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PAPERBACK price:$35.00 add to cart Rights & Permissions Free PDF Access Sign in to download PDF book and chapters Free Resources PDF SUMMARY Display this book on your site! Related Titles Saving Lives, Buying Time: Economics of Malaria Drugs in an Age of Resistance Malaria: Obstacles and Opportunities Other Related Titles Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program (2006) Medical Follow-Up Agency (MFUA) Citation Manager Export the bibliographic data for this book in your chosen format Web Search Builder Use this book's key terms to search within this book, across our collection, or across the Web. Skim This Chapter Skim this chapter and use this chapter's key terms to search within this book. Reference Finder Paste in your own text to find books that relate to your topic. Citation Manager . "Appendix H Open Meeting Agenda." Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press, 2006. Please select a format: Page 110   E-mail Share on facebook Facebook Share on delicious Delicious Share on stumbleupon Stumble Share on twitter Twitter More Sharing ServicesMore The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy. Appendix H Open Meeting Agenda COMMITTEE ON DOD’S MALARIA VACCINE RESEARCH—A PROGRAM REVIEW January 23–25, 2006 Courtyard by Marriott 8506 Fenton St. Silver Spring, MD 20910 Tel 301-589-4899 Meeting Room AGENDA Meeting Objectives Obtain perspectives from DoD on the malaria threat to the force Review DoD’s P. falciparum malaria vaccine research program Review nonmilitary malaria vaccine efforts Develop initial findings and recommendations regarding DoD’s Program Page 110 Front Matter (R1-R22) Summary (1-8) 1 Introduction (9-12) 2 The Malaria Threat and Need for a Vaccine (13-20) 3 Malaria Vaccines (21-40) 4 The U.S. Military Malaria Vaccine Research and Development Program--Scientific Aspects (41-55) 5 Organization and Management of the Program (56-70) References (71-80) Appendix A Vaccine Trials (81-94) Appendix B Current Requirements for a Malaria Vaccine (95-95) Appendix C Suggested Design of Trials for Testing Malaria Vaccines in Nonimmune Adults Visiting Endemic Areas (96-98) Appendix D Patents (99-101) Appendix E Scientific Advisory Board for DoD Malaria Vaccine Research and Development Program (Draft Charter) (102-104) Appendix F Recommendations of the IOM Report Protecting Our Forces (105-106) Appendix G Executive Summary and Recommendations of the DoD Report Acquisition of Vaccine Production (107-109) Appendix H Open Meeting Agenda (110-114) Appendix I Committee and Staff Biographies (115-122)

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OCR for page 110
Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program Appendix H Open Meeting Agenda COMMITTEE ON DOD’S MALARIA VACCINE RESEARCH—A PROGRAM REVIEW January 23–25, 2006 Courtyard by Marriott 8506 Fenton St. Silver Spring, MD 20910 Tel 301-589-4899 Meeting Room AGENDA Meeting Objectives Obtain perspectives from DoD on the malaria threat to the force Review DoD’s P. falciparum malaria vaccine research program Review nonmilitary malaria vaccine efforts Develop initial findings and recommendations regarding DoD’s Program

OCR for page 111
Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program Monday, January 23, 2006 Closed Session 8:00 Bias and Conflict Discussion Susanne Stoiber Executive Director, Institute of Medicine Open Session 9:00 MIDRP Welcome COL David Vaughn, MC Director, Military Infectious Disease Research Program Fort Detrick, Maryland 9:15 Chairman’s Remarks and Introductions 9:30 MIDRP and Malaria Program Overview and Review of Committee Charge COL David Vaughn 10:30 Break 11:00 Overview Malaria Vaccine Development Dr. Filip Dubovsky Scientific Director, Malaria Vaccine Initiative 12:00 Lunch 1:00–5:15 Program Review—Protein-based vaccine strategy 1:00 Objectives and Strategy COL Gray Heppner 1:30 Progress towards an RTS,S-Based Vaccine by Year 2010: New Adjuvants, Antigens, and Vectors Status of RTS,S/AS02A COL Gray Heppner Adjuvant AS01B: RTS,S/AS02A vs. RTS,S/AS01B COL Kent Kester GMP Pf Antigens MSP-1, AMA-1, and LSA-1 Dr. Evelina Angov Adenovirus 35 with circumsporozoite protein Dr. Ann Stewart

OCR for page 112
Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program 2:50 Break 3:00 Clinical Trials of an RTS,S-Based Vaccine COL Gray Heppner 3:30 Future Vaccines Antigen Discovery COL Chris Ockenhouse Vivax COL Chris Ockenhouse Attenuated Knock-out COL Gray Heppner 4:00 Building the RTS,S-Based Vaccine One Allele or Two? COL Chris Ockenhouse The role of molecular analyses Making Development Earlier COL Chris Ockenhouse The potential microarrays Assays of Immune Response Dr. Ann Stewart From robust to validated 4: 30 Barriers from Proof of Concept to Licensure COL Gray Heppner Funding Industrial Partners Licensure Trials 5:00 Discussion 6:30–8:30 Committee Dinner at Redrock Canyon Restaurant, Silver Spring, Maryland

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Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program Tuesday, January 24, 2006 Open Session 8:00–12:30 Program Review—DNA-based vaccine strategy 8:00 Objective, Background & Rationale CAPT Tom Richie 8:30 Program History CAPT Tom Richie 8:50 Functional Elements & Activities Overview CAPT Tom Richie Discovery Research Dr. Denise Doolan Target Antigens Immune Mechanism 9:50 Break (30 minutes) Preclinical Research Dr. Denise Doolan Preclinical Development Dr. Denise Doolan Regulatory Affairs Ms. Gail Levine Clinical Trials LCDR David Regis 11:05 Clinical Development Plan CAPT Tom Richie 11:30 Barriers to Progress CAPT Tom Richie 12:00 Attenuated Sporozoite Vaccine CAPT Tom Richie 12:30 Lunch Closed Executive Session 1:30 Discussion of the DoD program including review of questions posed by the sponsor about the Vaccine Program 5:30–5:45 Chairman’s time 6:30–8:30 Dinner at hotel, local restaurant of choice OR evening working session

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Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program Wednesday, January 25, 2006 Closed Executive Session* 8:00–12:00 Structured discussion of the DoD malaria vaccine research program Clarify gaps or missing information Finish discussions regarding key program questions Develop initial findings and recommendations Establish second meeting date to review report draft. * An open portion of this meeting was posted from 9:00–9:45 and will be honored if needed.

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preventive medicine