Cover Image

PAPERBACK
$30.00



View/Hide Left Panel
Click for next page ( R2


The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement



Below are the first 10 and last 10 pages of uncorrected machine-read text (when available) of this chapter, followed by the top 30 algorithmically extracted key phrases from the chapter as a whole.
Intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text on the opening pages of each chapter. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

Do not use for reproduction, copying, pasting, or reading; exclusively for search engines.

OCR for page R1
lgg6~(~ ~ i) ,~q~6)~ ~ ~m ~ ~] _= =~_ Jo ~ /If; 7~-~(l$)9 OCR for page R1
National Academy Press 2101 Constitution Avenue, NW, Washingon, DC 20418, USA Aim Waft ~ in . ~ jeq*~7 v ~ ~ ~ ~ It, [d Of- ,- T . h w'$National Acaden y of Sciences, [341 iLI:~J ~ ~ $National Academy of Engineering~'tt lf'l~ii&~lllstihlte of Medicinec7)t =tNfi61:F~I.t ~ ~A.'ih~J i 7a, 1341 ;r.1dF'~t~'~fi~National Research Councilo~;ft=R,r.~ A, ~ ~1 t~hkhO:gthqhL ~ fi tt~<7 ~ 7. ~ 77i 1, ?National Center for Research ResourcesO)'~tl4~tiblt1~Nllw~r Interagency Research Animal Committeel;~tZJtif~f#l ~FqTlL'}i'Department of Health and Human Services~l~ ffi*rff 31:FfrNational Institutes of Healthl: 4t7~lll~f~lS~>J~Office for Protection from Research Risks: AklUf4.nTh~U S. Department of Agriculture; I-Y r 7 Department of Veterans Afairs, of ', ~ 13?it3~;ttjl$;~.7o)Itip[~7 D 7 7 L IP is, NIH RR08779 020 ~ftJ~l?j~i~tLt_, rl~L`f 7tM=7it. 1t?tit1~ffiitfi,~lnstituteofl.aboratoryAnimalResourcesl:lit ~ L t *, (hi-)t~-/,~'t)J tx1J-t~lub~'cN~sit~oidi~)l*: :l~lL~'l-ilf5':ifi ff t fff+~'A tb1JE jg67'=774. 5P40RR0137: itj~lt tNational Science Foundation, BIR 9024967: ~ il ? j ~ 'pi' ~ ~ [IF ~ 3g ~ j1~ f j IJ . S Army Medical Research and Development CommandOJIY9 ~ &~(IFll~iY'fJDepartmenL of Defence, ~i~l~trlii2 r L lilted tU S Air Force System CommandO t ~7 ~ i 2 r L Kohl Human System Division. Lfilt t~t~R~L~bff~ fiArmed Forces Radiobiology Research Institute, d R tN!i~X~Uniformed Services University of Health Sciencest'~t i '~iTIi{~ ?I\-~ iffy '1 join 7i~3U S Naval Medical Research and Development Command. DAMD17 93 J 3016: 7i~1~b.it2~A:llerican Cancer Society A ff477 D i ~ ~ 'A to a, ARC 1 34, *I f ~ I .. - .F~i Amp, pi J: the id ~ L 1' l l t~o)~:l *, fife i i ?.'4i i . tH ii ?; iii IhLit~'i UJL.1 , 1~;1~1-, t JO ~ ittli.o A, Ji?i* ~ v~ 1 Rift* *I. iklilLC(Kf * ~ ~1 t ~ aJft4o)Ti ft*3~1~t# *A it ~ ~ Itit IL`Z~bitl~64~. ISBN U 309 U5377 3 *1~.11~il hi t~7~ ~ 7'$ ~1996

