Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program (2006)

Since 1990, the Naval Medical Research Center (NMRC) and the Walter Reed Army Institute of Research (WRAIR) malaria vaccine programs have had six and eight patents granted, respectively. One further WRAIR patent is expected to be assigned a patent number in the coming months. The titles of approved patents are listed below.

U.S. Patent Issue No. 5,095,093 on March 10, 1992

Title: Protective four amino acid epitope against Plasmodium vivax malaria

Inventors: Hoffman, Charoenvit, and Jones

U.S. Patent Issue No. 5,198,535 on March 30, 1993

Title: Protective malaria sporozoite surface protein immunogen and gene

Inventors: Hoffman, Charoenvit, Hedstrom, Khusmith, and Rogers

U.S. Patent Issue No. 5,599,543 on February 4, 1997

Title: Protective four amino acid epitope against Plasmodium vivax malaria

Inventors: Hoffman, Charoenvit, and Jones

U.S. Patent Issue No. 5,814,617 on September 29, 1998

Title: Protective 17 kDa malaria hepatic and erythrocytic stage immunogen and gene

Inventors: Hoffman, Charoenvit, Hedstrom, and Doolan

U.S. Patent Issue No. 6,066,623 on May 23, 2000

Title: Polynucleotide vaccine protective against malaria, methods of protection and vector for delivering polynucleotide vaccines

Inventors: Hoffman, Hedstrom, and Sedegah

U.S. Patent Issue No. 6,399,062 on June 4, 2002

Title: Murine monoclonal antibody protective against Plasmodium vivax malaria

Inventors: Charoenvit, Hoffman, and Beaudoin

U.S. Patent Issue No. 4,906,564 on March 6, 1990

Title: Antigenic determinants recognized by antibodies obtained using a pathogenic agent or derivative thereof that presents a restricted set of antigens

Inventors: Lyon, Chulay, Thomas, Howard, Weber

EUROPEAN PATENT OFFICE Patent Issue No. 0192626 on July 29, 1992

Title: Malaria circumsporozoite vaccine

Inventors: Ballou, Gross, Hockmeyer, Young

GERMAN Patent Issue No. P3686178.2 on July 29, 1992

Title: Malaria circumsporozoite vaccine

Inventors: Ballou, Gross, Hockmeyer, Young

SOUTH AFRICAN Patent Issue No. 86/0874 on December 30, 1996

Title: Malaria circumsporozoite vaccine

Inventors: Ballou, Gross, Hockmeyer, Young

U.S. Patent Issue No. 6,310,046 on October 30, 2001

Title: Sequestrin of Plasmodium falciparum

Inventors: Duffy, Ockenhouse

U.S. Patent Issue No. 6,541,815 on November 4, 2003

Title: Sequestrin

Inventors: Duffy, Ockenhouse

U.S. Patent Issue No. 6,855,322 on February 15, 2005

Title: Isolation and purification of P. falciparum merozoite protein-142 vaccine

Inventors: Lyon, Angov

U.S. Patent Issue No. 7,029,685 on April 18, 2006

Title: Plasmodium falciparum AMA-1 protein and uses thereof

Inventors: Lanar, Dutta, Ware, Nair