially, then to up to 10 million, and finally to insistent members of the public was not made clear to important constituencies. Instead, confusing and contradictory information was presented to the public and the public health community about the policy and program. Third, the limited amount of information that was provided to explain the rationale for the policy and for the structure of the program was neither updated nor reiterated during the course of the program despite strong signals that updating or reiteration was needed. Fourth, program implementation was characterized by a lack of review of the program’s course and reassessment of starting assumptions. Despite calls for a pause to assess program progress and safety, the program continued. As its pace waned, there was no apparent attempt to reassess or review program implementation and its trajectory. Finally, and most centrally, the ability of the Centers for Disease Control and Prevention (CDC) to speak authoritatively as the nation’s public health leader, on the basis of the best available scientific reasoning, was severely constrained, presumably by the top levels of the executive branch.
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism Because the smallpox vaccination program involved both public health and national security considerations, it is understood that the latter could involve classified information and thus limit what could be made available to the public. However, the apparent, unexplained constraints on CDC led to an environment in which the public health and health care communities and their leaders did not receive all the information needed to make institutional and individual decisions regarding smallpox vaccination (Selecky, 2003; Smith, 2003). There is little to suggest that the scientific and public health reasoning that typically characterizes the development of public health policies was a priority in this case. The expert input of public health leaders and other relevant constituencies was not reflected in the final structure of the smallpox vaccination policy. Agencies and organizations expected to be important partners in implementing the program expressed concerns and questions about it, and those concerns ultimately affected the program’s outcomes. Key constituencies remained skeptical about the need for the program, and their lack of buy-in led to poor participation in the vaccination program. At the institutional level, this is illustrated by the request of the Association of State and Territorial Health Officials (ASTHO) for an explanation of the rationale for the program (Selecky, 2003) several months after the beginning of vaccination. Among individual public health and health care workers, receiving what they perceived as insufficient information left them unable to accept smallpox vaccination. Lack of Scientific and Public Health Rationale for the Existence of the Vaccination Program In 2003, in Health Affairs, Kuhles and Ackman wrote: The key message we received from potential vaccinees was that civilians are unlikely to voluntarily assume personal risk without good reason. Before performing an invasive procedure, physicians are required to undertake an informed-consent process with the patient, which spells out the indications, alternatives, and risks. The government owes its health care, public health, and first-responder communities the same consideration, particularly as it relates to the indications for vaccination, which thus far has been lacking. Surveys of public health and health care workers (ASTHO, 2003; Everett et al., 2002; Yih et al., 2003), interviews (Kuhles and Ackman, 2003; Markowitz and Rosner, 2004), and newspaper articles (Associated Press, 2003; Bavley and Dvorak, 2003; Connolly, 2003a; Denogean, 2003; McCullough, 2003; McNeil, 2003; Ornstein and Bonilla, 2003; Wheeler, 2003) have shown that personal decision-making about smallpox vaccination was shaped by perceptions about known and considerable vaccine risk and unknown vaccine benefit in the absence of disease. The question of
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism vaccine benefit was linked with the rationale for the vaccination program. On the basis of mass media coverage of program progress and a variety of additional sources, including presentations to the present Institute of Medicine (IOM) committee, it appears that despite the expressed sense of personal commitment (May et al., 2003) to protecting the public’s health, both individuals and institutions found the information available for decision-making inadequate in quantity and quality and ultimately not sufficiently conducive to an affirmative decision regarding vaccination. Communication about the smallpox vaccination policy and the decisions that led to it was incomplete and vague, particularly information quantifying or explaining the available evidence about the threat of smallpox and information about the epidemiologic and public health reasoning regarding whom and when to vaccinate. Although sensitive, classified information may have been involved, it does not appear that the complete facts needed for decision-making and buy-in at the state and local levels were shared with constituencies, and failure to do that had a detrimental effect on the program’s progress and, more important, may have compromised the relationship of trust between CDC and the public health community. The president’s announcement stated multiple times that the government had no information that a smallpox virus release was imminent (White House, 2002). Information provided by the Department of Health and Human Services (DHHS) and CDC largely reiterated the president’s statements and shed no additional light on the evidence that led to the decision to begin pre-event smallpox vaccination (U.S. Department of State, 2002). At least some of the information appeared to be many years old, dating back to the fall of the Soviet Union (Gellman, 2002), and it was never made clear to the public what accumulation of evidence made smallpox vaccination an urgent priority. The president’s announcement that the threat was not imminent, although not zero, restated what had been the case for at least a decade. Undoubtedly, the events of September and October 2001 were important in shaping how old information was being viewed (White House, 2002). A complete risk-benefit analysis in the face of extreme ambiguity seemed impossible, and both institutional and personal decisions regarding vaccination were complicated by the lack of information. The factual information available to institutions and individuals considering participation in the voluntary vaccination program consisted primarily of the following: The president’s statement about the threat assessment. The statements of other federal officials (including the director of CDC) about the threat assessment. The recent occurrence of domestic terrorism and bioterrorism.
