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~~ ~~ ~ ^~1 ~~ ~1 ~ Guide for the Care and Use of Laboratory Animals

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~~ ~~ ^~1 ~~ ~1 ~ Guide for the Care and Use of Laboratory Animals by institute of Laboratory Animal Resources Commission on Life Sciences National Research Council, USA National Academy Press Washington D.C. 1996 7~T: it A] ~ (~ C~) KAP J. LEE (Professor and Director Division of Comparative Medicine University Of North Dakota. USA) 037.~: 7~7eT (~ef~+ ~70) ~~ (~ In - AN ~ol~) ol Cozy (~l*rH8~i;l ~l;21 Aft ~~f~AL~) ~A|T (A= am) Hi li!i rim 1998

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,, ~ D ~ ~4 ^~1 ~~ 1 Committee to Revise the Guide for the Care and Use of Laboratory Animals J. Derrell Clark(Chairman), University of Georgia, College of Veterinary Medicine, Athens, Georgia Ransom L. Baldwin, University of California. Davis. California KathrYn A. Bayne, American Association for Accreditation of Laboratory Animal Care. Rockville, Maryland Marilyn J. Brown, Dartmouth College. Lebanon, New Hampshire G. F. Gebhart, University of lowa. College of Medicine, Iowa City, Iowa Janet C. Gonder. Baxter Healthcare Corporation, Round Lake. Illinois Judith K. Gwathmey, Harvard Medical School. Massachusetts Michale E. Keeling. University of Texas M.D. Anderson Cancer Center, Bastrop, Texas Dennis F. Kohn. Columbia University, College of Physicians & Surgeons. New York, New York J. Wesley Robb, Professor Emeritus. University of Southern California. Los Angeles, California Orville A Smith, University of Washington, Seattle. Washington Jo Ann D.Steggerda. Champaign, Illinois John G. Vandenbergh. North Carolina State University, Raleigh, North Carolina William J. White, Charles River Laboratories, Wilmington, Massachusetts Sarah Williams-Blangero, Southwest Foundation for Biomedical Research. San Antonio. Texas John L. VandeBerg, Southwest Foundation for Biomedical Research, San Antonio, Texas (ex officio member) Thomas L.Wolfoe. Program Director Carol M.Rozmiarek, Project Assistant Norman Grossblatt, Editor 7

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Rag ~~.1l Fir Ed If ~~ INSTITUTE OF LABORATORY ANIMAL RESOURCES COUNCIL John L. VandeBerg (Chairman). Southwest Foundation for Biomedical Research, San Antonio. Texas Christian R. Abee, University of South Alabama, Mobile, Alabama J. Derrell Clark. University of Georgia, College of Veterinary Medicine, Athens, Georgia Muriel T. Davisson, The Jackson Laboratory. Bar Harbor, Maine Bennett Dyke, Southwest Foundation for Biomedical Research, San Antonio. Texas Neal L, First, University of Wisconsin, Madison, Wisconsin James W. Glosser, Massillon, Ohio John P. Hearn, Wisconsin Regional Primate Research Center. Madison Margaret S. Landi, Smith Kline Beecham Pharmaceuticals, King of Prussia, Pennsylvania Gail Martin. University of California, San Francisco, California Charles R. McCarthy, Kennedy Institute of Ethics. Georgetown University. Washington, D. C. Robert J. Russell. Harlan Sprague Dawley, Frederick. Maryland Richard C. Van Sluyters, University of California, Berkeley, California John G. Vandebergh, North Carolina State University. Raleigh. North Carolina Peter A. Ward. University of Michigan Medical School, Ann Arbor, Michigan Thomas D. Pollard, The Johns Hopkins University School of Medicine, Baltimore. Maryland (ex officio member) :~m Eric A Fischer, Director Thomas L. Wolfle, Program Director Mara L, Glenshaw. Research Assistant Carol M. Rozmiarek, Project Assistant A.1Y~!~I(lnstitute of Laboratory Animal Resources: ALAR) ~~~+ ~~1q~ I ~~ l952~l I. ~anO~4 ~~ ol~ O ~A1 ~+ AI ~ ~~ a -4~ ~ ~ 4 ' 1 In, =~ ~ At~q ~~ ~1 ~ ~ that ~ my DISH I, =eJ ~~ol~ to ~~ ~ Whole Hit ~~ ~ ~~ ~ of T. Baby ~4 07 ~ 01~ Al off ~ Okay ~~840~7~1$nl~ Atn5 ~ ~~, 8

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DO Eq e ~IV84~ $1~1 Comrnission on Life Sciences Thomas D.Pollard (Chairman).The Johns Hopkins University School of Medicine, Baltimore. Maryland Frederick R. Anderson. Cadwalader. Wickersham & Taft, Washington, D.C. John C. Bailar. III, IvlcCil University. Montreal, Canada John E, Burris, Marine Biological Laboratory, Woods Hole, Massachusetts Michael T. Coegg. University of California. Riverside, California Glenn A. Crosby, Washington State University, Pullman. Washington Ursula W. Goodenough. Washington University, St. Louis. Missouri Susan E. Leeman. Boston University School of Medicine, Boston. Massachusetts Richard E. Lenski. Michigan State University, East Lansing. Michigan Thomas E. Lovejoy, Smithsonian Institution, Washington. D.C. Donald R. Mattison. University of Pittsburgh, Pittsburgh, PennsYIvania Joseph E. Murray. WellesleY Hills, Massachusetts Edward E. Penhoet, Chiron Corporation. Emeryville, California Emil A. Pfitzer, Research institute for Fragrance Materials, inc.. Hackensack, New Jersey Malcolm C. Pike, University of Southern California School of Medicine. Los Angeles. California Henry C. Pitot, III. McArdle Laboratory for Cancer Research. Madison, Wisconsin Jonathan M. Samet, The Johns Hopkins University. Baltimore, Maryland Harold M. Schmeck, Jr., North Chatham, Massachusetts Carla H. Shatz, University of California, Berkeley, California John L. VandeBerg, Southwest Foundation for Biomedical Research, San Antonio, Texas 7.~i: Paul Gilman. Executive Director 9

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