and globally. This global dispersion is being driven by a multitude of economic, social, and political forces. Chapter 3 provides an overview and perspective on the breadth and types of technologies that will—directly or indirectly—have an impact on how the life sciences enterprise will evolve in the near-term future. Finally, Chapter 4 presents the committee’s conclusions and recommendations about the ways in which the adoption of a “web of prevention” approach might enhance our collective abilities to mitigate or minimize the negative consequences of inadvertent, inappropriate or purposeful malevolent applications of any of these technologies in the decades to come.

ENDNOTES

1  

Cracraft, J. 2004. Editorial: A new AIBS for the age of biology. BioScience (November). Available online at www.aibs.org/bioscience-editorials/editorial_2004_11.html [accessed January 4, 2006].

2  

Meselson, M. 1999. The problem of biological weapons. Presentation given to the 1818th Slated Meeting of the American Academy of Arts and Sciences, Cambridge, MA, January 13.

3  

National Intelligence Council. 2004. Mapping the Global Future, Report of the National Intelligence Council’s 2020 Project. Available online at www.cia.gov/nic/NIC_globaltrend2020.html#contents [accessed May 3, 2005].

4  

National Research Council. 2004. Biotechnology Research in an Age of Terrorism. Washington, DC: The National Academies Press.

5  

Couzin, J. 2002. Breakthrough of the year: small RNAs make big splash. Science 298(5602):2296-2297. Available online at http://www.sciencemag.org/cgi/reprint/298/5602/2296.pdf [accessed January 4, 2006].

6  

Cancer Bulletin, National Cancer Institute. 2005. “Cancer biologists are using RNAi to do everything from investigating individual genes to running high-throughput screens for new drugs to developing therapeutics,” says Dr. Natasha Caplen, head of the Gene Silencing Section in NCI’s Center for Cancer Research. Available online at www.nci.nih.gov/ncicancerbulletin/NCI_Cancer_Bulletin_032905/page4 [accessed January 4, 2006].

7  

10 emerging technologies that will change your world. Technology Review (February 2004). Available online at www.lib.demokritos.gr/InTheNews/emerging0204.htm [accessed January 4, 2006].

8  

Scherr, M. et al. 2003. Inhibition of GM-CSF receptor function by stable RNA interference in a NOD/SCID mouse hematopoietic stem cell transplantation model. Oligonucleotides 13:353-363; Song, E. et al. 2003. RNA Interference targeting Fas protects mice from fulminant hepatitis. Nature Medicine 9(3):347-351; Soutschek, J. et al. 2004. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432(7014):173-178.

9  

Frost & Sullivan. 2004:B349.

10  

Ibid.

11  

10 emerging technologies that will change your world Technology Review



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