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism The immediacy of war with a nation that the administration asserted had weapons of mass destruction, including biologic weapons. Historical evidence about the vaccine. Historical evidence about the disease. The provisions of Section 304 of the Homeland Security Act. The resulting sense of uncertainty proved to be problematic. As one clinician stated, the perceived lack of evidence regarding a possible smallpox virus release was a deterrent to vaccination. “It is not enough for someone—whether it is the president or the secretary of state—to say, ‘I’m worried about this; trust me’…. We need more than that today as a profession and as a society,” he observed (Connolly, 2003a). In a presentation to this committee, the president of a large health and hospital system stated (Anderson, 2003) that he did not believe he had the evidence to support the vaccination of “even the core 100 [vaccinees]. It was our concern that there was evidence that we didn’t have, that we weren’t being given, or it wasn’t being shared, that something was more serious here than we thought. Maybe there was a weaponized product, that somebody had broken through, and that we weren’t being told about.” The hospital epidemiologist of a university health system stated (Edmond, 2003) that “we didn’t want the decision to vaccinate to be one that was ideological. We wanted it to be an evidence-based decision.” On the basis of the information available to it, the leadership of that university health system developed an institutional policy to undertake only planning for postevent vaccination and to implement smallpox vaccination only in any of three scenarios: if a smallpox case occurred anywhere in the world, if information were provided by the federal or state government about a serious smallpox risk, or if smallpox stocks were found outside the two approved repositories. Representatives of a large health plan also listed among problems with the program the perception that the case for smallpox vaccination was “never sufficiently compelling” and that the uncertainty surrounding the policy and program created distress and skepticism among staff (Skivington and Witt, 2003). Finally, interviews conducted with health officials and other public health experts in the early months of the program’s implementation indicated that some did not believe that a convincing case had been made to justify the pre-event vaccination program (Kuhles and Ackman, 2003; Markowitz and Rosner, 2004). The Input of Key Constituencies The committee’s knowledge of the circumstances surrounding the development of the policy is derived primarily from official CDC and DHHS transcripts of press conferences, testimony before Congress, presentations
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism at IOM committee meetings, and, to a lesser extent, mass media reports (when multiple reports corroborating an event were available). During the development of the smallpox vaccination policy, there was communication among CDC, DHHS, the Office (later the Department) of Homeland Security, and the White House (Cohen and Enserink, 2002). Multiple constituencies (including various entities in the health care, public health, and first responder communities) provided written and oral input to CDC and to Congress (for example, at CDC-organized forums across the nation) in the months before the policy was developed and during its implementation. For example, during summer 2002, CDC engaged its state and local partners (such as representatives of ASTHO and the Council of State and Territorial Epidemiologists) in numerous discussions and provided multiple opportunities for comment about the policy options being considered (ASTHO, 2002; CDC, 2002a; IOM, 2002). In June 2002, ASTHO held a conference call and then conducted a survey to determine its members’ views on strategies for smallpox preparedness. The survey found that a majority of state health officials were opposed to pre-event vaccination of the general public, but most supported pre-event vaccination of designated response teams (Banks and Hannan, 2002). Consensus reached at the June 2002 ACIP meeting reflected a similar opposition to pre-event vaccination of the general public and support for vaccination of specific groups of responders (CDC, 2002b). The ultimate policy decision on vaccinating members of the general public and on vaccinating health care workers differed from the consensus of key constituencies, and it is unclear to what extent their expertise and input were considered. The collaborative nature of public health in the United States, described in the IOM report The Future of the Public’s Health in the 21st Century, makes partnership and communication essential to any program’s success. Within that process, the credibility of information and decisions from the national level sets the stage for all later decisions and actions by state and local health departments and their partners. Not knowing what evidence was considered and not receiving information about it from CDC—as evidenced by the fact that key partners, such as ASTHO, requested clarification (to the committee’s knowledge never provided) of the rationale behind the policy and the structure of the program—may have affected the public health community’s trust in CDC, as is evident in the expressed perceptions and concerns of many in the public health and health care communities (ASTHO, 2003; Pendley, 2003; Markowitz and Rosner, 2004). A recent CDC analysis of the swine influenza vaccination program of 1976 noted the importance of ensuring the credibility of decisions made by CDC (DHHS, 2004). The Neustadt and Fineberg analysis (1983) of the swine flu program also concluded that the program demonstrated an “insensitivity to the long-term credibility of institutions.”
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism The final vaccination policy differed considerably from the recommendations of public health leaders and other important constituencies, and those groups were left with questions about the rationale for the vaccination program. That contrasts with the implementation of more typical public health programs and with the principles of public health practice. First, the ethos of public health attaches great importance to the empower-ment and participation of a broad constituency in decision-making; a high degree of openness and collaboration also is consistent with the democratic principle of public accountability (Gostin, 1995). Second, effective policy-making requires identifying potential obstacles, and those are likely to be known or anticipated by key constituencies. The implementation of the vaccination program reveals missed opportunities at the level of policy-making to identify or adequately address potential obstacles to implementation (discussed in Chapter 3). For example, in addition to unease about compensation and liability issues, state and local public health agencies expressed concern that implementing a vaccination program of massive proportions, beyond the initial 500,000 vaccinees, would have safety implications and enormous resource requirements (Connolly, 2002; Hardy 2002; Libbey, 2003a, 2003b; Rosado, 2003). That the policy was not consistent with the recommendations of key constituencies and its rationale was not clearly and adequately explained to them may also have led to difficulties in balancing competing priorities. For example, the vaccination program’s single-agent focus and great resource requirements burdened the public health system to the detriment of other public health activities, including the routine activities of public health and preparedness for other kinds of emergencies. Smallpox efforts were all-consuming for many local public health agencies, especially smaller health departments. Despite the bioterrorism grants that had been made available to states, state and local public health officials expressed frustration at the program’s vast underestimation of its direct and opportunity costs and argued that the vaccination program necessitated a diversion from bioterrorism plans that they had already developed in anticipation of funding (ASTHO, 2003; Cook, 2003; GAO, 2003; Kuhles and Ackman, 2003; Markowitz and Rosner, 2004; NACCHO, 2003a, 2003b; Staiti et al., 2003; U.S. House of Representatives, 2004). Of local public health agencies surveyed by the National Association of County and City Health Officials (NACCHO) in March 2003, 79 percent reported that smallpox activities adversely affected their other bioterrorism preparedness efforts (NACCHO, 2003a). County health officials also reported on opportunity costs of diverting staff to smallpox activities and on delaying or deferring other public health programs (Kuhles and Ackman, 2003; Madlock, 2003; Nikolai, 2003; NACCHO, 2003b; Markowitz and Rosner, 2004; U.S. House of Representatives, 2004). As one county public health agency struggled with
