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Spinal Cord Injury: Progress, Promise, and Priorities (2005)

Chapter: Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003

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Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
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G
SPINAL CORD INJURY CLINICAL TRIALS PUBLISHED FROM 1998 TO 2003

To identify the spinal cord injury clinical trials that were published from 1998 to 2003, Institute of Medicine staff searched Medline using the relevant medical subject headings as search terms and limiting the searches by publication types relevant to clinical trials. Additional clinical trial terms, namely, “randomized controlled trial,” “controlled,” “placebo,” “double-blind,” and “prospective,” were also used in the search strategy.

The titles and abstracts were reviewed to determine the clinical conditions and outcomes that were addressed in each article. Table G-1 categorizes the clinical trials by the primary outcome(s) examined and secondarily is organized in chronological order. The majority of clinical trials targeted secondary complications that arise as a result of a spinal cord injury and did not directly test therapies to improve lost function. Articles that addressed multiple conditions (e.g., the effects of bowel and bladder functions on the quality of life) were counted once in each category and are designated with an asterisk.

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

TABLE G-1 Spinal Cord Injury Clinical Trials, 1998 to 2003

Topic and Author(s)

Study Title

Journal Reference

Acute Care

Spinal Cord Injury Thromboprophylaxis Investigators (2003)*

Prevention of venous thromboembolism in the acute treatment phase after spinal cord injury: A randomized, multicenter trial comparing low-dose heparin plus intermittent pneumatic compression with enoxaparin.

Journal of Trauma: Injury Infection & Critical Care 54(6): 1116-1124

Geisler et al. (2001)

The Sygen multicenter acute spinal cord injury study.

Spine 26(24 Suppl): S87-98

Matsumoto et al. (2001)

Early complications of high-dose methylprednisolone sodium succinate treatment in the follow-up of acute cervical spinal cord injury.

Spine 26(4): 426-430

Mcllvoy et al. (2000)

Use of an acute spinal cord injury clinical pathway.

Critical Care Nursing Clinics of North America 12(4): 521-530

Pointillart et al. (2000)

Pharmacological therapy of spinal cord injury during the acute phase.

Spinal Cord 38(2): 71-76

Prasad et al. (1999)

Characteristics of injuries to the cervical spine and spinal cord in polytrauma patient population: Experience from a regional trauma unit.

Spinal Cord 37(8): 560-568

Selden et al. (1999)*

Emergency magnetic resonance imaging of cervical spinal cord injuries: Clinical correlation and prognosis.

Neurosurgery 44(4): 785-792

Shepard et al. (1999)*

Magnetic resonance imaging and neurological recovery in acute spinal cord injury: Observations from the National Acute Spinal Cord Injury Study 3.

Spinal Cord 37(12): 833-837

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Bracken et al. (1998)*

Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial.

Journal of Neurosurgery 89(5): 699-706

Petitjean et al. (1998)

Medical treatment of spinal cord injury in the acute stage.

Annales Francaises d Anesthesie et de Reanimation 17(2): 114-122

Segal et al. (1998)

Methylprednisolone disposition kinetics in patients with acute spinal cord injury.

Pharmacotherapy 18(1): 16-22

Xiong et al. (1998)

Manipulation for cervical spinal dislocation under general anesthesia: Serial review for 4 years.

Spinal Cord 36(1): 21-24

Alternative Therapy

Wong et al. (2003)

Clinical trial of acupuncture for patients with spinal cord injuries.

American Journal of Physical Medicine & Rehabilitation 82(1): 21-27

Zemper et al. (2003)

Assessment of a holistic wellness program for persons with spinal cord injury.

American Journal of Physical Medicine & Rehabilitation 82(12): 957-968

Diego et al. (2002)

Spinal cord patients benefit from massage therapy.

International Journal of Neuroscience 112(2): 133-142

Dyson-Hudson et al. (2001)*

Acupuncture and Trager psychophysical integration in the treatment of wheelchair user’s shoulder pain in individuals with spinal cord injury.

Archives of Physical Medicine and Rehabilitation 82(8): 1038-1046

Honjo et al. (2000)*

Acupuncture on clinical symptoms and urodynamic measurements in spinalcord-injured patients with detrusor hyperreflexia.

Urologia Internationalis 65(4): 190-195

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Cheng et al. (1998)*

A therapeutic trial of acupuncture in neurogenic bladder of spinal cord injured patients: A preliminary report.

Spinal Cord 36(7): 476-480

Bladder-Bowel

Abrams et al. (2003)

Tamsulosin: Efficacy and safety in patients with neurogenic lower urinary tract dysfunction due to suprasacral spinal cord injury.

Journal of Urology 170 (4 Pt 1): 1242-1251

Kim et al. (2003)

Intravesical resiniferatoxin for refractory detrusor hyperreflexia: A multicenter, blinded, randomized, placebo-controlled trial.

Journal of Spinal Cord Medicine 26(4): 358-363

Laessoe et al. (2003)*

Effects of ejaculation by penile vibratory stimulation on bladder capacity in men with spinal cord lesions.

Journal of Urology 169(6): 2216-2219

Lazzeri et al. (2003)

Urodynamic effects of intravesical nociceptin/orphanin FQ in neurogenic detrusor overactivity: A randomized, placebo-controlled, double-blind study.

Urology 61(5): 946-950

O’Leary et al. (2003)

Effect of controlled-release oxybutynin on neurogenic bladder function in spinal cord injury.

Journal of Spinal Cord Medicine 26(2): 159-162

Reitz et al. (2003)

Afferent fibers of the pudendal nerve modulate sympathetic neurons controlling the bladder neck.

Neurourology & Urodynamics 22(6): 597-601

Schmid et al. (2003)*

Clinical value of combined electrophysiological and urodynamic recordings to assess sexual disorders in spinal cord injured men.

Neurourology & Urodynamics 22(4): 314-321

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Xiao et al. (2003)

An artificial somatic-central nervous system-autonomic reflex pathway for controllable micturition after spinal cord injury: Preliminary results in 15 patients.

Journal of Urology 170(4 Pt 1): 1237-1241

Chartier-Kastler et al. (2002)

Intrathecal catheter with subcutaneous port for clonidine test bolus injection. A new route and type of treatment for detrusor hyperreflexia in spinal cord-injured patients.

European Urology 37(1): 14-17

Cosman et al. (2002)

Topical lidocaine does not limit autonomic dysreflexia during anorectal procedures in spinal cord injury: A prospective, double-blind study.

International Journal of Colorectal Disease 17(2): 104-108

Krogh et al. (2002)

Efficacy and tolerability of prucalopride in patients with constipation due to spinal cord injury.

Scandinavian Journal of Gastroenterology 37(4): 431-436

Rodic et al. (2002)*

Magnetic stimulation of sacral roots for assessing the efferent neuronal pathways of lower urinary tract.

Muscle & Nerve 26(4): 486-491

Sesay et al. (2002)*

Autonomic hyperreflexia induced by sacral root stimulation is detected by spectral analysis of the EEG.

Canadian Journal of Anaesthesia 49(9): 936-941

Tsai et al. (2002)

Treatment of detrusor-sphincter dyssynergia by pudendal nerve block in patients with spinal cord injury.

Archives of Physical Medicine and Rehabilitation 83(5): 714-717

Creasey et al. (2001)

An implantable neuroprosthesis for restoring bladder and bowel control to patients with spinal cord injuries: A multicenter trial.

Archives of Physical Medicine and Rehabilitation 82(11): 1512-1519

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Giannantoni et al. (2001)

Intermittent catheterization with a prelubricated catheter in spinal cord injured patients: A prospective randomized crossover study.

Journal of Urology 166(1): 130-133

Hohenfellner et al. (2001)

Sacral bladder denervation for treatment of detrusor hyperreflexia and autonomic dysreflexia.

Urology 58(1): 28-32

Kirkham et al. (2001)

The acute effects of continuous and conditional neuromodulation on the bladder in spinal cord injury.

Spinal Cord 39(8): 420-428

Reid et al. (2001)

Cranberry juice consumption may reduce biofilms on uroepithelial cells: Pilot study in spinal cord injured patients.

Spinal Cord 39(1): 26-30

Chen et al. (2000)

Current trend and risk factors for kidney stones in persons with spinal cord injury: A longitudinal study.

Spinal Cord 38(6): 346-353

Christensen et al. (2000)

Neurogenic colorectal dysfunction—use of new antegrade and retrograde colonic wash-out methods.

