Cover Image

Not for Sale



View/Hide Left Panel
Click for next page ( 9


The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement



Below are the first 10 and last 10 pages of uncorrected machine-read text (when available) of this chapter, followed by the top 30 algorithmically extracted key phrases from the chapter as a whole.
Intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text on the opening pages of each chapter. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

Do not use for reproduction, copying, pasting, or reading; exclusively for search engines.

OCR for page 8
~ - ~ Institutional Policies and Responsibilities Ffi~ ~~ ~~ ~~=~ ~ lkW~34!~;~ ~'J14~ . It 1~1~.~ ~ *~Ffi~ ~~-~ Ll~ ~~!~ I ~~S~17/~,~ ~ Dd;Z.7~;~1 Mini tli~it~ ~ ~7\'i:~ j~t~*~;~rq~;~ ~11~ AWRs (CFR 1985) ~ PHS policy (PUS 1996) ~ ]~Rt~ *, ~~ ~ ~~,~z~y~ (IACUC) Yl~'~li-~3~z~ ~77~ ~ ~~~~.~ =?F~-~:~)~2t ~-- ~~ I ~ - 1~!~)~ ~ ~;1~h~Ffi~l~l~b~lZl i~-3~3~ ~~ ~~h~i~-~-~ ~ ~~Zk MONITORING THE CARE AND USE OF ANIMALS ~5-~b~t~ Institutional Animal Care and Use Committee ~i|~;K0;~i3~|~ i~;~55~5~$~/~ Zen ~~ (lACUC) ~ '1~3~ ~~ MAKE) $i:1~; the AWRs ~ PHS ~y~3~ a ;~ g~yy3~ p`11'~ ~i~lf~1~ ~ ~1~;141~ 311~ ~ ~~r3~Hel ~:llii~^l~q~I~y~h ~i tamp ~5~1~1; t~l~i~1~(-n=~3~7ls~y~$t B)~ t~l~3,ll~ ~ ~i~3~5 ~~! ,K,l O ~~-~~~ 35~ ~5~1 ~ _~jjI~ ~ Y1~5-'t~ 8

OCR for page 8
/~=~;~i~o,~;~~!~ Hi. By;; I' ~ l ~G~.~ PHS ~~ AM ~~ In. ~ = 'it i~i~fib~ ~ ~~ ~ ~~ ~'1~l)$l1~;l~1~^ ~ TV ~~ 6 ~ 3~-~-~ HI ~ ~.~g:$~b~7Ji~;1l~ $~.~:i~~hl~ ~6 'I'~ o ~~ ~ ~.~Ep IACUC ~~.~ ('~1 Avers, PHS policy (IRAC 1955; see Appendix D) ~ and this Guide (see footnote, p.2)) ~$~3~ Animal Care and Use Protocols ~;~G/E~i~ $/i~$t}~ 3~{~ ~ ~ l~y44 b!~9F~;~ my. ~ ~38'~.~$~Z3~fi53~Ek ~ ~J#~=~ ~ It 1~!~.~=-t~ I ~~ ~l~z~1~: flybill ~~~ ~~l~Llil] fe ? ~~ft7~'1~f~ (see Appendix A, "Alternatives) ? ~~=at$!l~;~ me ;~O . I. ~~: (see Appendix A, "Anesthesia, Pain and surgery) ~ ~~r~1~7~i~ ~~I+J)li~!~It ~ ~$~ ~ ~~b`ei~ me ~ ; ~,~;~:~0 ~3$~y6~i~o I: 9