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism a tuberculosis outbreak, its efforts were complicated by the fact that its resources were greatly strained by a combination of budget cuts and the demands of the smallpox vaccination program. Other local health departments reported diverting staff from their regular activities, delays in childhood immunizations, cancelled family planning clinics, cuts in tobacco control and maternal and child health services, and other changes or cuts in services routinely provided by public health agencies (Connolly, 2003b; Cook, 2003; Hughes, 2003; Staiti et al., 2003). Planning for the smallpox vaccination program appears not to have included sufficient analysis of the potential effect of vaccination activities on the provision of essential public health services and on other preparedness efforts or analysis of the added costs of implementing such a large vaccination program (GAO, 2003; IOM, 2003b, 2003c). It remains unclear to what extent the supplementary funding provided by DHHS in May 2003 ameliorated the fiscal challenges experienced by some jurisdictions. Lack of Scientific and Public Health Rationale for the Structure of the Vaccination Program The rationale for the program’s structure also was not fully explained. As discussed in Chapter 3, ACIP’s June 2002 recommendation to CDC and DHHS called for the vaccination of up to 20,000 people: public health personnel who would serve on smallpox public health investigation teams and health care personnel staffing designated “smallpox hospitals” (CDC, 2002b). John Modlin, ACIP chair, acknowledged the group’s unease with the unknown risk of smallpox virus release, but he believed that its recommendation to DHHS and CDC was made carefully. “The committee has been told that the risk is low but not zero. We obviously can’t put a number on that but we … assume that it’s low, and I think the decision that we made … balanced that low or very low risk with … the known risk from the vaccine” (CDC, 2002c). In October 2002, after the mass media had reported on the various figures being considered by the administration, one of which was 500,000 vaccinees, ACIP revised its recommendation in recognition that hospitals would probably resist being designated as smallpox hospitals and, more important, that smallpox-stricken persons would go to the nearest emergency department rather than to a designated location (Altman, 2002; Brown, 2002; CDC, 2002b; Cohen and Enserink, 2002). ACIP’s revised vaccination target was 500,000. The ACIP chair acknowledged that that was a “back-of-the-envelope” calculation based on the assumption that if the nation’s roughly 5,100 acute-care hospitals each vaccinated roughly 100 people, the total would be about a half-million vaccinated health care workers. That may explain in part how the target for the first phase of the program was derived, although to some the 500,000
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism figure seemed oddly coincidental with the estimate first suggested by White House officials, and there was some initial concern that ACIP was pressured to modify its earlier recommendation (Brown, 2002; Cohen and Enserink, 2002) (see also discussion in Chapter 2). The rationale for the second and third phases of the program, vaccinating 10 million responders and insistent members of the general public, respectively, which surpassed and even diverged from ACIP recommendations and from the advice of constituencies such as the American Public Health Association, the American Academy of Family Physicians, the Emergency Nurses Association, and others that called for limited vaccination (AAFP, 2002; APHA, 2002; ENA, 2002; IDSA, 2002; May et al., 2003), was never shared with those who would implement the program or who would volunteer to be vaccinated. There was no apparent public health reasoning behind the decision to offer vaccine to the public. In fact, the present committee stated in its fourth report to CDC that “offering vaccination to members of the general public is contrary to the basic precepts of public health ethics, which focus on a fair and reasonable balance of risks and benefits among individuals and for the population as a whole” (IOM, 2003b; see Appendix E). The nation’s public health and health care communities expected an explanation of the public health reasoning behind the policy that would include an epidemiologic justification for offering vaccination to the three types of vaccinees identified, evidence that vaccinating response teams before a smallpox virus release would ensure a better and faster response to an attack, evidence that vaccinating other types of responders (such as firefighters and police) would substantially improve response effectiveness, and evidence that implementing specific pre-event vaccination activities would be an optimal use of resources as part of bioterrorism preparedness efforts. The committee is unaware of evidence showing whether and how the advantages and disadvantages of various pre-event vaccination options were carefully weighed and compared or evidence that decisions were made accordingly. Confusing and Contradictory Information About the Policy and the Program The contradictory and confusing information provided during the implementation of the smallpox vaccination program may have constituted another barrier to implementation of the program and may have undermined CDC’s credibility further. For example, the announcement of the policy and later explanations assured Americans that there was no imminent risk of smallpox virus release (U.S. Department of State, 2002; White House, 2002). Nevertheless, the federal government repeatedly called for rapid implementation of the vaccination program. CDC’s initial guidance
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism to the states called for implementing vaccination within 30 days (CDC, 2002d). After the program began, representatives of the public health community remarked on the challenging timeline and called for slower implementation (Hardy, 2002; Libbey, 2003a, 2003b). Although the initial 30-day timeline was later changed and CDC acknowledged that flexibility would be needed because of administrative difficulties and variation among states, CDC continued to call for rapid implementation without specifying the reason (CDC, 2003a, 2003c; Ornstein and Bonilla, 2003; Russell, 2003). CDC’s emphasis on safety and speed seemed contradictory and generated confusion and an atmosphere of near-crisis in which public health agencies at all levels felt compelled to undertake smallpox vaccination activities about which they had doubts (ASTHO, 2003; Connolly, 2003b; Cook, 2003; McKenna, 2003; NACCHO, 2003a; Pezzino, 2003). In addition, owing to the remarkable speed with which the program was implemented, a number of administrative and procedural components were not ready for implementation, as discussed in greater detail in Chapter 3. Although impending crisis would have justified a rapid response, that was not the case that was made. Instead, the rush to vaccinate as many personnel as possible as rapidly as possible gave rise to concerns about the wisdom of exposing people to an unsafe vaccine in the absence of a known threat of disease. As described in Chapter 3, the present IOM committee and ASTHO urged CDC to pause after the first phase of vaccination to assess program safety and to plan for the next phase, and ACIP recommended terminating the program because of the occurrence of cardiac adverse events and their unknown long-term safety ramifications (CDC, 2003d; IOM, 2003d; Meckler, 2003a). The present committee repeated its call for a pause in the vaccination program in another report in which that was the primary recommendation (IOM, 2003b); however, despite its acknowledgment of the importance of safety, CDC stated that it expected the program to progress seamlessly from one phase to the next, at least in part to maintain momentum (Henderson, 2003; McGlinchey, 2003a). It is not clear whether CDC discussed the merits and costs of a pause in the vaccination program with its state and local counterparts. In the end, multiple state and local programs paused or stalled simply for lack of volunteer vaccinees. Lack of Updating or Reiteration of the Rationale The juxtaposition of impending war with the uncertainty surrounding the rationale for the vaccination policy and the lack of information pertaining to the smallpox threat assessment may have contributed to the program’s slow progress. In January and February 2003, simultaneously with the implementation of smallpox vaccination, the administration was demonstrating to the nation and international allies that a war in Iraq was neces-
