public-sector vaccine development, biologic products research and development (vaccinology), military research and development programs, tropical medicine, and public health.

The task statement presented to the committee was as follows:

  1. Determine whether the DoD malaria vaccine research and development program is scientifically sound and able to achieve the vaccine program objectives within specified timelines. Assessments will include research and development strategy, management, budget, research staff (size and capabilities), research equipment, communications, and identification of potential barriers impeding research progress.

  2. Given that significant barriers are identified, recommend how to overcome them.

  3. Identify the major strategic goals and timelines based on the material received and presentations made by the DoD’s program representatives, and recommend ways and means to improve the likelihood of achieving them. This may include, as appropriate, recommendations for an optimal configuration of program elements.

  4. Recommend any additional studies or actions that the DoD malaria vaccine program could undertake to enhance its program, including the timing and priority of such efforts.

The IOM committee convened twice in person and twice by tele-conference during the period of the 6-month study. Their first meeting lasted 2.5 days, and the committee reviewed in detail the MIDRP malaria vaccine research and development program, its historical development, its current research efforts and budget, and its goals and objectives as presented by key MIDRP research staff. The USAMRMC also posed additional questions that it wished the IOM to address. An outside presenter (Dr. Filip Dubovsky of the Malaria Vaccine Initiative [MVI]) was also invited to give a global nonmilitary perspective. The IOM committee convened a closed session to deliberate and outline the programmatic review findings and proposed recommendations. At the second meeting, the committee reviewed a draft report and prepared its findings and recommendations. The committee report was subject to external peer review, in accordance with the usual IOM procedures, prior to final approval for release.

The committee was able to build on some earlier work, including a 1996 IOM workshop report entitled Vaccines Against Malaria: Hope in a Gathering Storm that was prepared for a consortium of federal and private

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