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OCR for page 102
Review of the Department of Defense Research Program on Low-Level Exposures to Chemical Warfare Agents Abbreviations α alpha AChE acetycholinesterase AEGL acute exposure guideline level β beta C concentration CNS central nervous system Ct product of concentration and time CV conduction velocity CWA chemical warfare agent DAAMS depot area air monitoring system DFP diisopropyl fluorophosphates DNA dexyribonucleic acid DOD U.S. Department of Defense EC01 effective concentration estimated to be in 1% of the dosed animals ECT50 the concentration and time estimated to be that causes an effect in 50% of subjects ED50 dose estimated to be effective in 50% of the exposed individuals EEG electroencephalogram FDA Food and Drug Administration GA tabun GB sarin GC gas chromotography
OCR for page 103
Review of the Department of Defense Research Program on Low-Level Exposures to Chemical Warfare Agents GD soman GF cyclosarin GLP good laboratory practice HD sulfur mustard IU/L international units per liter L liter LC50 concentration estimated to be lethal to 50% of subjects LCt50 lethal (estimated to be) concentration-time relationships in 50% of subjects LD50 dose estimated to be lethal to 50% of subjects MAP2 mitogen-activated protein MEGs military exposure guidelines mg milligram mL milliliter MOPP mission-oriented protective posture MRI magnetic resonance imaging mRNA messenger ribonucleic acid MS mass spectroscopy MTD maximum tolerated dose NRC National Research Council ORM operational risk management OP organophosphate PAC presidential advisory committee PBPD physiologically based pharmacodynamic PBPK physiologically based pharmacokinetic PON1 paraxonase 1 REM rapid eye movement RNA ribonucleic acid SFEMG single fiber electromyography t exposure time µg/kg microgram per kilogram µm micrometer µM micromole USACHPPM United States Army Center for Health Promotion and Preventive Medicine WPAFB Wright-Patterson Air Force Base
OCR for page 104
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