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism sary to prevent the use of weapons of mass destruction. That clearly contentious matter was debated in Congress, in the mass media, and elsewhere. An attack on Iraq was argued on security, economic, foreign relations, military, and other grounds. Although the federal government did not explicitly link the war with Iraq and the vaccination program and at times even denied that the rationale for the program was related to the rationale for the war, several officials (DHHS Secretary Thompson, CDC Director Gerberding, and CDC National Immunization Program Director Walt Orenstein) and legislators (Senators Bill Frist and Judd Gregg) made statements that could be interpreted as suggesting that the war was a factor in the decisions made about the smallpox vaccination policy and program or as asserting the importance of vaccination in view of developments related to the war and the possibility of a bioterrorrist attack (Frist, 2002; Gregg, 2002; Hallow, 2002; Manning and Sternberg, 2002; Pear, 2003; Rath and Turcotte, 2003; Tanner, 2003; Washington Post, 2002). Whether formally linked with the war or not, by its timing the smallpox vaccination policy was caught up in the larger debate with its emotional and polarizing consequences. Similarly, there was debate in some quarters about the efficacy and necessity of the vaccination program. According to the April 2003 General Accounting Office (GAO, now the Government Accountability Office) report, and to local health officials, hospital administrators, and others who were interviewed by the media or who addressed this committee, many people concluded that the risk of a smallpox attack was associated with the contentious war with Iraq (Anderson, 2003; Judson, 2003; Kuhles and Ackman, 2003; Krupnick, 2003; Manning, 2003; McKenna, 2003; McNeil, 2003). As the weeks passed, major combat in Iraq ended; the homeland security threat level, which had been increased before the war, was lowered; and the smallpox threat did not materialize. In September 2003, the U.S.-led Iraq Survey Group reported that it did not find weapons of mass destruction in Iraq; in particular, the group found no evidence of smallpox (Linzer, 2003; CIA, 2004; UN Security Council, 2004). Unfortunately, the smallpox threat assessment was neither updated nor reiterated, and that left many prospective volunteers in the public health and health care communities to draw their own conclusions about the threat status and may have further eroded their trust, given what they were (or were not) hearing from their federal-level partners. Those factors may have contributed to a waning sense of urgency; combined with concerns about cardiac adverse events, they go far to explain the declining rate of vaccination. At the May 2003 meeting of the present IOM committee, ASTHO summarized what the nation’s health officials considered requirements for advancing smallpox preparedness, including a definition of the full scope of smallpox preparedness, a national consensus on who should be asked to
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism nation was essential for preparedness (CDC, 2003a). Not until several weeks into the program did CDC state that “preparedness is not numbers,” echoing statements made by ASTHO and by the present IOM committee (Cook, 2003; IOM, 2003d; Kuhles and Ackman, 2003; NACCHO, 2003a; Selecky, 2003). Months into the program, when CDC attempted to reorient program focus toward the full scope of preparedness, the efforts were perceived as an attempt to divert attention from a troubled program (McGlinchey, 2003b). The pattern of confusing vaccination numbers with preparedness continued. In 2004, the DHHS secretary responded to a question about the status of smallpox vaccination, stating that “we would like to be able to keep increasing that vaccination number, so that every state is ready” and perhaps reinforcing the perception that numbers were a correlate of readiness (DHS, 2004). Despite the late effort to differentiate preparedness and vaccination, the committee has determined that many people and institutions were able to distinguish between the two. For example, public health agencies worked on training staff, developing communication plans, and other preparedness activities while hospital administrators who decided not to receive or implement vaccination at the time continued to work on planning, training, education, and other elements of preparedness (Edmond, 2003; Selecky, 2003; Toomey, 2003). There are other challenges to the claim that preparedness was the program goal from the beginning. If preparedness, not numbers, was the program’s focus, the frenetic pace of vaccination imposed at the beginning of the program was not needed. If the program had all along been about preparedness and not about numbers of vaccinees, CDC could have decided to delay the program because of concerns about compensation, the states could have been encouraged to proceed with their planning, training and education, and related preparedness efforts while deferring vaccination until compensation and other issues were resolved. The federal government’s single-minded and intense focus on vaccination and vaccination targets also imposed great burdens on public health agencies that may have affected not just the routine work of the agencies (the Ten Essential Public Health Services) but their ability to develop comprehensive smallpox preparedness in the context of bioterrorism preparedness. Is the Nation More Prepared Against Smallpox? It is unclear whether smallpox preparedness has been strengthened. Government officials have said that preparedness has been improved, but the committee is not aware of the evidence that such readiness has been reached. That type of evidence, properly communicated, is critical to reassure the public that local, state, and federal public health agencies have the
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism equipment, staff, and other resources to mount an effective response to an attack that uses smallpox virus. Smallpox preparedness also has broader implications for other types of preparedness. For example, the capacity to implement mass vaccination requires many of the plans and resources that are needed to implement mass distribution of other types of countermeasures, from iodine tablets to anthrax prophylaxis. At the committee’s November 2003 meeting, the director of CDC’s Office of Terrorism Preparedness and Emergency Response (OTPER), Joseph Henderson, presented the agency’s efforts to define and measure public health preparedness, including smallpox preparedness. CDC had developed 4 preparedness goals, 22 objectives, and 127 indicators, 10 of which specifically addressed smallpox preparedness. CDC intended the indicators to serve as a way to “scorecard” preparedness nationally and state by state and as a way to evaluate compliance with grant guidance (Henderson, 2003). This IOM committee was asked to review the smallpox preparedness indicators (in the context of the larger bioterrorism indicators project) and to advise CDC on their appropriateness and on ways to determine when an indicator had been met. The committee devoted its fifth report, included here as Appendix F, to a review of the indicators and included an assessment of relevant constituencies (state and local public health agencies, health care professionals, health care institutions, and first responders), whose input was solicited at the November 2003 meeting. In that report, the committee stated that preparedness for public health emergencies (including a potential smallpox event) should be part of overall continuous quality improvement of the public health system (IOM, 2003e). CDC appears to have continued its work on the performance indicators; but at the time the present report was being written, no indicators or other assessment tool had been implemented. In May 2004, at the meeting of the DHHS secretary’s Council on Public Health Preparedness, a CDC official stated that efforts to develop assessment tools were continuing and summarized CDC’s Evidence-Based Performance Goals for Public Health Disaster Preparedness—42 performance goals and 47 measures (Knutson, 2004). In July 2004, at the CDC–American Medical Association First National Congress on Public Health Readiness, the director of CDC’s OTPER noted that CDC’s Evidence-Based Performance Goals for Public Health Disaster Preparedness—more recently, consisting of 35 performance goals and 45 measures—would be available for review on August 31, 2004 (Schable, 2004). The committee is unaware of the current status of the performance goals and measures. On the basis of available information, the committee has concluded that the nation’s smallpox preparedness has not yet been formally, systematically, and comprehensively evaluated. Therefore, if the smallpox vaccination effort was in fact part of a larger preparedness pro-
