Erythrocytic Stage Vaccines

Peptide

MSP-3/alum or ISA 720

No

Antibody, T cells, interferon

Audran et al., 2005

Recombinant protein

MSP-1/MSP-2 conjugated to diphtheria toxoid

No

Good antibody response; hypersensitivity to diphtheria toxoid

Ramasamy et al., 1995

 

MSP-1/P30P2: two allelic forms of MSP119 plus tetanus toxoid T-cell epitopes

WRAIR

Good antibody response in 14/32

Keitel et al., 1999

 

AMA-1C (3D7 and FVO forms), Pichia pastoris expressed

No

Good antibody response to both forms

Malkin et al., 2005

 

AMA-1/ISA 720

No

Low antibody (vaccine instability)

Saul et al., 2005



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