|
Species and Strain
|
Exposure Conditions
|
Fluoride Concentration or Dosea
|
Exposure Duration
|
Effects
|
Reference
|
|
Rats (Hebrew University albino, males; infants at start, 30-32 g)
See also Table E-16
|
Drinking water
|
0.55, 1, or 10 mg/L (0.055, 0.1, and 1 mg/kg/day)b
|
9 months
|
No significant differences in basal metabolic ratio, thyroid weight, radioiodine uptake, total blood iodine, protein-bound iodine, or urinary excretion.
TSH not measured.
|
Gedalia et al. 1960
|
|
Rats (females, 180-230 g)
|
Gastric tube 0.2 or 2.2 µg/day iodine in diet
|
750 µg/day in 1 mL water (3.3-4.2 mg/kg/day)
|
2 months
|
No effect of fluoride on body weight, weight of thyroid, total composition of iodinated amino acids, or amount of iodide present in the thyroid. No effect of fluoride on iodine excretion in the higher-iodine group.
Decreased protein-bound iodine, T3, and T4 (low-iodine group).
Decreased biogenesis of T3 and T4 following administration of131I (low- and high-iodine groups).
TSH not measured.
|
Stolc and Podoba 1960
|
|
Rats (Wistar, males; initial weight 170-230 g; 13 per group)
|
Drinking water Dietary iodine, 0.45 µg/g feed (0.45 ppm)
|
0, 0.1, or 1 mg/day (0, 0.43-0.59, or 4.3- 5.9 mg/kg/day)
|
60 days
|
Decreased plasma T3 and T4, decreased free T4 index, increased T3-resin uptake (all changes statistically significant except for the decrease in T3 for the group receiving 0.1 mg/day)c
TSH not measured.
|
Bobek et al. 1976
|