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism gram, it is unclear whether the effort succeeded in strengthening preparedness. An early program objective was to build the capacity of every state to vaccinate its entire population within 10 days of a smallpox virus release. Although an ASTHO survey has found that most states believe they are prepared to complete mass vaccination within 10 days and the DHHS secretary has stated that most states “could vaccinate every person … within 10 days, and that’s our goal” (DHS, 2004), there are no data to confirm that states and the nation as a whole would be able to accomplish that. Furthermore, defining preparedness is still a necessity because it is unclear what information has been used to determine that 10 days was an appropriate target. The window of opportunity for smallpox prophylaxis is believed to be 3-4 days after exposure (CIDRAP and IDSA, 2004). If so, aiming to vaccinate all within 10 rather than 3 days would probably be insufficient for the prevention of next-generation cases if exposure were widespread—and certainly insufficient to avert public concern about whether everyone can obtain protection if needed. After nearly 2 years of great effort, considerable expenditures, and the smallpox vaccination of nearly 40,000 people, the nation remains with insufficient evidence that it is prepared to respond to a smallpox virus release. In fact, the delay evidenced in the response to the monkeypox outbreak (CDC was informed of the outbreak 13 days after its start), which could be considered a proxy for a bioterrorist attack, indicates that considerable gaps in preparedness remain (Mitchell, 2003). The committee recommends that, in collaboration with its state and local partners and in the context of broad bioterrorism preparedness, CDC define smallpox preparedness; set goals that reflect the best available scientific and public health reasoning; conduct regular, comprehensive assessments of preparedness at the national level and by state; and communicate to the public about the status of preparedness efforts. This will inform and reassure Americans about the public health system’s ability to protect their health and will help jurisdictions continuously improve and learn from the process of preparing for public health emergencies, including smallpox virus release. CONCLUDING OBSERVATIONS Trust is a unifying theme among the committee’s findings. The committee asserts that a relationship of trust between CDC and the public health and health care communities is a critical requirement in the implementation of biopreparedness programs. When a policy has the potential to greatly affect the public’s health, an explanation of the evidence base and rationale that led to the policy becomes necessary to justify and mobilize public
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism health action. The rationale of the smallpox vaccination program was never adequately explained to key constituencies and communication with CDC was constrained by unknown factors. As a result, the public health and health care communities seemed unable to trust the government and CDC fully when they called for smallpox vaccination in large numbers and at a rapid pace. The pace of vaccination ultimately declined, and the number of vaccinees reached fell far short of initial expectations. CDC’s credibility has been recognized to be an important asset. The role of CDC as the nation’s public health leader—providing scientific and public health reasoning to inform the process of policy-making and to explain the rationale for policy to key constituencies—must be safeguarded. The reality and perception of CDC’s independence to communicate openly and transparently came into question during the implementation of the smallpox vaccination program. It is essential to preserve the public health and health care communities’ trust in CDC’s leadership; therefore, when reasons of national security limit CDC’s ability to perform its role, that fact should be made explicit and public. The trust of the general public in government and government’s ability to protect the public’s health also is a critical requirement for responding to bioterrorism (and other public health threats). Communication experts (Covello and Sandman, 2001; Sandman, 2002) and a recent survey (Lasker, 2004) have shown that people’s trust in the government must be handled with great care, but it is an essential requirement for effective communication; people are less likely to panic and more likely to participate constructively during an emergency if they believe they can trust government agencies to provide accurate and timely information. The public’s confidence in the public health system’s capacity to protect people in a bioterrorism event efficiently and effectively depends on evidence and reassurance that CDC and the nation’s public health agencies are prepared. Although considerable resources and effort have been invested in the smallpox vaccination program, it remains unclear whether the nation is more prepared than it was before to respond to an attack with smallpox virus; preparedness has not been defined, clear goals have not been set, and there has been no comprehensive and systematic assessment of smallpox preparedness. Such an assessment is necessary to demonstrate that the nation is prepared and to communicate that to the public. Since the eighteenth century, American governments at all levels have determined that public health is an appropriate concern. The history of the agencies established shows regular debates about the array of activities to be expected and the degree to which decision makers and the public agree with the rationale that prompts action. Decisions about regulation of drinking water, protection of the food chain, immunization of children, and many other matters reflect those concerns. Without a regular exchange of
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism trustworthy information and clarity of rationale, the ability of the public health community to act decisively when needed is compromised. The committee believes that it is crucial for the highest level of the executive branch of the federal government to examine the consequences of the unclear rationale for the smallpox vaccination policy and for CDC itself to undertake a careful and transparent analysis of the problems encountered by the smallpox vaccination program, from problems with implementation to the lack of known outcomes. Only such an effort, in collaboration with public health partners at the state and local levels, can lay the foundation for a preparedness program that can build on the trust so central to a public health community and can reassure the public that the nation’s public health system is prepared to protect their health. REFERENCES AAFP (American Academy of Family Physicians). 2002. Panel calls for limited smallpox vaccination. FP Report 8(8). Altman L. 2002, August 25. Health Workers Await Official Smallpox Policy. New York Times. Anderson R. 2003. Presentation Before the IOM Committee on Smallpox Vaccination Program Implementation. Transcript of Meeting Three on May 1, 2003, Washington, DC. APHA (American Public Health Association). 2002. News Release: APHA Calls for Measured, Deliberate Approach to Smallpox Vaccinations. [Online] Available at http://www.apha.org/news/press/2002/smallpoxresponse.htm. Accessed December 13, 2002. Associated Press. 2003, February 1. State Begins Smallpox Inoculations. Billings [Montana] Gazette. ASTHO (Association of State and Territorial Health Officials). 2002. 2002 Infectious Diseases Committee Annual Report—September. [Online] Available at http://www.astho.org/?template=_infectious_disease_committee.html. ASTHO. 2003. ASTHO Smallpox Preparedness Survey Results (April 25, 2003). [Online] Available at http://www.astho.org/pubs/spxsummaryb2.pdf. Accessed July 7, 2003. Banks S, Hannan C. 2002. ASTHO Ensures State Health Officials Are Heard in Smallpox Debate. [Online] Available at http://astho.org/templates/displau_pub.php?pub_id=336. Bavley A, Dvorak J. 2003, February 8. Safety Concerns Hinder Participation in Smallpox Vaccination Program. Kansas City Star. Brown D. 2002, October 17. Panel Alters Advice on Smallpox Shots: Wider Use for Health Workers Backed. Washington Post, A3. CDC (Centers for Disease Control and Prevention). 2002a, May 30. Media Advisory: Smallpox Public Forums. [Online] Available at www.cdc.gov/od/oc/media/pressrel/a020530.htm. Accessed January 31, 2005. CDC. 2002b. Centers for Disease Control and Prevention, National Immunization Program Record of the Meeting of the Advisory Committee on Immunization Practices, June 19-20, 2002, Atlanta, GA. CDC. 2002c. CDC Telebriefing Transcript, June 20, 2002: Smallpox Vaccine. [Online] Available at http://www.cdc.gov/od/oc/media/transcripts/t020620.htm. Accessed January 31, 2005.