Spinal Cord 38(4): 255-261

Haferkamp et al. (2000)

Dosage escalation of intravesical oxybutynin in the treatment of neurogenic bladder patients.

Spinal Cord 38(4): 250-254

Honjo et al. (2000)*

Acupuncture on clinical symptoms and urodynamic measurements in spinalcord-injured patients with detrusor hyperreflexia.

Urologia Internationalis 65(4): 190-195

Hull et al. (2000)

Urinary tract infection prophylaxis using Escherichia coli 83972 in spinal cord injured patients.

Journal of Urology 163(3): 872-877

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Kao et al. (2000)

Using technetium-99M dimercaptosuccinic acid renal cortex scintigraphy to differentiate acute pyelonephritis from other causes of fever in patients with spinal cord injury.

Urology 55(5): 658-662

Pannek et al. (2000)

Combined intravesical and oral oxybutynin chloride in adult patients with spinal cord injury.

Urology 55(3): 358-362

Reid et al. (2000)

Ofloxacin for the treatment of urinary tract infections and biofilms in spinal cord injury.

International Journal of Antimicrobial Agents 13(4): 305-307

Sakakibara et al. (2000)

Pressure-flow study as an evaluating method of neurogenic urethral relaxation failure.

Journal of the Autonomic Nervous System 80(1-2): 85-88

Biering-Sorensen et al. (1999)

Urethral epithelial cells on the surface on hydrophilic catheters after intermittent catheterization: Cross-over study with two catheters.

Spinal Cord 37(4): 299-300

Chancellor et al. (1999)

Sphincteric stent versus external sphincterotomy in spinal cord injured men: Prospective randomized multicenter trial.

Journal of Urology 161(6): 1893-1898

Chancellor et al. (1999)

Long-term follow-up of the North American multicenter UroLume trial for the treatment of external detrusor-sphincter dyssynergia.

Journal of Urology 161(5): 1545-1550

Chiou-Tan et al. (1999)

Increased norepinephrine levels during catheterization in patients with spinal cord injury.

American Journal of Physical Medicine & Rehabilitation 78(4): 350-353

Juan Garcia et al. (1999)

Intraurethral stent prosthesis in spinal cord injured patients with sphincter dyssynergia.

Spinal Cord 37(1): 54-57

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Michielsen et al. (1999)

Management of false passages in patients practicing clean intermittent self catheterization.

Spinal Cord 37(3): 201-203

Plancke et al. (1999)

Indiana pouch in female patients with spinal cord injury.

Spinal Cord 37(3): 208-210

Stohrer et al. (1999)

Efficacy and safety of propiverine in SCI-patients suffering from detrusor hyperreflexia—a double-blind, placebo-controlled clinical trial.

Spinal Cord 37(3): 196-200

Virseda Chamorro et al. (1999)

Evidence-based medicine. Usefulness of isolated cystomanometry for the diagnosis of periurethral detrusor-sphincter dyssynergia in patients with suprasacral lesion.

Archivos Espanoles de Urologia 52(10): 1073-1078

Walter et al. (1999)

Bioavailability of trospium chloride after intravesical instillation in patients with neurogenic lower urinary tract dysfunction: A pilot study.

Neurourology & Urodynamics 18(5): 447-453

Cheng et al. (1998)*

A therapeutic trial of acupuncture in neurogenic bladder of spinal cord injured patients—A preliminary report.

Spinal Cord 36(7): 476-480

Dasgupta et al. (1998)

Treating the human bladder with capsaicin: Is it safe?

European Urology 33(1): 28-31

De Looze et al. (1998)

Constipation and other chronic gastrointestinal problems in spinal cord injury patients.

Spinal Cord 36(1): 63-66

Denys et al. (1998)

Intrathecal clonidine for refractory detrusor hyperreflexia in spinal cord injured patients: A preliminary report.

Journal of Urology 160(6 Pt 1): 2137-2138

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

de Seze et al. (1998)

Capsaicin and neurogenic detrusor hyperreflexia: A double-blind placebo-controlled study in 20 patients with spinal cord lesions.

Neurourology & Urodynamics 17(5): 513-523

Everaert et al. (1998)

Diagnosis and localization of a complicated urinary tract infection in neurogenic bladder disease by tubular proteinuria and serum prostate specific antigen.

Spinal Cord 36(1): 33-38

Giannantoni et al. (1998)

Clean intermittent catheterization and prevention of renal disease in spinal cord injury patients.

Spinal Cord 36(1): 29-32

Hamamci et al. (1998)

A quantitative study of genital skin flora and urinary colonization in spinal cord injured patients.

Spinal Cord 36(9): 617-620

Horton et al. (1998)

Does refrigeration of urine alter culture results in hospitalized patients with neurogenic bladders?

Journal of Spinal Cord Medicine 21(4): 342-347

Kajio et al. (1998)

Clinical features of transurethral anterior sphincterotomy and urological management of patients with cervical spinal cord injury.

Nippon Hinyokika Gakkai Zasshi (Japanese Journal of Urology) 89(11): 885-893

Low et al. (1998)

Use of the Memokath for detrusor-sphincter dyssynergia after spinal cord injury: A cautionary tale.

Spinal Cord 36(1): 39-44

Moser et al. (1998)

Antibodies to urinary tract pathogens in patients with spinal cord lesions.

Spinal Cord 36(9): 613-616

Previnaire et al. (1998)

Is there a place for pudendal nerve maximal electrical stimulation for the treatment of detrusor hyperreflexia in spinal cord injury patients?

Spinal Cord 36(2): 100-103

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Stiens et al. (1998)

Polyethylene glycol versus vegetable oil based bisacodyl suppositories to initiate side-lying bowel care: A clinical trial in persons with spinal cord injury.

Spinal Cord 36(11): 777-781

Sutton et al. (1998)

Continent ileocecal augmentation cystoplasty.

Spinal Cord 36(4): 246-251

Vaidyananthan et al. (1998)

Effect of intermittent urethral catheterization and oxybutynin bladder instillation on urinary continence status and quality of life in a selected group of spinal cord injury patients with neuropathic bladder dysfunction.

Spinal Cord 36(6): 409-414

Bone Density

Jones et al. (2002)*

Intensive exercise may preserve bone mass of the upper limbs in spinal cord injured males but does not retard demineralisation of the lower body.

Spinal Cord 40(5): 230-235

Banovac et al. (2001)

Prevention of heterotopic ossification after spinal cord injury with indomethacin.

Spinal Cord 39(7): 370-374

Warden et al. (2001)

Efficacy of low-intensity pulsed ultrasound in the prevention of osteoporosis following spinal cord injury.

Bone 29(5): 431-436

de Bruin et al. (2000)

Estimation of geometric properties of cortical bone in spinal cord injury.

Archives of Physical Medicine and Rehabilitation 81(2): 150-156

Kiratli et al. (2000)

Bone mineral and geometric changes through the femur with immobilization due to spinal cord injury.

Journal of Rehabilitation Research & Development 37(2): 225-233

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Liu et al. (2000)*

Quantitative computed tomography in the evaluation of spinal osteoporosis following spinal cord injury.

Osteoporosis International 11(10): 889-896

Sautter-Bihl et al. (2000)

Radiotherapy as a local treatment option for heterotopic ossifications in patients with spinal cord injury.

Spinal Cord 38(1): 33-36

Middleton et al. (1999)*

Postural control during stance in paraplegia: Effects of medially linked versus unlinked knee-ankle-foot orthoses.

Archives of Physical Medicine and Rehabilitation 80(12): 1558-1565

Nance et al. (1999)

Intravenous pamidronate attenuates bone density loss after acute spinal cord injury.

Archives of Physical Medicine and Rehabilitation 80(3): 243-251

Jaovisidha et al. (1998)

Influence of heterotopic ossification of the hip on bone densitometry: A study in spinal cord injured patients.

Spinal Cord 36(9): 647-653

Low et al. (1998)

Bone mineral status after pediatric spinal cord injury.

Spinal Cord 36(9): 641-646

Wing et al. (1998)

Risk of avascular necrosis following short term megadose methylprednisolone treatment.

Spinal Cord 36(9): 633-636

Cardiovascular

Chiou-Tan et al. (2003)

Comparison of dalteparin and enoxaparin for deep venous thrombosis prophylaxis in patients with spinal cord injury.

American Journal of Physical Medicine & Rehabilitation 82(9): 678-685

Ethans et al. (2003)*

The effects of sildenafil on the cardiovascular response in men with spinal cord injury at or above the sixth thoracic level.

