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Preterm Birth: Causes, Consequences, and Prevention (2007)
Board on Health Sciences Policy (HSP)

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. "Summary." Preterm Birth: Causes, Consequences, and Prevention. Washington, DC: The National Academies Press, 2007.

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Preterm Birth: Causes, Consequences, and Prevention

only a few basic indicators related to the timing and content of prenatal care and the birth outcome.

In general, large variations in outcomes exist across NICUs that cannot be explained by patient mix or other readily observable hospital characteristics, such as patient volume and level of care. Recent research has suggested a role for the organizational and management structures of NICUs in ensuring good patient outcomes (Pollack et al., 1993). More research on the determinants of high-quality care will be needed to be able to send patients to the best hospitals.


Recommendation V-2: Establish a quality agenda. Investigators, professional societies, state agencies, payors, and funding agencies should establish a quality agenda with the intent of maximizing outcomes with current technology for infants born preterm.


This agenda should:


  • Define quality across the full spectrum of providers who treat women delivering preterm and infants born preterm;

  • Identify efficacious interventions for preterm infants and identify the quality improvement efforts that are needed to incorporate these interventions into practice; and

  • Analyze variations in outcomes for preterm infants among institutions.


5. Investigate the Impact of the Health Care Delivery System on Preterm Birth


Policy makers have focused on expansion of access to prenatal care since the 1980s in an effort to improve birth outcomes in general, including a reduction in preterm birth rates. These efforts have primarily been achieved through the expansion of Medicaid eligibility for pregnant women at the state level. A direct link between the availability of increased insurance and the receipt of early prenatal care was demonstrated in a study of Medicaid expansion in Florida (Long and Marquis, 1998).

Alternately, states can increase access to prenatal care outside of the confines of Medicaid by expanding programs that target uninsured pregnant women to provide them with access to prenatal care through Maternal and Child Health block grants (Schlesinger and Kornesbusch, 1990). Coverage for prenatal care services has also been extended through expansion of the State Children’s Health Insurance Program (SCHIP) [Title XXI, Social Security Act, Pub. I, No. 74-271 (49 Stat 620) (1935)].

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Front Matter (R1-R18)
Summary (1-30)
1 Introduction (31-52)
SECTION I Measurement : 2 Measurement of Fetal and Infant Maturity (53-83)
Section I Recommendations (84-86)
SECTION II Causes of Preterm Birth: 3 Behavioral and Psychosocial Contributors to Preterm Birth (87-123)
4 Sociodemographic and Community Factors Contributing to Preterm Birth (124-147)
5 Medical and Pregnancy Conditions Associated with Preterm Birth (148-168)
6 Biological Pathways Leading to Preterm Birth (169-206)
7 Role of Gene-Environment Interactions in Preterm Birth (207-228)
8 Role of Environmental Toxicants in Preterm Birth (229-254)
Section II Recommendations (255-258)
SECTION III Diagnosis and Treatment of Preterm Labor: 9 Diagnosis and Treatment of Conditions Leading to Spontaneous Preterm Birth (259-307)
Section III Recommendations (308-310)
SECTION IV Consequences of Preterm Birth: 10 Mortality and Acute Complications in Preterm Infants (311-345)
11 Neurodevelopmental, Health, and Family Outcomes for Infants Born Preterm (346-397)
12 Societal Costs of Preterm Birth (398-429)
Section IV Recommendations (430-432)
SECTION V Research and Policy: 13 Barriers to Clinical Research on Preterm Birth and Outcomes of Preterm Infants (433-454)
14 Public Policies Affected by Preterm Birth (455-472)
Section V Recommendations (473-476)
15 A Research Agenda to Investigate Preterm Birth (477-492)
References (493-590)
Appendix A Data Sources and Methods (591-603)
Appendix B Prematurity at Birth: Determinents, Consequences, and Geographic Variation (604-643)
Appendix C A Review of Ethical Issues involved in Premature Birth (644-687)
Appendix D A Systematic Review of Costs Associated with Preterm Birth (688-724)
Appendix E Selected Programs Funding Preterm Birth Research (725-731)
Appendix F Committee and Staff Biographies (732-740)
Index (741-772)