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Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program Appendix B Current Requirements for a Malaria Vaccine The current requirements for a Plasmodium falciparum vaccine are formulated in a U.S. Army Operational Requirements Document (ORD) dated March 13, 1997, which has now expired and will be replaced by a Capability Development Document (CDD) that is currently (January 2006) in draft. Although these documents have been prepared under the auspices of the U.S. Army, the requirements are no different for the Navy and Marines. The table below shows the requirements as they stand in the expired ORD and the draft CDD. TABLE B-1 Current Operational Requirements for a P. falciparum Malaria Vaccine Attribute Development Threshold Development Objective Efficacy 80% protection 90% protection Time to protection Within 14 days Within 7 days Duration of protection At least 1 year At least 2 years Shelf life At least 2 years At least 3 years Dosing schedule Protection will be attained after two doses Protection will be attained after one dose
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