1. Genes and gene regulatory sequences: (“nucleic acid” OR nucleotide OR “nucleotide sequence” OR oligonucleotide OR deoxyribonucleic OR deoxyribonucleotide OR oligoribonucleotide OR ribonucleotide OR “recombinant DNA” OR cDNA OR plasmid OR gene OR genomic) AND (“promoter” OR “enhancer” OR “response element” OR “DNA motif” OR “DNA binding” OR “upstream region”)


2. SNPs and/or haplotypes: (Haplotype OR Polymorphism OR “single nucleotide polymorphism” OR “variable number of tandem repeat polymorphisms” OR “tandem repeats” OR “microsatellite polymorphisms” OR allele OR “genotypic variation” OR “genetic locus” OR “DNA polymorphism” OR “restriction fragment length polymorphism”)


3. Gene expression profiles/profiling: (“nucleic acid” OR nucleotide OR “nucleotide sequence” OR oligonucleotide OR deoxyribonucleotide OR “recombinant DNA” OR cDNA OR plasmid) AND (“gene expression profile” OR detection OR array OR screen OR “microarray” OR diagnostic OR treatment)


With U.S. class restriction: 800* OR 435* OR 424* OR 535* OR 935* OR 530* OR 514* OR 436*


4. Protein structure: (protein OR polypeptide OR oligopeptide or proteome OR protease OR enzymatic OR “enzymatic polypeptide” OR peptide OR “protein complex” OR “protein domain” OR PDB OR “protein data bank” OR motif OR antibody OR antibodies or enzyme) AND (“three-dimensional structure” OR angstrom OR “atomic coordinate” OR coordinate OR “space group” OR “binding pocket” OR “binding domain” OR “fold space” OR “modeling test compounds”) AND (“mass spectroscopy” OR MS OR “mass spectrometry” OR crystallography OR crystallographic OR NMR OR “nuclear magnetic resonance” OR “x-ray crystallography” OR “crystal structure” OR “computational modeling” OR “computer readable storage medium” OR algorithm OR “crystalline form” OR “in silico screening” )


5. Protein-protein interactions: (protein OR polypeptide OR oligopeptide OR peptide OR proteome OR protease OR enzymatic OR “enzymatic polypeptide” OR peptide OR “protein complex” OR “protein domain” OR PDB OR “protein data bank” OR motif OR antibody OR antibodies OR enzyme OR factor OR homolog OR homologue OR analog OR analogue OR ortholog OR orthologue) AND (“interaction partner” OR ((“protein-protein” OR “protein-DNA” OR “DNA-protein”) AND (binding or interaction or assembly)) OR “receptor-ligand” OR ((binding OR interaction OR interacting OR active) AND (domain OR site OR region OR pocket)) OR “receptor-agonist” OR “receptor/agonist” OR “re-



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