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Review of the Department of Defense Research Program on Low-Level Exposures to Chemical Warfare Agents
tion. The time, money, and effort could be better used in focusing on the most important and promising animal models and toxicity end points. The operational relevance of the research in terms of relevant durations of exposure and CWA concentrations must be considered in establishing research priorities.
To obtain the information most valuable in protecting military personnel from operationally significant performance decrements or potential delayed adverse health effects after short-term exposure to low concnetrations of CWAs, DOD should ensure that the total database from previous human and animal studies has been fully examined to fill data gaps. These studies include human studies, nonhuman primate studies, toxicokinetic studies, and the studies used to derive NRC’s AEGLs.