Journal of Spinal Cord Medicine 26(3): 222-226

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Spinal Cord Injury Thromboprophylaxis Investigators (2003)

Prevention of venous thromboembolism in the rehabilitation phase after spinal cord injury: Prophylaxis with low-dose heparin or enoxaparin.

Journal of Trauma: Injury Infection & Critical Care 54(6): 1111-1115

Spinal Cord Injury Thromboprophylaxis Investigators (2003)*

Prevention of venous thromboembolism in the acute treatment phase after spinal cord injury: A randomized, multicenter trial comparing low-dose heparin plus intermittent pneumatic compression with enoxaparin.

Journal of Trauma: Injury Infection & Critical Care 54(6): 1116-1124

Wakana et al. (2003)

Effects of 4-aminopyridine on cardiac repolarization, PR interval, and heart rate in patients with spinal cord injury.

Pharmacotherapy 23(2): 133-136

Yoo et al. (2003)

Cardiovascular responses to endotracheal intubation in patients with acute and chronic spinal cord injuries.

Anesthesia & Analgesia 97(4): 1162-1167

Gates et al. (2002)*

Absence of training-specific cardiac adaptation in paraplegic athletes.

Medicine & Science in Sports & Exercise 34(11): 1699-1704

Sesay et al. (2002)*

Autonomic hyperreflexia induced by sacral root stimulation is detected by spectral analysis of the EEG.

Canadian Journal of Anaesthesia 49(9):936-941

Cooke et al. (2001)

Cardiovascular effects of vasopressin following V(1) receptor blockade compared to effects of nitroglycerin.

American Journal of Physiology—Regulatory Integrative & Comparative Physiology 281(3): R887-893

Gerrits et al. (2001)*

Peripheral vascular changes after electrically stimulated cycle training in people with spinal cord injury.

Archives of Physical Medicine and Rehabilitation 82(6): 832-839

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Houtman et al. (2001)

Changes in cerebral oxygenation and blood flow during LBNP in spinal cord-injured individuals.

Journal of Applied Physiology 91(5): 2199-2204

Legramante et al. (2001)*

Positive and negative feedback mechanisms in the neural regulation of cardiovascular function in healthy and spinal cord-injured humans.

Circulation 103(9): 1250-1255

Lohmann et al. (2001)

Prevention of thromboembolism in spinal fractures with spinal cord injuries. Standard heparin versus low-molecular-weight heparin in acute paraplegia.

Zentralblatt für Chirurgie 126(5): 385-390

Tsuji et al. (2001)*

Evaluation of spinal cord blood flow during prostaglandin E1-induced hypotension with power Doppler ultrasonography.

Spinal Cord 39(1): 31-36

Averill et al. (2000)*

Blood pressure response to acupuncture in a population at risk for autonomic dysreflexia.

Archives of Physical Medicine and Rehabilitation 81(11): 1494-1497

Sipski et al. (2000)*

Sildenafil effects on sexual and cardiovascular responses in women with spinal cord injury.

Urology 55(6): 812-815

Yamasaki et al. (2000)

Effect of acute heat exposure on skin blood flow of the paralyzed thigh in persons with spinal cord injury.

Spinal Cord 38(4): 224-228

Kjaer et al. (1999)*

Heart rate during exercise with leg vascular occlusion in spinal cord-injured humans.

Journal of Applied Physiology 86(3): 806-811

Roussi et al. (1999)

Contribution of D-dimer determination in the exclusion of deep venous thrombosis in spinal cord injury patients.

Spinal Cord 37(8): 548-552

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Hopman et al. (1998)*

Blood redistribution and circulatory responses to submaximal arm exercise in persons with spinal cord injury.

Scandinavian Journal of Rehabilitation Medicine 30(3): 167-174

Pruitt et al. (1998)*

Health behavior in persons with spinal cord injury: Development and initial validation of an outcome measure.

Spinal Cord 36(10): 724-731

Schmid et al. (1998)*

Physical performance and cardiovascular and metabolic adaptation of elite female wheelchair basketball players in wheelchair ergometry and in competition.

American Journal of Physical Medicine & Rehabilitation 77(6): 527-533

Cough

Lin et al. (1999)

Cough threshold in people with spinal cord injuries.

Physical Therapy 79(11): 1026-1031

Lin et al. (1998)*

Effects of an abdominal binder and electrical stimulation on cough in patients with spinal cord injury.

Journal of the Formosan Medical Association 97(4): 292-295

Lin et al. (1998)*

Functional magnetic stimulation for restoring cough in patients with tetraplegia.

Archives of Physical Medicine and Rehabilitation 79(5): 517-522

Exercise and Locomotion

Eser et al. (2003)*

Influence of different stimulation frequencies on power output and fatigue during FES-cycling in recently injured SCI people.

IEEE Transactions on Neural Systems & Rehabilitation Engineering 11(3): 236-240

Gagnon et al. (2003)*

Biomechanical analysis of a posterior transfer maneuver on a level surface in individuals with high and low-level spinal cord injuries.

Clinical Biomechanics 18(4): 319-331

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Goldfarb et al. (2003)*

Preliminary evaluation of a controlled-brake orthosis for FES-aided gait.

IEEE Transactions on Neural Systems & Rehabilitation Engineering 11(3): 241-248

Harvey et al. (2003)

Randomised trial of the effects of four weeks of daily stretch on extensibility of hamstring muscles in people with spinal cord injuries.

Australian Journal of Physiotherapy 49(3): 176-181

Hicks et al. (2003)*

Long-term exercise training in persons with spinal cord injury: Effects on strength, arm ergometry performance and psychological well-being.

Spinal Cord 41(1): 34-43

Schalow et al. (2003)

High-load coordination dynamics in athletes, physiotherapists, gymnasts, musicians and patients with CNS injury.

Electromyography & Clinical Neurophysiology 43(6): 353-365

Scivoletto et al. (2003)

A prototype of an adjustable advanced reciprocating gait orthosis (ARGO) for spinal cord injury (SCI).

Spinal Cord 41(3): 187-191

Stein et al. (2003)*

A wheelchair modified for leg propulsion using voluntary activity or electrical stimulation.

Medical Engineering & Physics 25(1): 11-19

Davoodi et al. (2002)*

Development of an indoor rowing machine with manual FES controller for total body exercise in paraplegia.

IEEE Transactions on Neural Systems & Rehabilitation Engineering 10(3): 197-203

Gates et al. (2002)*

Absence of training-specific cardiac adaptation in paraplegic athletes.

Medicine & Science in Sports & Exercise 34(11): 1699-1704

Gerasimenko et al. (2002)

Control of locomotor activity in humans and animals in the absence of supraspinal influences.

Neuroscience & Behavioral Physiology 32(4): 417-423

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Jones et al. (2002)*

Intensive exercise may preserve bone mass of the upper limbs in spinal cord injured males but does not retard demineralisation of the lower body.

Spinal Cord 40(5): 230-235

Kilkens et al. (2002)*

The wheelchair circuit: Reliability of a test to assess mobility in persons with spinal cord injuries.

Archives of Physical Medicine and Rehabilitation 83(12): 1783-1788

Knikou et al. (2002)*

Hip angle induced modulation of H reflex amplitude, latency and duration in spinal cord injured humans.

Clinical Neurophysiology 113(11): 1698-1708

Mirbagheri et al. (2002)*

The effects of long-term FES-assisted walking on intrinsic and reflex dynamic stiffness in spastic spinal-cord-injured subjects.

IEEE Transactions on Neural Systems & Rehabilitation Engineering 10(4): 280-289

Reft et al. (2002)

Trajectories of target reaching arm movements in individuals with spinal cord injury: Effect of external trunk support.

Spinal Cord 40(4): 186-191

Cooper et al. (2001)

Evaluation of a pushrim-activated, power-assisted wheelchair.

Archives of Physical Medicine and Rehabilitation 82(5): 702-708

Cooper et al. (2001)*

Physiological responses to two wheelchair-racing exercise protocols.

Neurorehabilitation & Neural Repair 15(3): 191-195

Field-Fote (2001)*

Combined use of body weight support, functional electric stimulation, and treadmill training to improve walking ability in individuals with chronic incomplete spinal cord injury.

Archives of Physical Medicine and Rehabilitation 82(6): 818-824

Gerrits et al. (2001)*

Peripheral vascular changes after electrically stimulated cycle training in people with spinal cord injury.