OCR for page R1
~~I_~t-~ ~ilil~hit~l~iLS(ti;~Institute of Laboratory Animal Resources (11 ILAR2:will) ~ ~~lit~lo)~l:l~lt7~t~tt Guide for the Care and Use of Laboratory ArTinTals(l:ll~, With At, in'l~i:~Ctt: (~6 r W I ~ "'I.Y~th~i~==cc>~:J~l-l~:tR it" Guide for Laboratory Animal Facilities and Care ~ :~ j ~~ - -1963~.~ r.ii~w ~ i, )3 3 kl~i~i,ll~ _~ZF.o)~:iYk~6ht. 1996~*~riT~1i'~7~_td i i ;.. it- ~pGht_3~:, ~ii=.~f~-~t't:i~iF.r~: i t. ~t~il~ ,: i- hi_, J~-,. t3tht'i~ii-i~]L't_w~! ::~ ~ felon 3 .~.~.~.~h6. o ': ~f5S~^ tiTtTtii itch ~~ It Ate ~~fjb~T,,TIJ~ t~F31_~ i Sulfa (2l~:ki~rr3~) k:21, O)~'J4i'iTW i~. t~; i `-thli~iit:~-) ~ b~l:~:'~, ~ ~ ~ ~ ',-~ ~ ~ (~6 r >~2V'i~/~. that) +~h(~i~t~(T~]'>~2') -i~l i~i$a~o>~. ~t'h~:r~;b`~, ~~Ufl9~f] T >' f ' ~ ~ 3 :/ 1: I. /,-, ~ .-_ TIT in ~ in ~ ~.~ 3 b ~ ~ ~ ~ i ~ ~ ~ . 1~;t~:b~ :,(- r 6. >I i) ~ ~i)~1r~li*)Khit-fr~l~JbO4: trends: >_ ~ to b~i,'.s-. Ir itl]~(i~ir~ffT!bibO~2~21~. fig, !rTi1-..iv ~ ~ ~~j~( inert them _ 2: i~6'l~I~ ~ by A. It ~ ~ ~~:-)J~ff tail i < KnU~h; ~~ ~ 1:~ ~ ( 3 ID,). ~~j3l--t~ :~l ~ i: fit, ~,~T~bi l) ;, ~)if~If l:~th>~ thy Of ~ ^~ t~, ~ t~ j I ~ ~; j I ~f~Jl3~1~~ ~)~ll'~lil~t~Ti1-1:5Z~h~:1fi}:fi9~3hlLfiTt ,D,~ ~'J !: HIT, 1: :,h:. ~TiftlJ trTft 1] ~,T~9T~ ~ ~ |~ it ~ ~ ~ ~At. ~ ~ J~iD~a;TTt~!fisJT.i~7i:-a~, Tim'... t' G~I_iVT~-~bxL j it'-. Add.. ~~Y)~Ti~ L~:~ii(r~ (1)

OCR for page R1

OCR for page R1
thy ?: ~~ l_l&-ql:3~fitl t, 1996~1 hl 2 t3 l_; ~-bqq~'~?f fjol:7~J: ~7~iVIo~~, t)l$~L1 ]~:17i~Tib~Ltf>Et: (engineering approach) multi;Et:-L (performancegoal) ti~-~( . ~ ^3uf lo l t+.~3L. l t_ ~ at ~ i~ TR~$~ ~ l_ ~ ~ -'. i j-t<1b*l ~ ~ 2: iG 1_ thti/Jii'lit ~ ~ ~ ~ ~ t` Irafft~f~1-l ted C`~ JO qr.*ii' t-~. :h-. 't-h-ihI~'r~4rrftl-i'~'fRo~lt~. ho j ~,~t :~~ Amp, l~t.'t~t~,=~ J: ~'Tj'r?~rx~rld:, IN it~f~*r:~.rlr ~ 9 Mar * ~ 7 j l_~ t_ Al-** Other =r rr*~:e q~~t~*`tLrr~li~ht-. {hi_ Its. ho) ~~-~-'.=e.~9 i,~,i '. ~ at d>:iZ;~El_trtl.~ I t "~ilih~a~ )(i:~if1Y,~ sqr ~ f~ ~_,7~rq ~ g ~ry~r~L~`wi~yL Public Health Service Policy on Humane Care and Use of Laboratory Animalst g t~ l,t ''9vJ~w~lt~41 " Animal Welfare Regulations)It t~4Bl~l:~s 2, ).i, (h6)ilt~q~l~4l;q`_~sr~lt`-l,4. t t<*twitl_ itl9)~-~L~00 ~ ~ 7~ ~ t ~*`,~.~ ~ ht ): 1 r t. tli.=Oi. 39`lis~3lv~ti] 1_1,+~h ~Ithif~` ttfu~rt ~Nt ~r~g. ~, j ~`t=-l7ttrrit~f*~?77tl: rhthfShr~ g*~, 4$1 r7~r~iC~*~7~r~th.~.~ht . h6~l,':TEttu~ t _ LI_,i9. tLrrito~l~llst ~*~r'~tl_l~hO~i (i>0, r)~`rl,tg!~ ~rii~ (3)

