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Preterm Birth: Causes, Consequences, and Prevention
TABLE B-5 Immutable Medical Risk Factors Associated with Preterm Birth
Previous low birth weight or preterm delivery
Multiple 2nd trimester spontaneous abortion
Prior first trimester induced abortion
Familial and intergenerational factors
History of infertility
Nulliparity
Placental abnormalities
Cervical and uterine anomalies
Gestational bleeding
Intrauterine growth restriction
In utero diethylstilbestrol exposure
Multiple gestations
Infant sex
Short stature
Low prepregnancy weight/low body mass index
Urogenital infections
Preeclampsia
research on the efficacy of antibiotic therapy for the prevention of preterm delivery from these infections continues.
Demographic risks associated with preterm delivery include African American race, single marital status, low socioeconomic status, maternal age, and others (Table B-6). Although demographic factors cannot cause the premature expulsion of a fetus, these factors may antagonize some other risk factor(s).
Social, behavioral, stress, and maternal psychological factors have frequently been linked to pregnancy outcomes; and chronic stress has been related to low socioeconomic status (57–66). There have been difficulties in measuring the amount of stress caused by life events, but consistent associations between perceived stress and preterm birth have been reported.
TABLE B-6 Demographic Risk Factors Associated with Preterm Birth