Archives of Physical Medicine and Rehabilitation 82(6): 832-839

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Gharooni et al. (2001)

A new hybrid spring brake orthosis for controlling hip and knee flexion in the swing phase.

IEEE Transactions on Neural Systems & Rehabilitation Engineering 9(1): 106-107

Mohr et al. (2001)*

Insulin action and long-term electrically induced training in individuals with spinal cord injuries.

Medicine & Science in Sports & Exercise 33(8): 1247-1252

Protas et al. (2001)

Supported treadmill ambulation training after spinal cord injury: A pilot study.

Archives of Physical Medicine and Rehabilitation 82(6): 825-831

Rodgers et al. (2001)

Influence of training on biomechanics of wheelchair propulsion.

Journal of Rehabilitation Research & Development 38(5): 505-511

Seelen et al. (2001)*

Motor preparation in postural control in seated spinal cord injured people.

Ergonomics 44(4): 457-472

Brissot et al. (2000)*

Clinical experience with functional electrical stimulation-assisted gait with Parastep in spinal cord-injured patients.

Spine 25(4): 501-508

Ditunno et al. (2000)*

Walking index for spinal cord injury (WISCI): An international multicenter validity and reliability study.

Spinal Cord 38(4): 234-243

Gerrits et al. (2000)*

Altered contractile properties of the quadriceps muscle in people with spinal cord injury following functional electrical stimulated cycle training.

Spinal Cord 38(4): 214-223

Harvey et al. (2000)

A randomized trial assessing the effects of 4 weeks of daily stretching on ankle mobility in patients with spinal cord injuries.

Archives of Physical Medicine and Rehabilitation 81(10): 1340-1347

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Petrofsky et al. (2000)*

The relationship between exercise work intervals and duration of exercise on lower extremity training induced by electrical stimulation in humans with spinal cord injuries.

European Journal of Applied Physiology 82(5-6): 504-509

Rodgers et al. (2000)

Influence of trunk flexion on biomechanics of wheelchair propulsion.

Journal of Rehabilitation Research & Development 37(3): 283-295

Beekman et al. (1999)

Energy cost of propulsion in standard and ultralight wheelchairs in people with spinal cord injuries.

Physical Therapy 79(2): 146-158

Chilibeck et al. (1999)*

Histochemical changes in muscle of individuals with spinal cord injury following functional electrical stimulated exercise training.

Spinal Cord 37(4): 264-268

Curtis et al. (1999)*

Effect of a standard exercise protocol on shoulder pain in long-term wheelchair users.

Spinal Cord 37(6): 421-429

Houtman et al. (1999)

Effect of a pulsating anti-gravity suit on peak exercise performance in individual with spinal cord injuries.

European Journal of Applied Physiology & Occupational Physiology 79(2): 202-204

Kamper et al. (1999)

Preliminary investigation of the lateral postural stability of spinal cord-injured individuals subjected to dynamic perturbations.

Spinal Cord 37(1): 40-46

Kjaer et al. (1999)*

Heart rate during exercise with leg vascular occlusion in spinal cord-injured humans.

Journal of Applied Physiology 86(3): 806-811

Lajoie et al. (1999)

Attentional requirements of walking in spinal cord injured patients compared to normal subjects.

Spinal Cord 37(4): 245-250

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Middleton et al. (1999)*

Postural control during stance in paraplegia: Effects of medially linked versus unlinked knee-ankle-foot orthoses.

Archives of Physical Medicine and Rehabilitation 80(12): 1558-1565

Newsam et al. (1999)

Three-dimensional upper extremity motion during manual wheelchair propulsion in men with different levels of spinal cord injury.

Gait & Posture 10(3): 223-232.

Sarver et al. (1999)

A study of shoulder motions as a control source for adolescents with C4 level SCI.

IEEE Transactions on Rehabilitation Engineering 7(1): 27-34

Hopman et al. (1998)*

Blood redistribution and circulatory responses to submaximal arm exercise in persons with spinal cord injury.

Scandinavian Journal of Rehabilitation Medicine 30(3): 167-174

Klokker et al. (1998)*

The natural killer cell response to exercise in spinal cord injured individuals.

European Journal of Applied Physiology & Occupational Physiology 79(1): 106-109

Lamontagne et al. (1998)*

Evaluation of reflex- and nonreflex-induced muscle resistance to stretch in adults with spinal cord injury using hand-held and isokinetic dynamometry.

Physical Therapy 78(9): 964-975

Norman et al. (1998)

Effects of drugs on walking after spinal cord injury.

Spinal Cord 36(10): 699-715

Schmid et al. (1998)

Catecholamines, heart rate, and oxygen uptake during exercise in persons with spinal cord injury.

Journal of Applied Physiology 85(2): 635-641

Schmid et al. (1998)*

Physical performance and cardiovascular and metabolic adaptation of elite female wheelchair basketball players in wheelchair ergometry and in competition.

American Journal of Physical Medicine & Rehabilitation 77(6): 527-533

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Segal et al. (1998)

4-Aminopyridine alters gait characteristics and enhances locomotion in spinal cord injured humans.

Journal of Spinal Cord Medicine 21(3): 200-204

Silva et al. (1998)*

Effect of aerobic training on ventilatory muscle endurance of spinal cord injured men.

Spinal Cord 36(4): 240-245

Functional Electrical Stimulation and Functional Magnetic Stimulation

Capel et al. (2003)

The amelioration of the suffering associated with spinal cord injury with subperception transcranial electrical stimulation.

Spinal Cord 41(2): 109-117

Eser et al. (2003)*

Influence of different stimulation frequencies on power output and fatigue during FES-cycling in recently injured SCI people.

IEEE Transactions on Neural Systems & Rehabilitation Engineering 11(3): 236-240

Goldfarb et al. (2003)*

Preliminary evaluation of a controlled-brake orthosis for FES-aided gait.

IEEE Transactions on Neural Systems & Rehabilitation Engineering 11(3): 241-248

Stein et al. (2003)*

A wheelchair modified for leg propulsion using voluntary activity or electrical stimulation.

Medical Engineering & Physics 25(1): 11-19

Birch et al. (2002)

Initial on-line evaluations of the LF-ASD brain-computer interface with able-bodied and spinal-cord subjects using imagined voluntary motor potentials.

IEEE Transactions on Neural Systems & Rehabilitation Engineering 10(4): 219-222

Craig et al. (2002)

The effectiveness of a hands-free environmental control system for the profoundly disabled.

Archives of Physical Medicine and Rehabilitation 83(10): 1455-1458

Davoodi et al. (2002)*

Development of an indoor rowing machine with manual FES controller for total body exercise in paraplegia.

IEEE Transactions on Neural Systems & Rehabilitation Engineering 10(3): 197-203

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Ioannides et al. (2002)

Brain activation sequences following electrical limb stimulation of normal and paraplegic subjects.

Neuroimage 16(1): 115-129

Lin et al. (2002)

Functional magnetic stimulation facilitates gastric emptying.

Archives of Physical Medicine and Rehabilitation 83(6): 806-810

Mirbagheri et al. (2002)*

The effects of long-term FES-assisted walking on intrinsic and reflex dynamic stiffness in spastic spinal-cord-injured subjects.

IEEE Transactions on Neural Systems & Rehabilitation Engineering 10(4): 280-289

Rodic et al. (2002)*

Magnetic stimulation of sacral roots for assessing the efferent neuronal pathways of lower urinary tract.

Muscle & Nerve 26(4): 486-491

Taylor et al. (2002)

The functional impact of the Freehand System on tetraplegic hand function. Clinical results.

Spinal Cord 40(11): 560-566

Field-Fote (2001)*

Combined use of body weight support, functional electric stimulation, and treadmill training to improve walking ability in individuals with chronic incomplete spinal cord injury.

Archives of Physical Medicine and Rehabilitation 82(6): 818-824

Mela et al. (2001)

Excessive reflexes in spinal cord injury triggered by electrical stimulation.

Archives of Physiology & Biochemistry 109(4): 309-315

Misawa et al. (2001)*

The effects of therapeutic electric stimulation on acute muscle atrophy in rats after spinal cord injury.

Archives of Physical Medicine and Rehabilitation 82(11): 1596-1603

Mohr et al. (2001)*

Insulin action and long-term electrically induced training in individuals with spinal cord injuries.

Medicine & Science in Sports & Exercise 33(8): 1247-1252

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Petrofsky (2001)*

The use of electromyogram biofeedback to reduce Trendelenburg gait.