OCR for page R1
/-~x~t~ ~ ~ ~ ~ePi~i~it4~I~ ~ r ~~ ~i. 7~ as. rival- *I iE`~n htYi,) 1- ~ l) lq64~1 i ~i~.~; tot_. tori ~ ~ :/~<~.~,~,! t~p'-5T;~. PxJII~ h= ~-~tr~l~il ;~:i F~7 77 ~ 6'~iPt 6. 1;~1 Trh~1~ii~t(_f~i.~.i:~x-,t_I:?:7'r /74~1~. ~x Tb#~t ~Fhl~. t: - lr~ili~g' 1~37~t~HDhiJ~sibI Rt:~ti>~xitrr Ph=-1 i i ~ 6. ~=fit~q~ttililt)~<~ii S. I~lT7hi ~)lifil-(-tXI~I~. it-g~ T~hi T * ~ r 11tt rit1:i~i~ t iY 1. i67hiF, ~ IT: ~ =t Ui~? I 7 ~ l - ldi l t f f itittl l: . ~J*~ i l~tiX~>BI~l<. *tA~(tiP7~ ;h8. ~nf~l~ilil~r;qf (12h2 h Bruce Albertst~L-t Harold Liebowithir. 1-~. (4)

OCR for page R1
r~ib$b) ~~ ~ ~~ {: ~~ ~ If, ~=nJ~ J. Derrell Clark (Chairman), University of Georgia. College of Veterh~ary Medicine, Athens, Georgia Ransom L. Baldwin, University of California. Davis. California Kathryn A. Bayne, American Association for Accreditation of Laboratory Animal Care. Rockville. Maryland '\larilyn J. Brown, Dartmouth College, Lebanon, New Hampshire G. F. Gebhart, University of Iowa, College of Medicine, Iowa City, Iowa Janet C. Gonder, Baxter Healthcare Corporation. Round Lake, Illinois Judith K Gwathmey, Harvard Medical School, Boston, Massachusetts Michale E Keeling, University of Texas M.D. Anderson Cancer Center, Bastrop, Texas Dennis F. Kohn, Columbia University, College of Physicians & Surgeons, New York, New York J. Wesley Robb, Professor Emeritus, University of Southern California, Los Angeles, California Orville A. Smith, University of Washington, Seattle, Washington Jo Ann D. Steggerda, Champaign, Illinois John G. Vandenbergh, North Carolina State University, Raleigh, North Carolina William J. White, Charles River Laboratories, Wilmington, Massachusetts Sarah Williams-Blangero, Southwest Foundation for Biomedical Research, San Antonio, Texas John L. VandeBerg, Southwest Foundation for Biomedical Research, San Antonio, Texas (ex of ficio member) Thomas L Wolfle, Program Director Carol M. Rozmiarek, Prolect Assistant Norman Gn~ssblatt, Editor (5)

