Raul Andino is Professor of Microbiology and Immunology at the University of California, San Francisco (UCSF). Dr. Andino joined the Department of Microbiology and Immunology at the University of California, San Francisco in 1992 and began a program to develop RNA viruses as vaccine vectors. His laboratory is interested in the fundamental questions of how viruses cause disease and how the host defends itself against viruses. He has continued an intensive investigation of RNA virus replication and has discovered an important connection between viral replication and viral translation. More recently, his laboratory has begun investigating the potential use of RNA mutagens and RNA interference as antiviral drugs. Dr. Andino has published over 50 papers in prestigious journals, co-directs a graduate course in animal viruses at UCSF, is a member of the editorial boards of the Journal of Virology and Virology, and is the recipient of an Eli Lilly award in microbiological research and a Science Award from the Cancer Federation. Dr. Andino has served on numerous advisory committees to the NIH including study sections and strategic planning for the AIDS vaccine program at NIAID. He received his B.S. in Microbiology and his Ph.D. in Chemistry from the University of Buenos Aires. He completed his postdoctoral work with Nobel laureate David Baltimore at the Whitehead Institute, MIT and at Rockefeller University from 1986-1992.

Diane Joseph-McCarthy is a Principal Research Scientist in the Structural Biology and Computational Chemistry Division of the Chemical and Screening Sciences Department at Wyeth Research. Her research interests are in the general area of molecular recognition and include virtual screening, structure-based drug design, and computational methods. Dr. Joseph-McCarthy received her bachelor degree in Chemistry with a minor in Computer Science from Boston University and her doctorate degree in Physical Chemistry from MIT. While at MIT, she worked with Professors Gregory A. Petsko and Martin Karplus (Harvard University) and used computational approaches to study the reactivity of the enzyme triosephosphate isomerase. Following her Ph.D. dissertation, she was a Research Fellow in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School. This research involved the use and development of new computational methods for the design of small combinatorial libraries of capsid-binding ligands for poliovirus and the related rhinovirus. Dr. Joseph-McCarthy has been the recipient of postdoctoral fellowships from the Radcliffe Bunting Institute, the Charles A. King Medical Founda-

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