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Spinal Cord Injury: Progress, Promise, and Priorities
Assessment
biomarker applications, 77–79
of complications of spinal cord injury, 76
experimental models, 65
of functional outcomes of spinal cord injury, 74–76
imaging technologies, 83–88
injury classification, 32–36
injury outcomes, 260–267
pain, 53
recommendations for research, 89
research needs, 8 , 10
standardization of outcome measures, 168–172 , 178–179
technical development, 64
Astrocytes, 37
in glial scarring, 43
Atrophy, muscle, 112
Autonomic dysreflexia, 105
Autonomic nervous system
motor function and, 48
research goals, 2 , 24
Axon anatomy and function, 31
embryonic development, 130
spinal cord pathophysiology, 43
Axonal regrowth, 3
animal models, 65–66 , 70 , 71–73
barriers to, strategies to remove, 127–129
cell transplantation to promote, 132 , 135–136
combination therapies to promote, 140–141
environmental conditions for, 45–46 , 129
gene therapies to improve, 130–132
glial scarring in inhibition of, 43–45 , 127
guidance, 129–130
in vitro studies, 65
macrophage therapy to improve, 123
molecular processes, 65
muscle spasticity and, 52
neurotrophic factors to promote, 135
pain outcomes and, 101–102
research needs, 58
research recommendations, 4 , 8 , 143
restoration of impulse conduction, 133–134
spontaneous healing, 47
strategies for promoting, 129
synaptic connections, 129
tissue scaffolding to promote, 132
Axon anatomy and function, 31
embryonic development, 130
spinal cord pathophysiology, 43
B
Baclofen, 102
Basal ganglia, 48
Basso, Beattie, and Bresnahan (BBB) scale, 74–76 , 260
Basso Mouse Scale (BMS), 74–76 , 260–261
Bathing abilities, 17 , 19
Bed mobility, 16 , 18
Biomarkers, 8 , 89
applications, 77–79
current technology, 77
future prospects for research, 81–83
in imaging technologies, 85–87
Bladder function, 105
anatomy, 55
outcomes by level of injury, 16 , 18
pathophysiology, 55–56 , 103
research goals, 2 , 24
therapeutic interventions, 103–104 , 110–111
types of dysfunction, 103
Blood pressure, spinal cord injury and, 39
Body weight support training, 108–110
Bone disorders, 107
Bowel function, 104 , 105
outcomes by level of injury, 16 , 18
pathophysiology, 56–57
research goals, 2 , 24
Brain-derived neurotrophic factor, 126
Brain stem, motor function, 48
Bryon Reisch Paralysis Foundation, 191
Buoniconti Fund to Cure Paralysis, 191
C
C fibers, 56
Calcium, intracellular, 126
in apoptosis, 42–43
in spinal cord injury pathophysiology, 41
California, 213 , 223–227
Reeve-Irvine Research Center, 6 , 155 , 224
stem cell bill, Proposition 71 , 226–227