European Journal of Applied Physiology 85(5): 491-495

Brissot et al. (2000)*

Clinical experience with functional electrical stimulation-assisted gait with Parastep in spinal cord-injured patients.

Spine 25(4): 501-508

Crameri et al. (2000)

Effects of electrical stimulation leg training during the acute phase of spinal cord injury: A pilot study.

European Journal of Applied Physiology 83(4-5): 409-415

Gerrits et al. (2000)*

Altered contractile properties of the quadriceps muscle in people with spinal cord injury following functional electrical stimulated cycle training.

Spinal Cord 38(4): 214-223

Petrofsky et al. (2000)*

The relationship between exercise work intervals and duration of exercise on lower extremity training induced by electrical stimulation in humans with spinal cord injuries.

European Journal of Applied Physiology 82(5-6): 504-509

Riess et al. (2000)

Adaptive neural network control of cyclic movements using functional neuromuscular stimulation.

IEEE Transactions on Rehabilitation Engineering 8(1): 42-52

Sampson et al. (2000)

Functional electrical stimulation effect on orthostatic hypotension after spinal cord injury.

Archives of Physical Medicine and Rehabilitation 81(2): 139-143

van Beekvelt et al. (2000)

The effect of electrical stimulation on leg muscle pump activity in spinal cord-injured and able-bodied individuals.

European Journal of Applied Physiology 82(5-6): 510-516

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Borgens et al. (1999)

An imposed oscillating electrical field improves the recovery of function in neurologically complete paraplegic dogs.

Journal of Neurotrauma 16(7): 639-657

Chilibeck et al. (1999)*

Histochemical changes in muscle of individuals with spinal cord injury following functional electrical stimulated exercise training.

Spinal Cord 37(4): 264-268

Hillegass et al. (1999)*

Surface electrical stimulation of skeletal muscle after spinal cord injury.

Spinal Cord 37(4): 251-257

Murphy et al. (1999)

Salbutamol effect in spinal cord injured individuals undergoing functional electrical stimulation training.

Archives of Physical Medicine and Rehabilitation 80(10): 1264-1267

Baldi et al. (1998)*

Muscle atrophy is prevented in patients with acute spinal cord injury using functional electrical stimulation.

Spinal Cord 36(7): 463-469

Byers et al. (1998)*

An electromechanical testing device for assessment of hand motor function.

IEEE Transactions on Rehabilitation Engineering 6(1): 88-94

Lin et al. (1998)*

Functional magnetic stimulation for restoring cough in patients with tetraplegia.

Archives of Physical Medicine and Rehabilitation 79(5): 517-522

Lin et al. (1998)*

Effects of an abdominal binder and electrical stimulation on cough in patients with spinal cord injury.

Journal of the Formosan Medical Association 97(4): 292-295

Imaging

Epstein et al. (2003)*

Documenting fusion following anterior cervical surgery: A comparison of roentgenogram versus two-dimensional computed tomographic findings.

Journal of Spinal Disorders & Techniques 16(3): 243-247

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Tsuji et al. (2001)*

Evaluation of spinal cord blood flow during prostaglandin E1-induced hypotension with power Doppler ultrasonography.

Spinal Cord 39(1): 31-36

Liu et al. (2000)*

Quantitative computed tomography in the evaluation of spinal osteoporosis following spinal cord injury.

Osteoporosis International 11(10): 889-896

Brugieres et al. (1999)*

Dynamic MRI in the evaluation of syringomyelic cysts.

Neuro-Chirurgie 45(Suppl 1): 115-129

Selden et al. (1999)*

Emergency magnetic resonance imaging of cervical spinal cord injuries: Clinical correlation and prognosis.

Neurosurgery 44(4): 785-792

Shepard et al. (1999)*

Magnetic resonance imaging and neurological recovery in acute spinal cord injury: Observations from the National Acute Spinal Cord Injury Study 3.

Spinal Cord 37(12): 833-837

Splavski et al. (1998)

Computed tomography of the spine as an important diagnostic tool in the management of war missile spinal trauma.

Archives of Orthopaedic & Trauma Surgery 117(6-7): 360-363

Immunology

Edwards et al. (2001)

Modified cotton gauze dressings that selectively absorb neutrophil elastase activity in solution.

Wound Repair & Regeneration 9(1): 50-58

Ersoz et al. (1999)

Platelet aggregation in traumatic spinal cord injury.

Spinal Cord 37(9): 644-647

Klokker et al. (1998)*

The natural killer cell response to exercise in spinal cord injured individuals.

European Journal of Applied Physiology & Occupational Physiology 79(1): 106-109

Waites et al. (1998)

Immunogenicity of pneumococcal vaccine in persons with spinal cord injury.

Archives of Physical Medicine and Rehabilitation 79(12): 1504-1509

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Mental Health, Behavior, and Patient Well-Being

Hicks et al. (2003)*

Long-term exercise training in persons with spinal cord injury: Effects on strength, arm ergometry performance and psychological well-being.

Spinal Cord 41(1): 34-43

Kennedy et al. (2003)

Coping effectiveness training reduces depression and anxiety following traumatic spinal cord injuries.

British Journal of Clinical Psychology 42(Pt 1): 41-52

Alexander et al. (2002)

Mothers with spinal cord injuries: Impact on marital, family, and children’s adjustment.

Archives of Physical Medicine and Rehabilitation 83(1): 24-30

Phillips et al. (2001)

Telehealth: Reaching out to newly injured spinal cord patients.

Public Health Reports 116(Suppl 1): 94-102

Unalan et al. (2001)

Quality of life of primary caregivers of spinal cord injury survivors living in the community: Controlled study with short form-36 questionnaire.

Spinal Cord 39(6): 318-322

Hultling et al. (2000)*

Quality of life in patients with spinal cord injury receiving Viagra (sildenafil citrate) for the treatment of erectile dysfunction.

Spinal Cord 38(6): 363-370

Kreuter et al. (1998)

Partner relationships, functioning, mood and global quality of life in persons with spinal cord injury and traumatic brain injury.

Spinal Cord 36(4): 252-261

Potter et al. (1998)*

Randomized double-blind crossover trial of Fampridine-SR (sustained release 4-aminopyridine) in patients with incomplete spinal cord injury.

Journal of Neurotrauma 15(10): 837-849

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Radnitz et al. (1998)

A comparison of post-traumatic stress disorder in veterans with and without spinal cord injury.

Journal of Abnormal Psychology 107(4): 676-680

Muscle and Spasticity

Gagnon et al. (2003)*

Biomechanical analysis of a posterior transfer maneuver on a level surface in individuals with high and low-level spinal cord injuries.

Clinical Biomechanics 18(4): 319-331

Gregory et al. (2003)

Effects of testosterone replacement therapy on skeletal muscle after spinal cord injury.

Spinal Cord 41(1): 23-28

Grijalva et al. (2003)

Efficacy and safety of 4-aminopyridine in patients with long-term spinal cord injury: A randomized, double-blind, placebo-controlled trial.

Pharmacotherapy 23(7): 823-834

Hayes et al. (2003)

Pharmacokinetics of an immediate-release oral formulation of Fampridine (4-aminopyridine) in normal subjects and patients with spinal cord injury.

Journal of Clinical Pharmacology 43(4): 379-385

Hicks et al. (2003)*

Long-term exercise training in persons with spinal cord injury: effects on strength, arm ergometry performance and psychological well-being.

Spinal Cord 41(1): 34-43

Faghri et al. (2002)

Electrically induced and voluntary activation of physiologic muscle pump: A comparison between spinal cord-injured and able-bodied individuals.

Clinical Rehabilitation 16(8): 878-885

Godfrey et al. (2002)*

Differential fatigue of paralyzed thenar muscles by stimuli of different intensities.

Muscle & Nerve 26(1): 122-131

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Hidler et al. (2002)

Frequency response characteristics of ankle plantar flexors in humans following spinal cord injury: Relation to degree of spasticity.

Annals of Biomedical Engineering 30(7): 969-981

Jacobs et al. (2002)

Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury.

Archives of Physical Medicine and Rehabilitation 83(1): 19-23

Kakebeeke et al. (2002)

The importance of posture on the isokinetic assessment of spasticity.

Spinal Cord 40(5): 236-243

Raynor et al. (2002)

Can triggered electromyograph thresholds predict safe thoracic pedicle screw placement?

