Level 1 laboratories are designed for low-risk work; level 4 laboratories can handle organisms that pose the most serious risks. Laboratories at each classification level must meet different design criteria and conform to different operating procedures. The University of Georgia AHRC building will house level 2 and 3 laboratories.

Biosafety level 1 (BSL-1)

is used for working with agents having no known or minimal hazard to laboratory personnel and the environment; the organisms are unlikely to cause illness in people or animals.

• Work is generally conducted on open bench tops with standard microbiological practices.

• Examples: Bacillus subtilis, nonpathogenic E. coli

Biosafety level 2 (BSL-2)

is suitable for work involving agents of moderate potential hazard to personnel and the environment. Should a person become infected, treatment is available, and the risk of spreading the infection to others is low.

• Any laboratory procedure with these agents that may create an aerosol must be done within a biological safety cabinet.

• Examples: Salmonella spp., Shigella spp., most animal viruses

Biosafety level 3 (BSL-3)

is applicable to work done with agents that may cause serious illness to people or animals but cannot spread easily to others; treatment is available.

All procedures involving the manipulation of infectious materials must be done within biological safety cabinets or other appropriate containment devices. The laboratory has special engineering and design features including separation from traffic flow, water-resistant surfaces for cleaning, sealed windows, and ducted exhaust air ventilation.

• Examples: virulent Newcastle disease virus, HIV research level, Coxiella burnettii (Q fever), E. coli 0157:H7

Bioterror:

A form of terrorism that employs the use of biological and chemical weapons.

Bovine tuberculosis:

Tuberculosis in cattle caused by infection with the bacterium Mycobacterium bovis, which can be transmitted to other animals and to humans.

Brucellosis:

A disease of domestic animals, such as cattle, sheep, goats, and dogs, that is caused by brucellae and sometimes results in spontaneous abortions in newly infected animals. In humans it is caused by any of



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