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism CDC. 2002d. Supplemental Guidance for Planning and Implementing the National Smallpox Vaccination Program (NSVP), November 22, 2002. [Online] Available at http://www.bt.cdc.gov/agent/smallpox/vaccination/pdf/supplemental-guidance-nsvp.pdf. CDC. 2003a. CDC Telebriefing Transcript, January 17, 2003: CDC Smallpox Vaccination Update. [Online] Available at http://www.cdc.gov/od/oc/media/transcripts/t030117.htm. Accessed August 6, 2004. CDC. 2003b. CDC Telebriefing Transcript: Update on Monkeypox and Severe Acute Respiratory Syndrome (SARS) Investigations. [Online] Available at http://www.cdc.gov/od/oc/media/transcripts/t030619.htm. Accessed July 5, 2003. CDC. 2003c. CDC Telebriefing Transcript: Smallpox Vaccine Adverse Events Monitoring and Response System. [Online]. Available at http://www.cdc.gov/od/oc/media/transcripts/t030206.htm. Accessed March 11, 2003. CDC. 2003d. Advisory Committee on Immunization Practices (ACIP) Statement on Smallpox Preparedness and Vaccination. [Online]. Available at http://www.bt.cdc.gov/agent/smallpox/vaccination/pdf/acipjun2003.pdf. Accessed July 17, 2003. CDC. 2003e. CDC Telebriefing Transcript: Safer, Healthier Summer. [Online] Available at http://www.cdc.gov/od/oc/media/transcripts/t030626.htm. Accessed July 1, 2003. CDC. 2004. About CDC. [Online] Available at http://www.cdc.gov/aboutcdc.htm. Accessed December 17, 2004. CIA (Central Intelligence Agency). 2004. Comprehensive Report of the Special Advisor to the Director of Central Intelligence on Iraq’s WMD. [Online] Available at http://www.cia.gov/cia/reports/iraq_wmd_2004/. CIDRAP (Center for Infectious Disease Research and Policy) and IDSA (Infectious Diseases Society of America). 2004. Smallpox: Current, Comprehensive Information on Pathogenesis, Microbiology, Diagnosis, Treatment, and Prophylaxis. [Online] Available at http://www.cidrap.umn.edu/cidrap/content/bt/smallpox/biofacts/smllpx-summary.html. Cohen J, Enserink M. 2002. Rough-and-tumble behind Bush’s smallpox policy. Science 298:2312-2316. Connolly C. 2002, December 24. Smallpox Plan May Force Other Health Cuts. Washington Post, A1. Connolly C. 2003a, February 24. Bush Smallpox Inoculation Near Standstill; Medical Professionals Cite Possible Side Effects, Uncertainty of Threat. Washington Post, A6. Connolly C. 2003b, March 10. Smallpox Campaign Taxing Health Resources. Washington Post, A4. Cook R. 2003, April 5. Smallpox Planning Detracts from Core Public Health, Officials Say. Associated Press. Covello V, Sandman P. 2001. Risk Communication: Evolution and Revolution. Baltimore, MD: Johns Hopkins University Press, pp. 164-178. Denogean AT. 2003, February 3. Health Officials Weigh Smallpox Vaccinations Pros, Cons. Tucson [Arizona] Citizen. Local News. DHHS (Department of Health and Human Services). 2004. Appendix 11: Lessons Learned from 1976 Swine Influenza Program—Draft. In Draft Pandemic Influenza Preparedness and Response Plan. [Online] Available at http://www.hhs.gov/nvpo/pandemicplan/annex11.swineflu.pdf. Accessed August 30, 2004. DHS (Department of Homeland Security). 2004. Press Conference, January 29, 2004: Bio-Surveillance Program Initiative Remarks by Secretary of Homeland Security Tom Ridge and Secretary of Health and Human Services Secretary Tommy Thompson. Edmond M. 2003. Presentation Before the IOM Committee on Smallpox Vaccination Program Implementation. Transcript of Meeting Three on May 1, 2003, Washington, DC.