OCR for page 8
~-~fr~ ~~I~L]~ ~~ ~~ 3~1~ ~~.~hu;l~l]~ ~~f) )~f~; 'IN: ~7~q; ~~5~yE~ ,, ~~33~1~El~L~, me ,0\~, Wit ~ tE In . ~~ rid I L~E-~I~h,~ ~~ ~~ 3, ~ OF j1~7,~l ' licit/~Z~i~E-CAM ' t1~LE~ )~ ~ ~~ , Last - ~ T *e ~.~~1~11~ ~~O Physical Restraint FfiE~i~lE'~1~f~;!Ql~J~l~bT'L%13~*~iK~] Jo ' ~~ ' ~~ ' ~;~;~-= ~ 7 ~,~ ~~,h,$~;.7E ~ EM~~x ~!~l~lJ~I~h,$~h~; I ~ Ffi~f~ :'' i-==t ~~ ~~h.~Ffi~ L ~l~i~:~ ~ ~~ ~ ~~ (e.g., Reinhardt Ig91, 1995) ~ ~~y,h ~1~!~41~hqLl~1|~ . ~~E4~-a~ E) ~,~,F1~q~j~, )~lE~?j~7,j~;~ ~ . ~~ ' ~ Ad ~ O ~ ~~,F?7~j~ ~~Ffi-CEl~fJ~l ~D[!~I~ ' ~~ j~l]~ ''I ~~ ~ ~!~7~,Lla) ~E~iE~;~IIt~L]I)I~ itt~c~ ~~ ~ ~~eeffl~ (Bryant TWO; Byrd 1979; Grandin Igg]; McNanee and others 19R4; Marion and others 19R7; Wakeley and others 1974) o ~j:Ei~F,3 I.; ~~:~[~7r~;~!~!~tl~]ilL7t~ ~ jil~Ji~>S~e~l]~:it7c hk~:~bO Err.; ;~ ~ iE~i~.cl~v~L9]lh CALM o |>07jlJ~)3,,3~i.~E~~it: l~it;~,i~3~XA'~3q~^ ~l<~f~13~ ~~] to ~ ~~ ~/~I~ o 10

OCR for page 8
~E~=r~ ~ gut ~~w ~~ ~ /~] ' media ~ ~~ Q HI ~!~ 1~ ~~ ' HI]J~;A~ ~}~ ~ MA 1~1 art; 717~;~ ~ICI~ f~11~7X~ $j!5 i;~!3 I' - 7~:# STOW Multiple Major Surgical Pro ~JtAe1~ ;~2!~;;~3~ ~~y~!~1 = ~ HEM~~ ~~i~7<~LJ;~ - Ad ~ Old - ~=n,~...~:iZ~ ~/j/~ ISLAM IACUC ~1~ i~3~ 3 '35~7~,~J~i~5ifi id, ~~.'Li~ . ~~/~m ~~ ]~ ~ ~~ o~,~14~ e~.~tl7i~ 76~1~'~7~7~7~ ~~ ~7k~] Food or Fluid Restriction ~~ ~~ ~ ~~,t~7kiti~$~ ~~.~ ~~t~ 7kL1~]'~t~ ~~ ~~ filmy ~'~11~h~1~ 1A Let ~~!bt#~.7x~ ( Ok 1~ ~ ) ~~ I: It 61 ~ ~~ E] ~;~ ~ ~~tt~50~)~;~ - tt ~Y''~ if 23!l!U~7I ~~ JI:~;~$lFS4~ 3; J1A~A36~;~ ~ 7k my ,. tip ~~ ~ ~~ ~ 7k7~t~'~~ (NIH ~1~ 4~ ~ ~h$~ ~ ~:~t;~hO O ~~ ~ tam t~9 A1&~ ~ ~[,t~;~:~q~; ~$~8 (NYAS 1988) li~l~ ~~gt~ ~~q~l~ ~~ }mat (lath) ~!!~ ~ ~J$IJ!idlilb~l~lE$~1 ~ ~~IE~121 o ~=~q~_~A~IJ 11

OCR for page 8
~3~ VETERINARY CARE ~~ Lo ~~LF~ ~~ ~ ~~ ~l~71< ~ L test ~ ~~._~_ If ~~ ~ ~~9~T ~ ~~ pr=9 . FIJI - ~ti':~f~ If ~~Q~4b$~'~jL~ ;~FL6$~(~ A) ~)~ . ~~ AWRS ~ PHS ~~=t~; ~ _~!~;~s~ . ~~ . ~J]:~: ~ Aims ~j] N~z~311~ PERSONNEL QUALIFICATIONS AND TRAINING AWRs 1~. PHS ~~l~h~ ilY.)Lt~0 ~ ~~.~ ~1~ ~~ ,. ~~> q ;~;~.iLi~, ~~ . ~~ {fi~h~3 ~~ ~~o ~:~h~'~ll~ JO A ~ "Technicalar,d Professional Education", ~t3~J1ll~) ~ ~1~;~E~i~]E~. ~-~;tEI~II~ ~ ~lhU~h~L-t~ '~7~3~] ' ~~.L=-t~l4~ll~ ' I I ~.~h~ ~ ~~ ~ ' I o :~i~74~11~ ~ ~5'1~-~7 7h~j~l,~=~ (AVMA 1995) ~ 1i,~it~q~!~i~ ' ~;~EI~:~ ~ tE.~;~:~$h~7~Hld ~L~!~6h~V~(AALAS)~.g~.7~ ~tbl~!~ limbo (my B) 3 hIJ~ff~h~l~/~ ~~)~J~l~.>l:~tn~I ~~L Ah ~~.~h~ 12

