late-pregnancy, 37, 46

live, CDC rules on the importation of, 18–20

natural enemies, 79

preconditioning, 59

segregation of, 71, 78–79

small, 38–39, 42, 56

Animals/animal products

with radioactive/poisonous material, federal statutes/programs relevant to the transportation of in the United States, 12–13

with zoonotic/infectious diseases, federal statutes/programs relevant to the transportation of in the United States, 12–13

Anorexia, 54

APHIS. See Animal and Plant Health Inspection Service

Aquatic Animal Health Code, 28

Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC), 9

Asymptomatic disease, 65, 69

Autoclaving, 77

avoiding, 76

Avian influenza A (H5N1), 19, 28–29

Avian species, 84

AVMA. See American Veterinary Medical Association

AWA. See Animal Welfare Act

B

B virus, 70

Bacteria

requiring facility registration with CDC, 67

and the susceptible species of research animals, 74–75

zoonotic diseases transmissible from research animals to humans, 69

Barrier containment, 71, 76–77

Bats, live, 20

Behavioral and physiological signs of thermal status, 52

Behavioral monitoring of thermal environment, 51

Biocontainment, 88

Biomedical research

federal funding for, 7, 20

use of nonhuman primates in, 24

Biomedical research enterprise, 1

Biosafety in Microbial and Biomedical Laboratories Manual (BMBL), 66, 71

Biosecurity, 65–79

protecting public health and agricultural resources, 66–71

protecting the biological integrity of research animals and colonies, 71–79

Bioterrorism agents, 65

Bioterrorism Preparedness and Response Act, 66

Bird flu, 19

BMBL. See Biosafety in Microbial and Biomedical Laboratories Manual

Breeders, commercial, 7–8

C

California Department of Health Services, 22

Candidate set for the facility-location problem, 121

Care in transit

for dogs and cats, 103–104

for guinea pigs and hamsters, rabbits, and other animals, 115

for nonhuman primates, 109

Carriers, third-party, 9

Cats. See Dogs and cats

CDC. See Centers for Disease Control and Prevention

Center for Veterinary Medicine, 22

Centers for Disease Control and Prevention (CDC), 7, 18–20, 66, 71, 85n, 86

agents and toxins that require registration of a facility with, 67

Division of Global Migration and Quarantine, 8–9, 12–13, 19

Etiologic Agent Import Permit Program, 12–13, 20

Centers for Disease Control and Prevention (CDC) regulations and guidelines for the transportation of research animals, 18–20

importation and transportation of etiological agents, 20

importation of live animals, 18–20

Certifications, 101, 107

CFR. See Code of Federal Regulations

Checklist, of research animal regulations and guidelines, 31–32

Chicago, IL, 9

Front Matter (R1-R22)

Summary (1-6)

1 Introduction (7-10)

2 Regulations and Guidelines for the Transportation of Research Animals (11-32)

3 Good Practices in the Transportation of Research Animals (33-64)

4 Biosecurity (65-80)

5 Recommendations (81-88)

References (89-96)

Appendix A: Summary of the Animal Welfare Act Regulations Pertaining to Transportation (97-116)

Appendix B: Patterns in the Ground Transportation of Research Animals in the United States (117-126)

About the Authors (127-130)

Index (131-142)