Read "Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program" at NAP.edu

Page 110 Cite

Suggested Citation:"Appendix H Open Meeting Agenda." Institute of Medicine. 2006. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press. doi: 10.17226/11656.

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Appendix H
Open Meeting Agenda

COMMITTEE ON DOD’S MALARIA VACCINE RESEARCH—A PROGRAM REVIEW

January 23–25, 2006

Courtyard by Marriott

8506 Fenton St.

Silver Spring, MD 20910

Tel 301-589-4899

Meeting Room

AGENDA

Meeting Objectives

Obtain perspectives from DoD on the malaria threat to the force
Review DoD’s P. falciparum malaria vaccine research program
Review nonmilitary malaria vaccine efforts
Develop initial findings and recommendations regarding DoD’s Program

Page 111 Cite

Suggested Citation:"Appendix H Open Meeting Agenda." Institute of Medicine. 2006. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press. doi: 10.17226/11656.

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Monday, January 23, 2006

Closed Session
8:00	Bias and Conflict Discussion Susanne Stoiber Executive Director, Institute of Medicine
Open Session
9:00	MIDRP Welcome COL David Vaughn, MC Director, Military Infectious Disease Research Program Fort Detrick, Maryland
9:15	Chairman’s Remarks and Introductions
9:30	MIDRP and Malaria Program Overview and Review of Committee Charge COL David Vaughn
10:30	Break
11:00	Overview Malaria Vaccine Development Dr. Filip Dubovsky Scientific Director, Malaria Vaccine Initiative
12:00	Lunch
1:00–5:15	Program Review—Protein-based vaccine strategy
1:00	Objectives and Strategy COL Gray Heppner
1:30	Progress towards an RTS,S-Based Vaccine by Year 2010: New Adjuvants, Antigens, and Vectors Status of RTS,S/AS02A COL Gray Heppner Adjuvant AS01B: RTS,S/AS02A vs. RTS,S/AS01B COL Kent Kester GMP Pf Antigens MSP-1, AMA-1, and LSA-1 Dr. Evelina Angov Adenovirus 35 with circumsporozoite protein Dr. Ann Stewart

Page 112 Cite

Suggested Citation:"Appendix H Open Meeting Agenda." Institute of Medicine. 2006. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press. doi: 10.17226/11656.

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2:50	Break
3:00	Clinical Trials of an RTS,S-Based Vaccine COL Gray Heppner
3:30	Future Vaccines Antigen Discovery COL Chris Ockenhouse Vivax COL Chris Ockenhouse Attenuated Knock-out COL Gray Heppner
4:00	Building the RTS,S-Based Vaccine One Allele or Two? COL Chris Ockenhouse The role of molecular analyses Making Development Earlier COL Chris Ockenhouse The potential microarrays Assays of Immune Response Dr. Ann Stewart From robust to validated
4: 30	Barriers from Proof of Concept to Licensure COL Gray Heppner Funding Industrial Partners Licensure Trials
5:00	Discussion
6:30–8:30	Committee Dinner at Redrock Canyon Restaurant, Silver Spring, Maryland

Page 113 Cite

Suggested Citation:"Appendix H Open Meeting Agenda." Institute of Medicine. 2006. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press. doi: 10.17226/11656.

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Tuesday, January 24, 2006

Open Session
8:00–12:30	Program Review—DNA-based vaccine strategy
8:00	Objective, Background & Rationale CAPT Tom Richie
8:30	Program History CAPT Tom Richie
8:50	Functional Elements & Activities Overview CAPT Tom Richie Discovery Research Dr. Denise Doolan Target Antigens Immune Mechanism
9:50	Break (30 minutes) Preclinical Research Dr. Denise Doolan Preclinical Development Dr. Denise Doolan Regulatory Affairs Ms. Gail Levine Clinical Trials LCDR David Regis
11:05	Clinical Development Plan CAPT Tom Richie
11:30	Barriers to Progress CAPT Tom Richie
12:00	Attenuated Sporozoite Vaccine CAPT Tom Richie
12:30	Lunch
Closed Executive Session
1:30	Discussion of the DoD program including review of questions posed by the sponsor about the Vaccine Program
5:30–5:45	Chairman’s time
6:30–8:30	Dinner at hotel, local restaurant of choice OR evening working session

Page 114 Cite

Suggested Citation:"Appendix H Open Meeting Agenda." Institute of Medicine. 2006. Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program. Washington, DC: The National Academies Press. doi: 10.17226/11656.

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