Description of Study

Evidence Class (Comments)

Results

Reference

Multicenter, double-blind randomized trial comparing different MP doses (1,000 versus 100 mg/d for 11 d) for treatment of 330 ASCI patients (NASCIS I study)

III (study design, data presentation, interpretation, and analysis flaws)

No treatment effect at 6 wk and 6 mo postinjury, no control group

Bracken et al. (1984)

1-yr follow-up of NASCIS I study

III (study design, data presentation, interpretation, and analysis flaws)

No significant difference in neurological recovery of motor or sensory function at 1 yr postinjury

Bracken et al. (1985)

Multicenter, randomized, double-blind, placebo-controlled trial comparing MP treatment with naloxone and placebo treatment in 487 patients (NASCIS II study)

III (study design, data presentation, interpretation, and analysis flaws)

Significant improvement in motor change scores (P = 0.03) and sensation change scores (P = 0.02) at 6 mo postinjury for patients treated with MP within 8 h of injury

Bracken et al. (1990)

1-yr follow-up of NASCIS II study

III (study design, data presentation, interpretation, and analysis flaws)

Significant improvement in motor change scores 1 yr postinjury for patients treated with MP within 8 h of injury (P = 0.03); administration of MP was detrimental if it was given more than 8 h after injury

Bracken et al. (1992)



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