Spine 27(18): 2030-2035

Thomas et al. (2002)

Motor unit activation order during electrically evoked contractions of paralyzed or partially paralyzed muscles.

Muscle & Nerve 25(6): 797-804

Burns et al. (2001)

Intrathecal baclofen in tetraplegia of spinal origin: Efficacy for upper extremity hypertonia.

Spinal Cord 39(8): 413-419

Misawa et al. (2001)*

The effects of therapeutic electric stimulation on acute muscle atrophy in rats after spinal cord injury.

Archives of Physical Medicine and Rehabilitation 82(11): 1596-1603

Petrofsky (2001)*

The use of electromyogram biofeedback to reduce Trendelenburg gait.

European Journal of Applied Physiology 85(5): 491-495

Seelen et al. (2001)*

Motor preparation in postural control in seated spinal cord injured people.

Ergonomics 44(4): 457-472

van der Bruggen et al. (2001)

Randomized trial of 4-aminopyridine in patients with chronic incomplete spinal cord injury.

Journal of Neurology 248(8): 665-671

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Wolfe et al. (2001)

Effects of 4-aminopyridine on motor evoked potentials in patients with spinal cord injury: A double-blinded, placebo-controlled crossover trial.

Journal of Neurotrauma 18(8): 757-771

Castro et al. (2000)

Muscle fiber type-specific myofibrillar Ca2+ ATPase activity after spinal cord injury.

Muscle & Nerve 23(1): 119-121

Donovan et al. (2000)*

Intravenous infusion of 4-AP in chronic spinal cord injured subjects.

Spinal Cord 38(1): 7-15

Elokda et al. (2000)

Effect of functional neuromuscular stimulation on postural related orthostatic stress in individuals with acute spinal cord injury.

Journal of Rehabilitation Research & Development 37(5): 535-542

Gerrits et al. (2000)*

Altered contractile properties of the quadriceps muscle in people with spinal cord injury following functional electrical stimulated cycle training.

Spinal Cord 38(4): 214-223

Halter et al. (2000)

Intrathecal administration of 4-aminopyridine in chronic spinal injured patients.

Spinal Cord 38(12): 728-732

Hiersemenzel et al. (2000)*

From spinal shock to spasticity: Neuronal adaptations to a spinal cord injury.

Neurology 54(8): 1574-1582

Segal et al. (2000)

Absorption characteristics of sustained-release 4-aminopyridine (Fampridine SR) in patients with chronic spinal cord injury.

Journal of Clinical Pharmacology 40(4): 402-409

Sherwood et al. (2000)

Altered motor control and spasticity after spinal cord injury: Subjective and objective assessment.

Journal of Rehabilitation Research & Development 37(1): 41-52

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Akman et al. (1999)

Assessment of spasticity using isokinetic dynamometry in patients with spinal cord injury.

Spinal Cord 37(9): 638-643

Castro et al. (1999)

Influence of complete spinal cord injury on skeletal muscle cross-sectional area within the first 6 months of injury.

European Journal of Applied Physiology & Occupational Physiology 80(4): 373-378

Castro et al. (1999)

Influence of complete spinal cord injury on skeletal muscle within 6 mo of injury.

Journal of Applied Physiology 86(1): 350-358

Chilibeck et al. (1999)*

Histochemical changes in muscle of individuals with spinal cord injury following functional electrical stimulated exercise training.

Spinal Cord 37(4): 264-268

Dudley et al. (1999)

A simple means of increasing muscle size after spinal cord injury: A pilot study.

European Journal of Applied Physiology & Occupational Physiology 80(4): 394-396

Gaviria et al. (1999)*

Variability of the fatigue response of paralyzed skeletal muscle in relation to the time after spinal cord injury: Mechanical and electrophysiological characteristics.

European Journal of Applied Physiology & Occupational Physiology 80(2): 145-153

Hillegass et al. (1999)*

Surface electrical stimulation of skeletal muscle after spinal cord injury.

Spinal Cord 37(4): 251-257

Potten et al. (1999)

Postural muscle responses in the spinal cord injured persons during forward reaching.

Ergonomics 42(9): 1200-1215

Segal et al. (1999)

Safety and efficacy of 4-aminopyridine in humans with spinal cord injury: A long-term, controlled trial.

Pharmacotherapy 19(6): 713-723

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Baldi et al. (1998)*

Muscle atrophy is prevented in patients with acute spinal cord injury using functional electrical stimulation.

Spinal Cord 36(7): 463-469

Bracken et al. (1998)*

Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial.

Journal of Neurosurgery 89(5): 699-706

Dalyan et al. (1998)

Factors associated with contractures in acute spinal cord injury.

Spinal Cord 36(6): 405-408

Geisler (1998)

Clinical trials of pharmacotherapy for spinal cord injury.

Annals of the New York Academy of Sciences 845:374-381

Konishi et al. (1998)

Electrophysiologic evaluation of denervated muscles in incomplete paraplegia using macro electromyography.

Archives of Physical Medicine and Rehabilitation 79(9): 1062-1068

Lamontagne et al. (1998)*

Evaluation of reflex- and nonreflex-induced muscle resistance to stretch in adults with spinal cord injury using hand-held and isokinetic dynamometry.

Physical Therapy 78(9): 964-975

Noreau et al. (1998)

Comparison of three methods to assess muscular strength in individuals with spinal cord injury.

Spinal Cord 36(10): 716-723

Potter et al. (1998)*

Randomized double-blind crossover trial of Fampridine-SR (sustained release 4-aminopyridine) in patients with incomplete spinal cord injury.

Journal of Neurotrauma 15(10): 837-849

Seelen et al. (1998)

Development of new muscle synergies in postural control in spinal cord injured subjects.

Journal of Electromyography & Kinesiology 8(1): 23-34

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Seelen et al. (1998)

Postural motor programming in paraplegic patients during rehabilitation.

Ergonomics 41(3): 302-316

Neurological Responses

Horlocker et al. (2003)

Small risk of serious neurologic complications related to lumbar epidural catheter placement in anesthetized patients.

Anesthesia & Analgesia 96(6): 1547-1552

Cariga et al. (2002)

Segmental recording of cortical motor evoked potentials from thoracic paravertebral myotomes in complete spinal cord injury.

Spine 27(13): 1438-1443

Knikou et al. (2002)*

Hip angle induced modulation of H reflex amplitude, latency and duration in spinal cord injured humans.

Clinical Neurophysiology 113(11): 1698-1708

Collins et al. (2001)

Large involuntary forces consistent with plateau-like behavior of human motoneurons.

Journal of Neuroscience 21(11): 4059-4065

Legramante et al. (2001)*

Positive and negative feedback mechanisms in the neural regulation of cardiovascular function in healthy and spinal cord-injured humans.

Circulation 103(9): 1250-1255

Hiersemenzel et al. (2000)*

From spinal shock to spasticity: Neuronal adaptations to a spinal cord injury.

Neurology 54(8): 1574-1582

Houtman et al. (2000)

Sympathetic nervous system activity and cardiovascular homeostatis during head-up tilt in patients with spinal cord injuries.

Clinical Autonomic Research 10(4): 207-212

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Tran et al. (2000)

Increased threshold sural amplitude after upper limb isometric contraction in complete paraplegics.

American Journal of Physical Medicine & Rehabilitation 79(6): 542-546

Lacourse et al. (1999)

Cortical potentials during imagined movements in individuals with chronic spinal cord injuries.

Behavioural Brain Research 104(1-2): 73-88

Baba et al. (1998)

Cervical myeloradiculopathy with entrapment neuropathy: A study based on the double-crush concept.

Spinal Cord 36(6): 399-404

Levander et al. (1998)

Are there any mild interhemispheric effects after moderately severe closed head injury?

Brain Injury 12(2): 165-173

Maurer et al. (1998)

Usefulness and diagnostic value of evoked potentials in patients with neurologic diseases in postoperative intensive care.

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie 33(7): 430-440

Vaidyanathan et al. (1998)*

Pathophysiology of autonomic dysreflexia: Long-term treatment with terazosin in adult and paediatric spinal cord injury patients manifesting recurrent dysreflexic episodes.

Spinal Cord 36(11): 761-770

Outcome Measures and Health Assessment

Gillette et al. (2002)

Center of pressure measures to assess standing performance.

Biomedical Sciences Instrumentation 38:239-244

Ishida et al. (2002)

Predictors of neurologic recovery in acute central cervical cord injury with only upper extremity impairment.