OCR for page R1
~Y~q45f 37illitlCti~if~f'iiii~ John L. VandeBerg (Chairman). Southwest Foundation for Biomedical Research, San Antonio, Texas Christian R. Abee, University of South Alabama, Mobile, Alabama J. Derrell Clark, University of Georgia, College of Veterinary Medicine, Athens, Georgia Muriel T. Davisson, The Jackson Laboratory, Bar Harbor, Maine Bennett Dyke, Southwest Foundation for Biomedical Research, San Antonio, Texas Neal L. First, University of Wisconsin, Madison, Wisconsin James W. Glosser, 7Massilhm, ()hio John P. Hearn, Wisconsin Regional Primate Research Center, Madison Margaret S. Landi, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania Gail Martin, University of California, San Francisco, California Charles R McCarthy, Kennedy institute of Ethics, Georgetown University, Washington, D C. Robert J Russell, Harlan Sprague Dawley, Frederick, Maryland Richard C. Van Sluyters, University of California, Berkeley, California John G. Vandenbergh, North Carolina State University, Raleigh, North Carolina Peter A. Ward, University of Michigan Medical School, Ann Arbor, Michigan Thomas D. Pollard, The Johns Hopkins University School of Medicine, Baltimore, Maryland (ex officio member) ~41: Eric A. Fischer, Director Thomas L. Wolfle, Program Director Mara L. Glenshaw, Research Assistant Carol M. Rozmiarek, Project Assistant ~~lBlJ~filtiti~lnstitute of Laboratory Animal Resouces: ILAR!:;, 1~61 ;l Iffy t~'~O~-; 91952~1-=Rxit:~ht_, 7 f 71t f x>~ it Or, ff I, I, ifx~f~9dJ~ti76-l~t~fj~'t M'. ft~fFFh~Jft~-FFJ~:l~ Doff Pi , 177~of~i-~~~ It_ -7 rays. ~ f, r.Sr;~ ) OCR for page R1
Thomas D. Pollard tChainnan), The Johns Hopkins University School of Medicine, Baltimore, Maryland Frederick R. Anderson, Cadwalader, Wickersham & Taft, Washington, D.C. John C. Bailar, 111, McGill University, Montreal, Canada John E. Bums, Marine Biological Laboratory, Woods Hole, Massachusetts Michael T. Clegg, University of California, Riverside, California Glenn A. Crosby, Washington State University, Pullman, Washington Ursula W. Goodenoutah, Washington University, St. Louis, Missouri Susan E. Leeman, Boston University School of Medicine, Boston, Massachusetts Richard E. Lenski, Michigan State University, East Lansing, Michigan Thomas E. Lovejoy, Smithsonian institution, Washington, D.C. Donald R. Mattison, University of Pittsburgh, Pittsburgh, Pennsylvania Joseph E. Murray, Wellesley Hills, Massachusetts Edward E. Penhoet, Chiron Corporation, Emeryville, California Emil A. Pfitzer, Research institute for Fragrance Materials, inc., Hackensack, New Jersey Malcolm C. Pike, University of Southern California School of Medicine, Los Angeles, California Henry C. Pitot, 111, McArdle Laboratory for Cancer Research, Madison, Wisconsin Jonathan M. Samet, The Johns Hopkins University, Baltimore, Maryland Harold M. Schmeck, Jr., North Chatham, Massachusetts Carla J Shatz, University of California, Berkeley, California John L. VandeBerg, Southwest Foundation for Biomedical Research, San Antonio, Texas :: Paul Gilman, Executive Director (7)

