FIGURE 2-1 Formation of the multiple peripheral blood cells from multipotent hematopoietic stem cells.

SOURCE: Guyton and Hall, 2000.

a broad range of disorders for which transplantion of HPCs from an adult donor is also successful, including hematological malignancies, solid tumors, constitutional and acquired bone marrow failure syndromes, hemoglobinopathies, congenital immune deficiencies, and inherited disorders of metabolism (Gluckman et al., 1997; Locatelli et al., 1999; Rocha et al., 2000; Locatelli et al., 2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. Since then cord blood banking programs throughout the world have expanded rapidly (Broxmeyer, 1998), with the estimated number of units stored to date exceeding 155,000 (BMDW, 2004).

The establishment of at least three independent, international registries of outcome data—the International Cord Blood Transplant Registry (ICBTR) in 1992 (which was transferred to the International Bone Marrow Transplant Registry [IBMTR] in 1996, and to the Center for International



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