Spine 27(15): 1652-1658

Kilkens et al. (2002)*

The wheelchair circuit: Reliability of a test to assess mobility in persons with spinal cord injuries.

Archives of Physical Medicine and Rehabilitation 83(12): 1783-1788

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Tobimatsu et al. (2001)

The order of re-acquirement of activity of daily living functions in people with spinal cord injury during rehabilitation after initial medical treatment and its affecting factors.

Tohoku Journal of Experimental Medicine 194(3): 181-190

Ditunno et al. (2000)*

Walking index for spinal cord injury (WISCI): An international multicenter validity and reliability study.

Spinal Cord 38(4): 234-243

Taricco et al. (2000)

Functional status in patients with spinal cord injury: A new standardized measurement scale. Gruppo Interdisciplinare Valutazione Interventi Riabilitativi.

Archives of Physical Medicine and Rehabilitation 81(9): 1173-1180

Craig et al. (1999)

Improving the long-term adjustment of spinal cord injured persons.

Spinal Cord 37(5): 345-350

Mulcahey et al. (1999)

Evaluation of the lower motor neuron integrity of upper extremity muscles in high level spinal cord injury.

Spinal Cord 37(8): 585-591

Vaccaro et al. (1999)

Magnetic resonance evaluation of the intervertebral disc, spinal ligaments, and spinal cord before and after closed traction reduction of cervical spine dislocations.

Spine 24(12): 1210-1217

Byers et al. (1998)*

An electromechanical testing device for assessment of hand motor function.

IEEE Transactions on Rehabilitation Engineering 6(1): 88-94

Cheliout-Heraut et al. (1998)

Evaluation of early motor and sensory evoked potentials in cervical spinal cord injury.

Neurophysiologie Clinique 28(1): 39-55

Claxton et al. (1998)*

Predictors of hospital mortality and mechanical ventilation in patients with cervical spinal cord injury.

Canadian Journal of Anaesthesia 45(2): 144-149

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Pruitt et al. (1998)*

Health behavior in persons with spinal cord injury: Development and initial validation of an outcome measure.

Spinal Cord 36(10): 724-731

Toh et al. (1998)

Functional evaluation using motor scores after cervical spinal cord injuries.

Spinal Cord 36(7): 491-496

Pain

Ahn et al. (2003)

Gabapentin effect on neuropathic pain compared among patients with spinal cord injury and different durations of symptoms.

Spine 28(4): 341-346

Finnerup et al. (2003)

Sensory function above lesion level in spinal cord injury patients with and without pain.

Somatosensory & Motor Research 20(1): 71-76

Malinovsky et al. (2003)

Sedation caused by clonidine in patients with spinal cord injury.

British Journal of Anaesthesia 90(6): 742-745

Cardenas et al. (2002)

Efficacy of amitriptyline for relief of pain in spinal cord injury: Results of a randomized controlled trial.

Pain 96(3): 365-373

Finnerup et al. (2002)

Lamotrigine in spinal cord injury pain: A randomized controlled trial.

Pain 96(3): 375-383

Kuesgen et al. (2002)

Decreased cutaneous sensory axon-reflex vasodilatation below the lesion in patients with complete spinal cord injury.

Somatosensory & Motor Research 19(2): 149-152

Tai et al. (2002)

Gabapentin in the treatment of neuropathic pain after spinal cord injury: A prospective, randomized, double-blind, crossover trial.

Journal of Spinal Cord Medicine 25(2): 100-105

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Turner et al. (2002)

Blinding effectiveness and association of pretreatment expectations with pain improvement in a double-blind randomized controlled trial.

Pain 99(1-2): 91-99

Defrin et al. (2001)

Characterization of chronic pain and somatosensory function in spinal cord injury subjects.

Pain 89(2-3): 253-263

Dyson-Hudson et al. (2001)*

Acupuncture and Trager psychophysical integration in the treatment of wheelchair user’s shoulder pain in individuals with spinal cord injury.

Archives of Physical Medicine and Rehabilitation 82(8): 1038-1046

Sindou et al. (2001)*

Microsurgical DREZotomy for pain due to spinal cord and/or cauda equina injuries: Long-term results in a series of 44 patients.

Pain 92(1-2): 159-171

Attal et al. (2000)

Intravenous lidocaine in central pain: A double-blind, placebo-controlled, psychophysical study.

Neurology 54(3): 564-574

Averill et al. (2000)*

Blood pressure response to acupuncture in a population at risk for autonomic dysreflexia.

Archives of Physical Medicine and Rehabilitation 81(11): 1494-1497

Donovan et al. (2000)*

Intravenous infusion of 4-AP in chronic spinal cord injured subjects.

Spinal Cord 38(1): 7-15

Siddall et al. (2000)

The efficacy of intrathecal morphine and clonidine in the treatment of pain after spinal cord injury.

Anesthesia & Analgesia 91(6): 1493-1498

Curtis et al. (1999)*

Effect of a standard exercise protocol on shoulder pain in long-term wheelchair users.

Spinal Cord 37(6): 421-429

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Saddiki-Traki et al. (1999)

Differences between the tactile sensitivity on the anterior torso of normal individuals and those having suffered complete transection of the spinal cord.

Somatosensory & Motor Research 16(4): 391-401

Demirel et al. (1998)

Pain following spinal cord injury.

Spinal Cord 36(1): 25-28

Vaidyanathan et al. (1998)*

Pathophysiology of autonomic dysreflexia: Long-term treatment with terazosin in adult and paediatric spinal cord injury patients manifesting recurrent dysreflexic episodes.

Spinal Cord 36(11): 761-770

Physiological Responses

Jacobs et al. (2003)

Physiologic responses to electrically assisted and frame-supported standing in persons with paraplegia.

Journal of Spinal Cord Medicine 26(4): 384-389

Spungen et al. (2003)

Factors influencing body composition in persons with spinal cord injury: A cross-sectional study.

Journal of Applied Physiology 95(6): 2398-2407

Cooper et al. (2001)*

Physiological responses to two wheelchair-racing exercise protocols.

Neurorehabilitation & Neural Repair 15(3): 191-195

Apstein et al. (1998)

Serum lipids during the first year following acute spinal cord injury.

Metabolism: Clinical & Experimental 47(4): 367-370

Bauman et al. (1998)

The effect of residual neurological deficit on serum lipoproteins in individuals with chronic spinal cord injury.

Spinal Cord 36(1): 13-17

Klefbeck et al. (1998)

Obstructive sleep apneas in relation to severity of cervical spinal cord injury.

Spinal Cord 36(9): 621-628

Schmid et al. (1998)

Free plasma catecholamines in spinal cord injured persons with different injury levels at rest and during exercise.

Journal of the Autonomic Nervous System 68(1-2): 96-100

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Respiration

Koga et al. (2001)

Comparison of no airway device, the Guedel-type airway and the cuffed oropharyngeal airway with mask ventilation during manual in-line stabilization.

Journal of Clinical Anesthesia 13(1): 6-10

Liaw et al. (2000)

Resistive inspiratory muscle training: Its effectiveness in patients with acute complete cervical cord injury.

Archives of Physical Medicine and Rehabilitation 81(6): 752-756

Singas et al. (1999)

Inhibition of airway hyperreactivity by oxybutynin chloride in subjects with cervical spinal cord injury.

Spinal Cord 37(4): 279-283

Claxton et al. (1998)*

Predictors of hospital mortality and mechanical ventilation in patients with cervical spinal cord injury.

Canadian Journal of Anaesthesia 45(2): 144-149

Estenne et al. (1998)

Effects of abdominal strapping on forced expiration in tetraplegic patients.

American Journal of Respiratory & Critical Care Medicine 157(1): 95-98

Fein et al. (1998)

The effects of ipratropium bromide on histamine-induced bronchoconstriction in subjects with cervical spinal cord injury.

Journal of Asthma 35(1): 49-55

Silva et al. (1998)*

Effect of aerobic training on ventilatory muscle endurance of spinal cord injured men.

Spinal Cord 36(4): 240-245

Tromans et al. (1998)

The use of the BiPAP biphasic positive airway pressure system in acute spinal cord injury.

Spinal Cord 36(7): 481-484

Sexual Function

Dalmose et al. (2003)

Conditional stimulation of the dorsal penile/clitoral nerve may increase cystometric capacity in patients with spinal cord injury.

Neurourology & Urodynamics 22(2): 130-137

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Ethans et al. (2003)*

The effects of sildenafil on the cardiovascular response in men with spinal cord injury at or above the sixth thoracic level.

