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Application of Toxicogenomics to Cross-Species Extrapolation
Appendix A WORKSHOP AGENDA
Applications of Toxicogenomics to Cross-Species Extrapolation: A Workshop
Despite the dependence on animal models in toxicologic research for predicting human health effects in the regulatory arena, there can be significant differences between how animals and humans respond to different chemicals. This workshop will consider promises and limitations in using emerging high-throughput approaches, such as genotyping (genomics), mRNA analysis (transcriptomics), protein analysis (proteomics), and metabolite analysis (metabolomics), to inform cross-species extrapolation.
Thursday, August 12th 2004
9:00 am
Welcome and Overview of the Workshop, including what is meant by “Cross-Species Extrapolation”—Leigh Anderson/ David Eaton
9:10 am
Richard Di Giulio, Duke University
Highlights from a Recent Pellston Workshop on Emerging Molecular and Computational Approaches for Cross-Species Extrapolation
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Application of Toxicogenomics to Cross-Species Extrapolation
Appendix A
WORKSHOP AGENDA
Applications of Toxicogenomics to Cross-Species Extrapolation: A Workshop
Despite the dependence on animal models in toxicologic research for predicting human health effects in the regulatory arena, there can be significant differences between how animals and humans respond to different chemicals. This workshop will consider promises and limitations in using emerging high-throughput approaches, such as genotyping (genomics), mRNA analysis (transcriptomics), protein analysis (proteomics), and metabolite analysis (metabolomics), to inform cross-species extrapolation.
Thursday, August 12th 2004
9:00 am
Welcome and Overview of the Workshop, including what is meant by “Cross-Species Extrapolation”—Leigh Anderson/ David Eaton
9:10 am
Richard Di Giulio, Duke University
Highlights from a Recent Pellston Workshop on Emerging Molecular and Computational Approaches for Cross-Species Extrapolation
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Application of Toxicogenomics to Cross-Species Extrapolation
9:35 am
William Benson, U.S. Environmental Protection Agency
Potential Implications of Genomics for Regulatory and Risk Assessment Applications at EPA
10:00 am
Discussion of Issues Raised by Di Giulio and Benson
10:30 am
BREAK
10:40 am
Frank Witzmann, Indiana University
Technological Challenges of Cross-Species Extrapolation Using Proteomics
11:10 am
Donna Mendrick, Gene Logic
Modeling Gene Expression Data to Predict Human Hepatotoxicity Following Inconsistent Animal Responses
11:40 am
Discussion of Talks
12:00 pm
LUNCH
1:00 pm
Susan Sumner, Paradigm Genetics
Using Metabolomics/-omics to Explore Species Differences in Metabolism and Distribution
1:30 pm
Russell Thomas, CIIT Centers for Health Research
A Systems Biology Approach to Cross-Species Extrapolation
2:00 pm
Discussion of Talks
2:20 pm
BREAK
2:30 pm
Stephen Nesnow, U.S. Environmental Protection Agency
Combining Transcriptional and Toxicologic Approaches to Understanding the Basis of Species Differences in Conazole Carcinogenesis
3:00 pm
John Butenhoff, 3M Co.
Species Differences in Response to Perfluorooctanoic Acid
3:30 pm
Discussion of Talks
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Application of Toxicogenomics to Cross-Species Extrapolation
3:50 pm
BREAK
4:00 pm
Roundtable Discussion—questions such as:
• “Once a molecular basis for understanding a species differences has been established, what are the challenges to incorporating -omics information about species differences into the regulatory framework?”
• “What are the advantages to using -omics compared to other approaches for detecting or explaining cross-species differences?”
• “How much data are sufficient for arguing that a particular mode of action is most relevant to humans?”
5:00 pm
ADJOURN
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