TABLE A-2 Epidemiologic Studies—Environmental Exposure

Reference

Study Design

Description

Study Group (N)

Comparison Group (N)a

New Studies from Seveso

Baccarelli et al., 2004

Population based

mRNA concentrations, AhR, ARNT, CYP1A1, CYP1B1 genes, and EROD activity in peripheral blood lymphocytes in a Seveso, Italy cohort

62

59

Eskenazi et al., 2004

Cohort

Relationship between serum TCDD concentration and age at exposure in SWHS participatants

899

None

Eskenazi et al., 2003a

Cohort

Association between maternal serum TCDD and birth outcome SWHS participants

888

None

Landi et al., 2003

Population based

Effect of TCDD-mediated alterations in AhR-dependent pathway in Seveso zone A and B residents

62

59

Baccarelli et al., 2002

Population based

Immunologic effects in Seveso residents, compared with previous published results

62

59

Eskenazi et al., 2002a

Cohort

Association between menstrual cycle characteristics and serum TCDD in SWHS participatants

381

None

Eskenazi et al., 2002b

Cohort

Association between endometriosis and serum TCDD concentration in SWHS participants

601

None

Studies from Seveso Reviewed in Update 2002

Warner et al., 2002

Cohort

Study to evaluate the association between individual serum TCDD levels and breast cancer risk in women who participated in the SWHS

15

981



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