Journal of Spinal Cord Medicine 26(3): 222-226

Laessoe et al. (2003)*

Effects of ejaculation by penile vibratory stimulation on bladder capacity in men with spinal cord lesions.

Journal of Urology 169(6): 2216-2219

Schmid et al. (2003)*

Clinical value of combined electrophysiological and urodynamic recordings to assess sexual disorders in spinal cord injured men.

Neurourology & Urodynamics 22(4): 314-321

Brackett et al. (2002)

Semen retrieval in men with spinal cord injury is improved by interrupting current delivery during electroejaculation.

Journal of Urology 167(1): 201-203

Mirbagheri et al. (2002)*

The effects of long-term FES-assisted walking on intrinsic and reflex dynamic stiffness in spastic spinal-cord-injured subjects.

IEEE Transactions on Neural Systems & Rehabilitation Engineering 10(4): 280-289

Trabulsi et al. (2002)

Leukocyte subtypes in electroejaculates of spinal cord injured men.

Archives of Physical Medicine and Rehabilitation 83(1): 31-34

Lebib Ben Achour et al. (2001)

Intracavernous injections in the treatment of erectile dysfunction in spinal cord injured patients: Experience with 36 patients.

Annales de Readaptation et de Medecine Physique 44(1): 35-40

Sanchez et al. (2001)

Efficacy, safety and predictive factors of therapeutic success with sildenafil for erectile dysfunction in patients with different spinal cord injuries.

Spinal Cord 39(12): 637-643

Hultling et al. (2000)*

Quality of life in patients with spinal cord injury receiving Viagra (sildenafil citrate) for the treatment of erectile dysfunction.

Spinal Cord 38(6): 363-370

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Mallidis et al. (2000)

Necrospermia and chronic spinal cord injury.

Fertility & Sterility 74(2): 221-227

Schmid et al. (2000)

Sildenafil in the treatment of sexual dysfunction in spinal cord-injured male patients.

European Urology 38(2): 184-193

Sipski et al. (2000)*

Sildenafil effects on sexual and cardiovascular responses in women with spinal cord injury.

Urology 55(6): 812-815

Bodner et al. (1999)

Intraurethral alprostadil for treatment of erectile dysfunction in patients with spinal cord injury.

Urology 53(1): 199-202

Giuliano et al. (1999)

Randomized trial of sildenafil for the treatment of erectile dysfunction in spinal cord injury. Sildenafil Study Group.

Annals of Neurology 46(1): 15-21

Giuliano et al. (1999)

Sildenafil citrate (Viagra): A novel oral treatment for erectile dysfunction caused by traumatic spinal cord injury.

International Journal of Clinical Practice Supplement 102:24-26

Hultling (1999)

Partners’ perceptions of the efficacy of sildenafil citrate (Viagra) in the treatment of erectile dysfunction.

International Journal of Clinical Practice Supplement 102:16-18

Jackson et al. (1999)

A multicenter study of women’s self-reported reproductive health after spinal cord injury.

Archives of Physical Medicine and Rehabilitation 80(11): 1420-1428

Maytom et al. (1999)

A two-part pilot study of sildenafil (Viagra) in men with erectile dysfunction caused by spinal cord injury.

Spinal Cord 37(2): 110-116

Brackett et al. (1998)

An analysis of 653 trials of penile vibratory stimulation in men with spinal cord injury.

Journal of Urology 159(6): 1931-1934

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Courtois et al. (1998)

Sympathetic skin responses and psychogenic erections in spinal cord injured men.

Spinal Cord 36(2): 125-131

Derry et al. (1998)

Efficacy and safety of oral sildenafil (Viagra) in men with erectile dysfunction caused by spinal cord injury.

Neurology 51(6): 1629-1633

Le Chapelain et al. (1998)

Ejaculatory stimulation, quality of semen and reproductive aspects in spinal cord injured men.

Spinal Cord 36(2): 132-136

Surgery

Brodke et al. (2003)

Comparison of anterior and posterior approaches in cervical spinal cord injuries.

Journal of Spinal Disorders & Techniques 16(3): 229-235

Epstein et al. (2003)*

Documenting fusion following anterior cervical surgery: A comparison of roentgenogram versus two-dimensional computed tomographic findings.

Journal of Spinal Disorders & Techniques 16(3): 243-247

Papadopoulos et al. (2002)

Immediate spinal cord decompression for cervical spinal cord injury: Feasibility and outcome.

Journal of Trauma: Injury Infection & Critical Care 52(2): 323-332

Sustic et al. (2002)

Surgical tracheostomy versus percutaneous dilational tracheostomy in patients with anterior cervical spine fixation: Preliminary report.

Spine 27(17): 1942-1945

Sindou et al. (2001)*

Microsurgical DREZotomy for pain due to spinal cord and/or cauda equina injuries: Long-term results in a series of 44 patients.

Pain 92(1-2): 159-171

Tator et al. (1999)

Current use and timing of spinal surgery for management of acute spinal cord injury in North America: Results of a retrospective multicenter study.

Journal of Neurosurgery 91(1 Suppl): 12-18

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Syringomyelia

Wirth et al. (2001)

Feasibility and safety of neural tissue transplantation in patients with syringomyelia.

Journal of Neurotrauma 18(9): 911-929

Brugieres et al. (1999)*

Dynamic MRI in the evaluation of syringomyelic cysts.

Neuro-Chirurgie 45(Suppl 1): 115-129

Hort-Legrand et al. (1999)

Evoked motor and sensory potentials in syringomyelia.

Neuro-Chirurgie 45(Suppl 1): 95-104

Perrouin-Verbe et al. (1999)

Post-traumatic syringomyelia.

Neuro-Chirurgie 45(Suppl 1): 58-66

Perrouin-Verbe et al. (1998)

Post-traumatic syringomyelia and posttraumatic spinal canal stenosis: A direct relationship: Review of 75 patients with a spinal cord injury.

Spinal Cord 36(2): 137-143

Ulcers and Pressure Sores

Sprigle et al. (2003)

Relationships among cushion type, backrest height, seated posture, and reach of wheelchair users with spinal cord injury.

Journal of Spinal Cord Medicine 26(3): 236-243

Han et al. (2002)

The value of Jamshidi core needle bone biopsy in predicting postoperative osteomyelitis in grade IV pressure ulcer patients.

Plastic & Reconstructive Surgery 110(1): 118-122

Adegoke et al. (2001)

Acceleration of pressure ulcer healing in spinal cord injured patients using interrupted direct current.

African Journal of Medicine & Medical Sciences 30(3): 195-197

Brienza et al. (1999)

A method for custom-contoured cushion design using interface pressure measurements.

IEEE Transactions on Rehabilitation Engineering 7(1): 99-108

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×

Topic and Author(s)

Study Title

Journal Reference

Krause (1998)

Skin sores after spinal cord injury: Relationship to life adjustment.

Spinal Cord 36(1): 51-56

Ljungberg (1998)

Comparison of dextranomer paste and saline dressings for management of decubital ulcers.

Clinical Therapeutics 20(4): 737-743

Suggested Citation:"Appendix G Spinal Cord Injury Clinical Trials Published from 1998 to 2003." Institute of Medicine. 2005. Spinal Cord Injury: Progress, Promise, and Priorities. Washington, DC: The National Academies Press. doi: 10.17226/11253.
×
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Next: Appendix H Legislation Sponsoring State Spinal Cord Injury Research »
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An estimated 11,000 spinal cord injuries occur each year in the United States and more than 200,000 Americans suffer from maladies associated with spinal cord injury. This includes paralysis, bowel and bladder dysfunction, sexual dysfunction, respiratory impairment, temperature regulation problems, and chronic pain. During the last two decades, longstanding beliefs about the inability of the adult central nervous system to heal itself have been eroded by the flood of new information from research in the neurosciences and related fields. However, there are still no cures and the challenge of restoring function in the wake of spinal cord injuries remains extremely complex.

Spinal Cord Injury examines the future directions for research with the goal to accelerate the development of cures for spinal cord injuries. While many of the recommendations are framed within the context of the specific needs articulated by the New York Spinal Cord Injury Research Board, the Institute of Medicine’s panel of experts looked very broadly at research priorities relating to future directions for the field in general and make recommendations to strengthen and coordinate the existing infrastructure. Funders at federal and state agencies, academic organizations, pharmaceutical and device companies, and non-profit organizations will all find this book to be an essential resource as they examine their opportunities.

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