J. EDWARD PUZAS is the Donald and Mary Clark Professor of Orthopaedics at the University of Rochester School of Medicine and Dentistry. He also holds faculty appointments in biochemistry, biomedical engineering, oncology, and pathology and laboratory medicine. He is director of the university’s Osteoporosis Center and Center for Musculoskeletal Research. His research interests are in all aspects of bone, cartilage, orthopaedic, and dental biology, with a particular interest in diseases of the skeleton, such as osteoporosis and some skeletal cancers. He also directs the osteotoxicology research core at the university’s National Institutes of Environmental Health Sciences center program at the University of Rochester Medical Center, where he conducts research on adverse impacts of environmental agents on skeletal tissue. He has won several awards for his research, including the Kappa Delta Prize for Outstanding Orthopaedic Research and the Kroc Foundation Award for Excellence in Cartilage and Bone Research. Dr. Puzas is president of the Orthopaedic Research Society. He received his M.S. and Ph.D. in radiation biology and biophysics from the University of Rochester.

NU-MAY RUBY REED is a staff toxicologist with the California Environmental Protection Agency’s (Cal/EPA) Department of Pesticide Regulation, where she is the lead person on risk assessment issues in the health assessment section. Her research interests are in evaluating health risks and developing dietary assessment guidelines for pesticides. She has been on several Cal/EPA working groups that initiate, research, and revise risk assessment guidelines and policies, and she represented her department in task forces on community concerns and emergency response, risk management guidance, and public education. Dr. Reed is also a lecturer on health risk assessment at the University of California at Davis. She received her Ph.D. from the University of California at Davis and is a diplomate of the American Board of Toxicology.

KATHLEEN M. THIESSEN is a senior scientist at SENES Oak Ridge, Inc., Center for Risk Analysis. She has extensive experience in evaluating exposures, doses, and risks to human health from environmental contaminants and in using uncertainty analysis for environmental and health risk assessment. More recently, Dr. Thiessen has led a working group on dose reconstruction for the International Atomic Energy Agency’s Biosphere Modeling and Assessment Methods program. She received her Ph.D. in genetics from the University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences.

THOMAS WEBSTER is assistant professor in the Department of Environmental Health at the Boston University School of Public Health. His

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