OCR for page R1
~!ttilh~ ~-~?fr~ml-l~6fFfit Guide for the Care and Use of Laboratory Animals (1311:, tuft ~ Jam) 13:. 'x~lftJJY~i~ ~ ~ ~I~ 1~W fi At Guide for Laboratory Animal Facilities and Care? v~ -. ~ ~ -~1963~ TJJJ1K~h. ;1~, 1965l, 1968qt, 1972~, 1978~, 1985~1_:h~h~=~Tb; h046ht_. ~J:l)K40hikl31~11::t~bL:~-;>h, t)l~'T9~lTl~b~ LL.(J~<~ItAh~h:~. Cairo ~fl:~tJrt_7b~1~$1To ATd:~?hL91L -a Irr.l ~~ JO AS | Lid ~< A; S O. ~ O)lD27~1Y;3$~ ~!~I*? ~ 43 7 ~~ ~ 19966,~:ht_. LOLL, *Ikl)~61-li~;j:flJt #at As, ffl>t.~r~r#~Pfi9 (;t7~1~f7',~Jiq~ ''tar, t~ff)J~t7~-~It~ TV, t-~3~J> Oh 7_ - 7~.b';,~:f^~t- St~ ~~[~Ib.~>73 FF8,tPfra he ~ tori_, kfflih~s ~5 /ft~j Aim k~.~p~k~37 j ~ ski =0 4 Cab ;, ~ ~ ~ v 7, ~~ r3~:i #3, fi-'.-,h, ? ~~>s~r~l-,R~T; Pf~institutional animal care and use committee: IACUC, ~~G-+i ~ V<,fflt+;l~.T:h Kin; d7Sf l-~u~ |0. 4 =~i C<~r*r~: 1991~, '~fflsi7fflh'~s~il~it~b`3rrt? ~ t_~.t7~lJ~f- ~ Do- l A. 3rf i 1- ~ ~1~ J -A~~Z Z LO ~41~S~), 199341_3riftZ>5TZ~Fl~b$)KIT1~15~1~'~l-O449^ L;S tLt_, 15~0 f-rt.f~ r~j+~, Ji O :~S5ffl~fflih~t3f7llEl-~ffl. O iT34DY tSt3$iti Z ~ ]4+~ ~ 104~.rrfflSjh~13 ~Z We'd (LI (9)

OCR for page R1
i~=T~_~irt,. Irbf~t,)~.~.i>~L~FI~ T~414~:~-$C+OO..LZ) A< Bat . ~ t, 7i~ ~ AD C~1993*12H 1 R /-. ~ i) 7 t~- T)~1~1-t>77~i/~-1994*2M 2 IJ:_, _x' - 1)u)11~> F~4 :~.19944: 2 ~ 4 E] ;-(h~c'h?~.~g.~c~>t_, ~L~I]~.L<~:,ht~ A, gin V~6ht.~;~L, *~rfil-l~t aft_ ~L91~/~. ~~/_R.-~Ut William 1. Gaylt6 Bennett J. CohenK 1-~.~;~5. th~7~Animal Care Prine'~)~i~~~-.r. -.-.' Cohen J; 1959*i_, L~'q)~bjil~j) ~ to_, ~;.~;q ,~ i- I it 7~th8/-13~Lg~ Committee on Ethical Consideration in the Care of Laboratory Animal silt. ,rDl-~?L~5tO7}:L~t~Gaytt<~ to. ~1}, i~ft04: r ~ 0 :! 1~ ti7~~thIl~h~l~ tE=qo~:~h92~fi I]( ~ 7~- t'~_~t_ Art.. 2~., ~~;ti2~7~t_ ~~ t/_L2 ~Ris5~ 7 ion 1~, ~q-^FF~L~Professional Standards Co-- m free Arts Ut_. ,r4Yr~iFF3~tr/~:~R, Eih~7~-3E~t "'7~,E~$~'W(J~i P1h9~iL~Ut ~~:~ ~ 'J ~~ i_ . . e. ~ i. j~$ q-r.~ ~ ~L.4ie:~ t:~L~3.i~nimal Facilities Standards Committee> ~ 9, FR]~L~ / _ ~ ~ ~ ~ EN ~ ~ ~ ~ I -1~1 t ~ Tre fir ~7)b1iet :i)~ ok ~ h t_. jrat2tilk iT;~/t. ~~ Ed~5~7~1~ h ~ib~:~ l.r~>t t fit jh$jt; ~:~97AnimalWelfareInformationCentert. ~~fi-l~q~)~7~-lY1~- he National Agricultural Library, U. S. Department of Agriculture/-J7: < =~l_ir~p . Id. ~ ht. 2 ~L'q3~ti4~1thlo' At ~ 4r~/o7~` 6hq<~+ i 1-t~*'-~t_, ::61_, le~iitl~llD~-eatK. iie~31~ rig il.~ OCR for page R1
- ~ ~ - lE=~I-~t-~< i Tim A........... imp, 'IN ..................... fib~4!i ............... .................... ~~ .................. n~ .................. t~tt~ ............. = .............. ............................................................. 7 ~ 1 of: WF~ra9~$` ~ ~~ . ....... |~15E]~j5~ ~~ - I :] lt~m:_~J~Ffi~ (10) ~ !,. J .~ ~ Do. ~ ~~ -Patty ~~ (ll) q~l (12) ~fi~.:h-~h'ij~$4 . IVY ~k$q~ (13) ........................................... ~,~60~ ~ ~~ ............................................... = .................................................................... p ~ 1(7 .~ l ~ f 6: It I c nT f if ( 16 ) 5')~kF~ (17) 6')~ (17) In. 1~!1~ ~ ~ ~~ 1) ~ ~ (17 ~~'~i~h~ (18) I~1~ (19) Ro~fi~ (19) ........................ .... 9 14 14 15 ......................... 21 (11)