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism ENA (Emergency Nurses Association). 2002. Letter to President George W. Bush. December 12, 2002. [Online] Available at http://www.ena.org/news/news/SmallpoxLetter.htm. Accessed December 16, 2002. Everett W, Coffin S, Zaoutis T, Halpern S, Kim J, Strom B. 2002. Smallpox Willingness: A National Study of Emergency Department Personnel. Presentation Before the IOM Committee on Smallpox Vaccination Program Implementation on December 19, 2002. Fauci AS. 2002. Smallpox vaccination policy—the need for dialogue. New England Journal of Medicine 346(17):1319-1320. Fiorill J. 2003, October 24. US Smallpox Official Acknowledges Vaccination “Targets Were Not Achieved”. Global Security Newswire. Frist B. 2002, August 9. Deciding Who Is Protected Against Smallpox. New York Times. GAO (General Accounting Office). 1977. The Swine Flu Program: An Unprecedented Venture in Preventive Medicine. Washington, DC: HRD-77-115. GAO. 2003. Smallpox Vaccination: Implementation of National Program Faces Challenges. Washington, DC: General Accounting Office, GAO-03-578. Gellman B. 2002, November 5. Findings Spur New Smallpox Concerns. Albany (NY) Times Union. Gostin L. 1995. The Formulation of Policy by the Three Branches of Government. In IOM, Society’s Choices: Social and Ethical Decision-Making. Washington, DC: National Academy Press. Gregg J. 2002, October 6. Let the Public Choose on Smallpox Vaccine. Washington Post. Gursky E. 2003. Progress and Peril: Bioterrorism Preparedness Dollars and Public Health. Century Foundation. [Online] Available at http://www.tcf.org/Publications/HomelandSecurity/Gursky_Progress_Peril.pdf. Accessed January 30, 2005. Hallow R. 2002, November 24. Governors Seek Access to Smallpox Vaccine. Washington Times, A4. Hardy G. 2002. Statement of the Association of State and Territorial Health Officials. Presentation Before the IOM Committee on Smallpox Vaccination Program Implementation, Meeting One on December 19, 2002, Washington, DC. Henderson J. 2003. Presentation Before the IOM’s Committee on Smallpox Vaccination Program Implementation. Transcript of Meeting Three on May 1, 2003, Washington, DC. Hughes C. 2003, September 28. Public Health Programs Feared Lost in New Battle. Albany (NY) Times Union. IDSA (Infectious Diseases Society of America). 2002. Letter to President George W. Bush. December 3, 2002. [Online] Available at http://www.idsociety.org. IOM (Institute of Medicine). 2002. Scientific and Policy Considerations in Developing Smallpox Vaccination Options: A Workshop Report. Washington, DC: The National Academies Press IOM. 2003a. Review of the Centers for Disease Control and Prevention’s Smallpox Vaccination Program Implementation: Letter Report #1. Washington, DC: The National Academies Press. IOM. 2003b. Review of the Centers for Disease Control and Prevention’s Smallpox Vaccination Program Implementation: Letter Report #4. Washington, DC: The National Academies Press. IOM. 2003c. Review of the Centers for Disease Control and Prevention’s Smallpox Vaccination Program Implementation: Letter Report #2. Washington, DC: National Academies Press. IOM. 2003d. Review of the Centers for Disease Control and Prevention’s Smallpox Vaccination Program Implementation: Letter Report #3. Washington, DC: The National Academies Press.
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism IOM. 2003e. Review of the Centers for Disease Control and Prevention’s Smallpox Vaccination Program Implementation: Letter Report #5. Washington, DC: The National Academies Press. Judson F. 2003. Presentation Before the IOM Committee on Smallpox Vaccination Program Implementation. Transcript of Meeting Three on May 1, 2003, Washington, DC. Kemper V. 2003, February 6. Smallpox Vaccine Hits a Snag: Compensation. Los Angeles Times, 18. Knutson D. 2004. State and Local Terrorism Preparedness and Emergency Response: Status Update, Presentation to the Secretary’s Council on Public Health Preparedness, May 4, 2004. Krupnick M. 2003, January 24. CNA Calls Smallpox Program “Political.” Nursing Union Official Says Bush’s Plan Carries More Risks Than Benefits. Contra Costa Times, A1. Kuhles D, Ackman D. 2003. The federal smallpox vaccination program: where do we go from here? Health Affairs (Web Exclusive) W3:503-510. Lasker R. 2004. Redefining Readiness: Terrorism Planning Through the Eyes of the Public. New York: New York Academy of Medicine, Center for the Advancement of Collaborative Strategies in Health. Libbey P. 2003a. Statement of Patrick M. Libbey, Executive Director National Association of County and City Health Officials. Presentation Before the Secretary’s Council on Public Health Preparedness, January 14, 2003. [Online] Available at http://www.naccho.org/advocacydoc650.cfm. Accessed January 31, 2005. Libbey P. 2003b. Testimony of Patrick M. Libbey, Executive Director, National Association of County and City Health Officials Before the Senate Appropriations Committee: Senate Labor, Health and Human Services and Education Appropriations Subcommittee. Linzer D. 2003, September 18. No Evidence Iraq Stockpiled Smallpox. Associated Press. Madlock Y. 2003. Presentation Before the IOM Committee on Smallpox Vaccination Program Implementation. Transcript of Meeting Three on May 1, 2003, Washington, DC. Manning A. 2003, April 22. Second Round of Smallpox Vaccinations Begins. USA Today. Manning A, Sternberg S. 2002, October 7. Officials Ponder Timing, Sequence of Immunizations. USA Today. Markowitz G, Rosner D. 2004. Smallpox Campaign and Population Health Programs Emergency Preparedness, Bioterrorism, and the States: The First Two Years After September 11. New York: Milbank Memorial Fund. May T, Aulisio MP, Silverman RD. 2003. The Smallpox Vaccination of Health Care Workers: Professional Obligations and Defense Against Bioterrorism. Hastings Center Report September-October 2003. McCullough M. 2003, February 7. Americans Aren’t Rolling Up Their Sleeves for Smallpox Inoculation. The Salt Lake Tribune. McGlinchey D. 2003a, February 26. CDC Says It Never Aimed for 500,000 Smallpox Vaccinations. Global Security Newswire. McGlinchey D. 2003b, November 19. CDC Director Denies Existence of Smallpox Immunization Program. GovExec.Com. McKenna M. 2003, February 15. No Vaccination for Nation’s Fear; Unease Hinders Smallpox Program. Atlanta Journal-Constitution. McNeil D. 2003, February 7. Many Balking at Vaccination for Smallpox. New York Times. Meckler L. 2003a, February 22. Smallpox Vaccinations Off to Slow Start. Associated Press. Meckler L. 2003b, July 17. CDC: Smallpox May Still Be a Threat. Associated Press. Mitchell S. 2003, June 12. Monkeypox Shows Gap in Bioterror Readiness. United Press International. NACCHO (National Association of County and City Health Officials). 2003a. Impact of Smallpox Vaccination Program on Local Public Health Services. Research Brief No. 9.