OCR for page 8
~~ ~ ~~II~If75~If$~~~ ~ ~~ ~~,.If~ (Kreger 1995) ~ ~,=,3EP~II~1 :~Llf~~~ ~ CCAC Gift ~~ Ala ~ | ~~u fit #~ (AWIC) ILAR (NRC 1991) (CCAC 1993), (Appendix B) 2 ~l~aL~ '~ ' ~11~ 'AL ' . Am. .fi~ Elf emu ~.~I~JIl~Iffl=~tl~ ~~ ~1~ t - Low ~ If ~ )~, ., . AL 'C He _ OCCUPATIONAL HEALTH AND SAFETY OF PERSONNEL 4~l~,~;> r-lt~ ~~ few 2~i~i~ at ;~a|~(CDC and NIH 1993; CFR 1984a, b, c, PHS policy) o tr~t~l~.~ ~ Ji~l~Il~lk ;S~lI;Fffi9i1~ o Ma iE'~,L7~1~ ~1F,5Al4~~1 HI f/~3 jail, Of~ 1~3~ AL Z>~;T~11~ YE NRC ~:~I~ ~ Ft]cPf~ ~ /Oil ~ ~fi~tilDlD5~~=Dt~l~q~:~:~ item =~41~: ~F~;~==t~q(~3fFF3~3'~.~0 ~b~;~ ~~f~J~-==t~l 3 f~~$~ ~s~~g ~3~3~ ~j~Ift~fib9:~f~lkE3 E3 Of~~f:3~;~L, ~ p~;1 L111;~ >Rit~fi~;~.~ ~f~)J~q~ ~ Of L ~fif~f*~l~b $41~!~f6;~l~ ~ i~$tlik~t .1,~i~f6:~ f~q~n!lib~l~f~ ~~f~i~i~$21~ ~~f~5~3~ ~E.~In Ill,-,'- ~~i~ ~~$ 1; I f~Fi~-~f~fY~lif~ Of' =~fir,~a,~<~,~ .~,43~3i14~3~ .~!~,11~fii~afr4?~ F~'[~LE~$: 5; JE$~iE=f'L30~P~f~ 13

OCR for page 8

OCR for page 8
It ~~ ' ~~~1J~DC1~ a~I ~ AD; ~ At ~$~ ~~=~==t~ ~ ~F~$b~.~L =~=at~l~ ~ Clf - `J~ig~ ~ ID ~f~=~7~.~Clf~ ~~ ~~il~.~:~:~;~;@~(5~= PELs)~ ~ p14~,~ Iambi - ~~ . IL~,~,~(CFR 1 Fib) ~ fob Anitnal Experunentation involving Hazards BEAM= ~ Cl~fi~;~z~ ~ art >I4~;~7l;~:~ ~~q~;~J~ ' 34~D~)~ I75~Z~r3~17~;~7( ~71~27~;~13a~ ~~$JZ<.~b$~ G~;;?~Q~Z~IJ'= )l~l~ili35~ $1=11 ~~;~ik ~,~ ~3 11 ~~ ~~ +;~ ~;~-----~~1] 0 ~il~ ~ fig 14 3~ Afar ~$~1 ~ ~ ~~ ~$~1~ ~ ~~;I]~iliffi~ E!ga$c~ ~~At ( kD~ ) . ~ ED ~~f6;l~'d~I~ ~ ~~ ~1~:7~,~ ~13~= ~l~il~=~)~Cl~.~,~tlq ~-~tAD~ ~ I. Cl~a=-it:D~ me, ~~=~ Clefts ~~b9~l~, ~ta=fi~I?K~k ~ ~~Cl;~ll~3~, cam ~36~=a^Cl]~05~1~!~ ~;1~1 ~111~3~ Cleft . Deftdam: ~ ~b~i~tlDZ;c~s~r4~ (CDC)~ NIH [13~ Biosafety to Microbioigical and Biomedical Laboratones ( 1993) o ~ NRC b~l~l2innr4~;~ i~f6;~ ~arl.1~ CDC ;I;~,I~fi~;~; E: ~D: ~l11~t~;~1!3~ ~ Apt 17=a~r4;?l~ ~ ~b~fFJ!8!~ ~ ~~-a~l=~t~ ~ Cl~!~r4 bj~ ~ ~~$~3~f~nDn ~ ig~b~0FD~ 15

