Perhaps the greatest impact of the $1.4 million Markey award was the leveraging of additional funding: a five-year training grant from NSF, which required matching funds for consideration; an NIH training grant; and a March of Dimes endowment of $5 million to support training and research. The Markey funds were the main stimulus to allow initiation of a new graduate program in Developmental Biology. From its beginning the program increased to 24 faculty and 16 graduate students at the end of Markey funding.
Markey funding has been used to continue support of graduate students. In addition, funding has been used to establish a series of lectures by distinguished guest speakers. Finally, Markey funds supported part of the salary of a program administrator who coordinated the daily activities of the program in developmental biology.
Brandeis proposed establishing a protein crystallography laboratory to complement existing facilities for x-ray diffraction, electron microscopy, and computer graphics. Funds were required for spectroscopy, protein sequencing, and peptide synthesis. A particular feature of the new initiative was the incorporation of a postdoctoral exchange program between the Brandeis Laboratory and the Laboratory of Molecular Biology at the University of Cambridge. In 1998 Brandeis was awarded $2 million over five years, including approximately $1 million in salaries for three investigators. Funds totaling $500,000 were sought for technical personnel for the first three years and approximately $500,000 for crystallographic equipment. Brandeis was awarded supplemental awards of $500,000 in both 1990 and 1996. The former was directed to the activities of the structural biology and biochemistry group under the direction of Laura Davis; the latter supported the research of Lizabeth Hedstrom, a professor of biochemistry.
Gregory Petsko was the principal investigator of the Markey award. The award, and the supplements, was used to fund the research of a number of investigators. Principal among them are Hugh Huxley, Laura Davis, and Lizabeth Hedstrom.
Professor Hugh Huxley’s research focused on the use of x-ray syn-