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism NACCHO. 2003b. Costs of Smallpox Vaccination Program: Summary of Preliminary Data. Research Brief No. 10. National Press Club. 2003. National Press Club Luncheon with Dr. Julie Gerberding, Centers for Disease Control and Prevention, November 14, 2003. Neustadt R, Fineberg H. 1983. The Epidemic That Never Was: Policy-making and the Swine Flu Affair. New York: Vintage Books. Neustadt RE, Fineberg HF. 1978. The Swine Flu Affair: Decision-making on a Slippery Disease. U.S. Department of Health, Education, and Welfare. Nikolai K. 2003. Presentation Before the IOM Committee on Smallpox Vaccination Program Implementation. Transcript of Meeting Three on May 1, 2003, Washington, DC. Ornstein C, Bonilla D. 2003, February 6. Fifteen in the County Refuse Vaccinations for Employees. Nine Accept; Most Are Undecided. Los Angeles Times. Pear R. 2003, March 7. Threats and Responses: Biological Defense Officials Seek Smallpox Compensation Fund. New York Times, A15. Pendley L. 2003. Commentary: Smallpox Vaccinations Prompt Questions. Santa Fe New Mexican, A7. Pezzino G. 2003. Presentation Before the IOM Committee on Smallpox Vaccination Program Implementation. Transcript of Meeting Three on May 1, 2003, Washington, DC. Rath E, Turcotte J. 2003. Press Release, March 6, 2003: Senator Gregg to Move Smallpox Compensation Legislation Through Senate. Office of Judd Gregg, U.S. Senator for New Hampshire. Roos R. 2003, May 14. In Funding Guidelines, HHS Urges States to Press on with Smallpox Efforts. CIDRAP News. Rosado E. 2003. Fact Sheet: Smallpox. National Association of Counties. [Online] Available at http://www.naco.org/ContentManagement/ContentDisplay.cfm?ContentID=7042. Accessed January 31, 2005. Russell S. 2003, January 18. Smallpox Vaccine Plan Starts Tuesday, Despite Concerns; Some Health Workers May Opt Out Over Risks, Compensation Issues. San Francisco Chronicle. Sandman PM. 2002. Smallpox Vaccination: Some Risk Communication Linchpins. [Online] Available at http://www.spsandman.com/col/smallpox.htm. Accessed January 31, 2003. Schable C. 2004. Readiness: Where Are We? Where Do We Need to Be? Presentation to the CDC-AMA First National Congress on Public Health Readiness, July 22, 2004. [Online] Available at http://www.ama-assn.org/ama/noindex/category/11053.html. Accessed January 31, 2005. Selecky M. 2003. Presentation Before the IOM Committee on Smallpox Vaccination Program Implementation. Transcript of Meeting Three on May 1, 2003, Washington, DC. Shockman L. 2003, March 28. Nationwide Smallpox Protection Program for Health Workers Is Shy of Goal. Toledo [Ohio] Blade. Skivington S, Witt D. 2003. Kaiser Permanente Smallpox Vaccination Implementation Overview. Slide presentation before the IOM Committee on Smallpox Vaccination Program Implementation, May 1, 2003. Smith S. 2003. Smallpox vaccination: national security & individual risk. Virtual Mentor (American Medical Association Ethics Resource Center) 5(2). Staiti A, Katz A, Hoadley J. 2003. Has Bioterrorism Preparedness Improved Public Health? Center for Studying Health System Change, Issue Brief: Findings from HSC No. 65. Tanner L. 2003. CDC Encourages Health Workers at Conference to Get Smallpox Shots. Associated Press. Toomey K. 2003. Presentation Before the IOM Committee on Smallpox Vaccination Program Implementation. Transcript of Meeting Two on February 13, 2003, Washington, DC.
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The Smallpox Vaccination Program: Public Health in an Age of Terrorism UN (United Nations) Security Council. 2004. Nineteenth Quarterly Report on the Activities of the United Nations Monitoring, Verification and Inspection Commission in Accordance with Paragraph 12 of Security Council Resolution 1284 (1999). Geneva: United Nations, S/2004/924. [Online] Available at http://www.un.org/Depts/unmovic/new/documents/quarterly_reports/s-2004-924.pdf. Accessed February 14, 2005. U.S. Department of State. 2002. White House Press Briefing (Officials Detail Smallpox Vaccination Plans; Will Consider Vaccination Requests from Allies and Friends.). U.S. Department of State, Office of International Information Programs. U.S. House of Representatives. 2004. U.S. Representative Thomas M. Davis (R-VA) Holds Hearing on Health System Preparedness. House Government Reform Committee. Available from Federal Document Clearing House, Inc, via Lexis-Nexis. U.S. House of Representatives Select Committee on Homeland Security (Democratic Members). 2004. A Biodefense Failure: The Smallpox Vaccination Program One Year Later. [Online] Available at http://www.house.gov/hsc/democrats/pdf/press/040129_ABiodefenseFailureOneYearLater.pdf. Accessed February 2004. U.S. Senate Select Committee on Intelligence. 2004. Report on the U.S. Intelligence Community’s Prewar Intelligence Assessments on Iraq. [Online] Available at http://intelligence.senate.gov/iraqreport2.pdf. Washington Post. 2002. Voluntary Smallpox Vaccination Urged. Offer to General Population Represents a Shift in Policy. Washington Post, A1. Wheeler T. 2003, February 6. Medical Workers Leery of Smallpox Vaccine. Beacon Journal [Ohio]. White House. 2002. President Delivers Remarks on Smallpox. [Online]. Available at http://www.whitehouse.gov/news/releases/2002/12/20021213-7.html. Accessed January 8, 2003. Yih W, Lieu T, Rego V, O’Brien M, Shay D, Yokoe D, Platt R. 2003. Attitudes of healthcare workers in U.S. hospitals regarding smallpox vaccination. BMC Public Health 3(20):20.
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