OCR for page R1
2 Ad. ~~, Q~ ~ tvc~ ................................ I .................................... 7r1,,:li:~ 7r~if& (24) t ~] (25) 23 ............ 24 -.i[~ ~ ~/fYi-i~i ^~ ~ 9~ limit/ ~ ~~,~( f~T~;7-; - 7.-1 i 6 Iriifl- (27) i, j I:g fi ~ Wi,~ (32) JO xt (33) ,~Q ~~ (36) ,77f Al (38) T;bb~ -............ i45ih'J6f7il: (38) -ill 5601 F~.fi~ (39) 1% Oh (40) ...................... fill HI- (41) i.. 7? (43) Id. 7'1 (44) 1- ~ - (44) r^:~.'~'x~/ :7 air 7)i~'1J~'1'414 Rex (47) 'i Oil . 'f,:j~il<~] it ,, Am, fir ~ ~~ (48) ~j ............................... f~ffti~SlI~ ~ 7,CiiLi~ (49) kf7 =~ i1,C~i~ (So) = ................................. (48) --- 38 41 ';>iti'(i iiC7~i-/ - -J~l~l~iXif i~iq/~/~:~fC 3 ~ ~~ 9~47)~A~- ~ Ui~ii~ ........... ................. (12) ............................. 49 ..................... 59 60

OCR for page R1
i> . 1~. ,~1512. ARES (61) I). ~1~, (n~/j'=t View (63) ~14~ jE .................................... it, Shah ~ Utah .................... ...................................................................... ,~+ ......................................................................... ~4~ ~ ~ apt ~ .... 71t~ .... (77) i'7 (77) 7: ~ (77) (78) 7\ (78) (78) Jo: (79) 3bl (79) ,Rd,H)] (80) ~~ ~~'( (81) ,~ E3 )~ (81) $77J~Di~i~'~ (81) ~e-$~,~ :~ - ......................................................................... .................. 61 64 - 67 69 70 ........................................................................ 75 .................................. - 76 ..................................................................... 77 446tA: M ........... {RIB: ~~l:~t~ .................. {TIC: ~~:~ 14~ D: ~~ ~ ~~ i: ~ J ~~a 82 84 85 .......... 106 ,, 119 -- 121 ..................... 124 (13)