OCR for page 8
~I~ ~ ~~ ~~ ~ ~~. ~Jlk~7r; ~ ~~t0QiZ~i ~ #~ ~ I ~.~.=$~ ~ ~1] It ~~~;i~=t~7i~ ~ ~~g~i~ ~1] ~ ~',r,~10~ ~ ~~-~'~ it ~7~7k~i~7k~ ~7k~ ~~7km f~$~aa~7,~I~ ~ ~ ~ ~~i,~:l~ 1~ I' hi;? 3~ Cl d~;?lDiini5~il~ o ~7 ~:tJf6;F~!~ ~ ~Ppl~l~!~ ~(CDC 1995; Kruse and others 1991) ~ '~t~--~i ~ L1~ ~~'~ ~ I, Let, I. ~ i; ~~:k~ ~ ~~Kd~lJl=~r~ i~'~-~I ~1~3~ ~ 2iL~:~I]~ i~ ~ ~ ~ ,f ~ ~~ ~~ Phi ~ I. r~=~?-~ ~ f~FD~Z~ I ;, h ~=~ ~ L1~I~ ~Nr~ Personal Protection ~ J<~I;~,iLt~ ~~ ~ ~~, ~~ ~ ~ At, ~~,iLi ~ ~~ ~ ~ h ~ ~ l ~ ~ ~ h ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ PLY ' ~l ' ~~ ~i~t~I~ l~ ~'l~i~ ~ f~'l~i7~ ~ I~f~ft~I~ fig ~~pLz~7~aI~ ~f~f~ `Il;zfi~;l~l~I~ ~ E~.~it~fitL aaZ1= ,'lLl'~ 'a fi(CFR 1984c) ~ Add ,=~i~.~h~=I ~~n ~ ~i*~ ~ ~~ my; 0 r~ ~ I; ~ lo*= 0 ff~'~ ~q~/*~ j(CFR 1984c) 0 16

