CI: 22–47 percent). It was encouraging that RTS,S also showed significant protection against severe malaria in children, estimated at 58 percent (95 percent CI: 16–81 percent) in the first six months and 49 percent (95 percent CI: 12–71 percent) over an 18 month period (Alonso et al., 2004, 2005). No significant safety issue associated with RTS,S vaccines was found, although the frequency of some local and systemic adverse effects (e.g., injection site pain, malaise) was increased compared to placebo (Bojang et al., 2005). Protection was not limited to the CSP variants used to make the vaccine (Alloueche et al., 2003).
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3 Malaria Vaccines ."
Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program . Washington, DC: The National Academies Press,
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As of 2013, the National Science Education Standards have been replaced by the Next Generation Science Standards (NGSS), available as a print book, free PDF download, and online with our OpenBook platform.
The NGSS offer a detailed description of the key scientific ideas and practices that all students should learn by the time they graduate from high school. The standards are based largely on the 2011 National Research Council report A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas.