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Review of the Department of Energy's Genomics: GTL Program (2006)

Chapter: Appendix D Examples of Research in Microbial Genomics Supported by Federal Agencies Other than the Department of Energy

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Suggested Citation:"Appendix D Examples of Research in Microbial Genomics Supported by Federal Agencies Other than the Department of Energy." National Research Council. 2006. Review of the Department of Energy's Genomics: GTL Program. Washington, DC: The National Academies Press. doi: 10.17226/11581.
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Appendix D
Examples of Research in Microbial Genomics Supported by Federal Agencies Other Than the Department of Energy

Agencies

Microbial Genomics Program

Department of Defense (DOD), jointly with National Institutes of Health (NIH) and Wellcome Trust and Burroughs Wellcome Fund

Sequencing of entire genome of malaria parasite Plasmodium falciparum

DOD in collaboration with Department of Energy (DOE) and NIH

Sequencing of entire genome of Bacillus anthracis

Department of the Interior (DOI)

Microbial research in natural resources, for instance, to identify microorganisms to control invasive species or to treat municipal sludge

Suggested Citation:"Appendix D Examples of Research in Microbial Genomics Supported by Federal Agencies Other than the Department of Energy." National Research Council. 2006. Review of the Department of Energy's Genomics: GTL Program. Washington, DC: The National Academies Press. doi: 10.17226/11581.
×

Agencies

Microbial Genomics Program

Environmental Protection Agency (EPA)

Research on harmful and beneficial microorganisms found in environment, including microorganisms that are harmful to humans (mold and biofilms in water systems) or are involved in cleaning up environment (toxins removed from wetlands, microorganisms that can remove chlorinated solvents and other organics, or microorganisms that can sequester heavy metals, such as lead)

Food and Drug Administration (FDA)

Research and surveillance on microbial pathogens, research to develop rapid assessment technologies for pathogens and treatment strategies, and work on antibiotic resistance

National Aeronoutics and Space Administration (NASA)

Research on functional genomics of organisms in extreme environments to understand nature of life and to ensure human health during space travel

National Institute of Standards and Technology (NIST)

Genomics research (bioinformatics, managing data banks, and structural genomics), research in such applied fields as biological production of chemical products that are more economical and environmentally friendly, and protein engineering

National Institutes of Health (NIH)

Microbial research that addresses human health issues—disease-causing microorganisms, Human Genome Project, yeast research, and computational biology to support genome-enabled science

Suggested Citation:"Appendix D Examples of Research in Microbial Genomics Supported by Federal Agencies Other than the Department of Energy." National Research Council. 2006. Review of the Department of Energy's Genomics: GTL Program. Washington, DC: The National Academies Press. doi: 10.17226/11581.
×

Agencies

Microbial Genomics Program

National Oceanic and Atmospheric Administration (NOAA)

Microbial research in support of sustaining healthy coasts and sustainable fisheries and work on microbial pathogens (algal blooms, parasites, and bacteria)

National Science Foundation (NSF)

Microbial research through a number of foundationwide initiatives and through unsolicited proposals and research on computational biology and bioinformatics

U.S. Department of Agriculture (USDA)

Microbial genomics that is relevant to mission of addressing regional and national problems and opportunities relevant to agriculture, food, forestry, and environment; and efforts to sequence animal and plant pathogens

Suggested Citation:"Appendix D Examples of Research in Microbial Genomics Supported by Federal Agencies Other than the Department of Energy." National Research Council. 2006. Review of the Department of Energy's Genomics: GTL Program. Washington, DC: The National Academies Press. doi: 10.17226/11581.
×

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Suggested Citation:"Appendix D Examples of Research in Microbial Genomics Supported by Federal Agencies Other than the Department of Energy." National Research Council. 2006. Review of the Department of Energy's Genomics: GTL Program. Washington, DC: The National Academies Press. doi: 10.17226/11581.
×
Page 87
Suggested Citation:"Appendix D Examples of Research in Microbial Genomics Supported by Federal Agencies Other than the Department of Energy." National Research Council. 2006. Review of the Department of Energy's Genomics: GTL Program. Washington, DC: The National Academies Press. doi: 10.17226/11581.
×
Page 88
Suggested Citation:"Appendix D Examples of Research in Microbial Genomics Supported by Federal Agencies Other than the Department of Energy." National Research Council. 2006. Review of the Department of Energy's Genomics: GTL Program. Washington, DC: The National Academies Press. doi: 10.17226/11581.
×
Page 89
Suggested Citation:"Appendix D Examples of Research in Microbial Genomics Supported by Federal Agencies Other than the Department of Energy." National Research Council. 2006. Review of the Department of Energy's Genomics: GTL Program. Washington, DC: The National Academies Press. doi: 10.17226/11581.
×
Page 90
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The U.S. Department of Energy (DOE) promotes scientific and technological innovation to advance the national, economic, and energy security of the United States. Recognizing the potential of microorganisms to offer new energy alternatives and remediate environmental contamination, DOE initiated the Genomes to Life program, now called Genomics: GTL, in 2000. The program aims to develop a predictive understanding of microbial systems that can be used to engineer systems for bioenergy production and environmental remediation, and to understand carbon cycling and sequestration. This report provides an evaluation of the program and its infrastructure plan. Overall, the report finds that GTL’s research has resulted in and promises to deliver many more scientific advancements that contribute to the achievement of DOE’s goals. However, the DOE’s current plan for building four independent facilities for protein production, molecular imaging, proteome analysis, and systems biology sequentially may not be the most cost-effective, efficient, and scientifically optimal way to provide this infrastructure. As an alternative, the report suggests constructing up to four institute-like facilities, each of which integrates the capabilities of all four of the originally planned facility types and focuses on one or two of DOE’s mission goals. The alternative infrastructure plan could have an especially high ratio of scientific benefit to cost because the need for technology will be directly tied to the biology goals of the program.

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