OCR for page 8

OCR for page 8
REFERENCES AVMA (Amencan Veterinary Medical Association). 1995. Accredited programs in veterinary tech- nology. Pp. 236-240 in 1995 AVMA Membership Directory and Resource Manual, 44th ed. Schaumburg, 111.: AVMA. Bryamt, J. M. 1980. Vest and tethering system to accommodate catheters and a temperature monitor for nonhuman primates. Lab. Anim. Sci. 30(4 Part 1):706-708 Byrd, L. D. 1979. A tethering system for direct measurement of cardiovascular function in the caged baboon. Am. J. Physiol. 236:H775-H779. CCAC (Canadian Council on Animal Care) 1993. Guide to the Care and Use of Experimental Animals, Vol. 1, 2nd ed. E. D. Olfert, B. M. Cross, and A. A. McWilliam, eds. Ontario, Canada: Canadian Council on Animal Care. 211 pp. CDC (Centers for Disease Control and Prevention and NIH (National Institutes of Health). 1993. Biosafety in Microbiological and Biomedical Laboratories. 3rd ed. HHS Publication No. (CDC) 93-8395, Washington, D.C.: U.S. Government Printing Office. CDC (Centers for Disease Control and Prevention) and NIH (National Institutes of Health). 1995. Primary Containment for Biohazards: Selection, Lqstallation and Use of Biological Safety Cabi- nets. Washington, D.C.: U.S. Govemment Printing Of fice. CFR (Code of Federal Regulations). 1984a. Title 10; Part 20, Standards for Protection Against Radiation. Washington, D.C.: Office of the Federal Register CFR (Code of Federal Regulations). 1984b. Title 29; Part 1910, Occupational Safety and Health Standards; Subpart G. Occupation Health and Environmental Control, and Subpart Z. Toxic and Hazardous Substances. Washington, D.C.: Of fice of the Federal Register. CFR (Code of Federal Regulations). 1984c. Title 29; Part 1910, Occupational Safety and Health Standards; Subpart 1, Personal Protective Equipment. Washington, D.C.: Of fice of the Federal Register. CFR (Code of Federal Regulations). 1985. Title 9 (Animals and Animal Products), Subchapter A (Animal Welfare). Washington, D.C.: Of fice of the Federal Register. Clark, J. M. 1993. Planning for safety: biological and chemical hazards. Lab Anim. 22:33-38. Fox, J. G., C. E. Newcomer, and H. Rozmiarek. 1984. Selected zoonoses and other health hazards. Pp. 614-648 in Laboratory Animal Medicine, J. G. Fox, B. J. Cohen, and F. M. Loew, eds. New York: Academic Press. Grandin, T. 1991. Livestock behavior and the design of livestock handling facilities. Pp. 96-125 in Handbook of Facilities Planning. Vol. 2. Laboratory Animal Facilities. New York: Van Nostrand. 422 pp. Holmes, G. P., L. E. Chapman, J. A. Stewart, S. E. Straus, J. K. Hilliard, D. S. Davenport, and the B Virus Working Group. 1995. Guidelines for the prevention and treatment of B-virus infections in exposed persons. Clin. infect. Dis. 20:421-439. IRAC (Interagency Research Animal Committee). 1985. U.S. Govemment Principles for Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training. Federal Register, May 20, 1985. Washington, D.C.: Of flee of Science and Technology Policy. Kreger, M. D., 1995. Training Matenals for Animal Facility Personnel: AWIC Quick Bibliography Senes, 95-08. Beltsville, Md.: National Agricultural Library. Kruse, R. H., W. H. Puckett, and J. H. Richardson. 1991. Biological safety cabinetry. Clin. Micro. Reviews 4:207-241. McNamee, G. A., Jr., R. W. Wannemacher, Jr., R. E. Dintemman, H. Rozmiarek, and R. D. Montrey. 1984. A surgical procedure and tethering system for chronic blood sampling, infusion, and temperature monitonng in caged nonhuman primates, Lab. Anim. Sci. 34(3):303-307. Morton, W. R., G. H. Knitter, P. M. Smith, T. G. Susor, and K. Schmitt. 1987. Altematives to chronic restraint of nonhuman pnmates. J. Am. Vet. Med. Assoc. 191(10):1282-1286. 18

OCR for page 8
NIH (National institutes of Health). 1990. Guidelines for Diet Control in Behavioral Study. Bethesda. Md.: Animal Research Advisory Committee, NIH. NRC (National Research Council). 1990. Important laboratory animal resources: selection criteria and funding mechanisms for their preservation. A report of the Institute of Laboratory Anima Resources Committee on Preservation of Laboratory Animal Resources. ILAR News 32(4):AI- A32. NRC (National Research Council). 1991. Education and Training in the Care and Use of Laboratory Animals: A Guide for Developing institutional Programs. A report of the institute of Labora- tory Animal Resources Committee on Educational Programs in Laboratory Animal Science. Washington, D C: National Academy Press. 152 pp. NRC (National Research Council). in press. Occupational Health and Safety in the Care and Use of Research Animals. A report of the institute of Laboratory Animal Resources Committee on Occuparional Safety and Health in Research Ammal Facilities. Washington, D.C.: National Academy Press. NYAS (New York Academy of Sciences). 1988. Interdisciplinary Principles and Guidelines for the Use of Animals in Research, Testing and Education. New York: New York Academy of Sci- ences. PHS (Public Health Service). 1996. Public Health Service Policy on Humane Care and Use of Laboratory Animals. Washington, D.C.: U.S. Depa tment of Hea th and Human Services, 28 pp. [PL 99-158, Health Research Extension Act, 1985] Reinhardt, V. 1991. Training adult male rhesus monkeys to actively cooperate during in-homecage venupuncture. Anim. Technol. 42(1):11-17. Reinhardt, V. 1995. Restraint methods of laboratory non-human primates: a cnucal review. Anim. Weif. 4:221-238. Van Sluyters, R. C., and M. D. Oberdorfer, eds. 1991. Preparation and Maintenance of Higher Mammals During Neuroscience Expenments. Report of N. aloha institute of Health Workshop NIH No. 91-3207. Bethesda, Md.: National institutes of Health. Wakeley, H., J. Dudek, and J. Kruckeberg. 1974. A method for preparing and maintaining rhesus monkeys with chronic venous catheters. Behav. Res. Methods Instrum. 6:329-331. 19