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OCR for page 99
Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program Appendix D Patents Since 1990, the Naval Medical Research Center (NMRC) and the Walter Reed Army Institute of Research (WRAIR) malaria vaccine programs have had six and eight patents granted, respectively. One further WRAIR patent is expected to be assigned a patent number in the coming months. The titles of approved patents are listed below. NMRC PATENTS GRANTED TO DATE U.S. Patent Issue No. 5,095,093 on March 10, 1992 Title: Protective four amino acid epitope against Plasmodium vivax malaria Inventors: Hoffman, Charoenvit, and Jones U.S. Patent Issue No. 5,198,535 on March 30, 1993 Title: Protective malaria sporozoite surface protein immunogen and gene Inventors: Hoffman, Charoenvit, Hedstrom, Khusmith, and Rogers U.S. Patent Issue No. 5,599,543 on February 4, 1997 Title: Protective four amino acid epitope against Plasmodium vivax malaria Inventors: Hoffman, Charoenvit, and Jones U.S. Patent Issue No. 5,814,617 on September 29, 1998 Title: Protective 17 kDa malaria hepatic and erythrocytic stage immunogen and gene Inventors: Hoffman, Charoenvit, Hedstrom, and Doolan

OCR for page 99
Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program U.S. Patent Issue No. 6,066,623 on May 23, 2000 Title: Polynucleotide vaccine protective against malaria, methods of protection and vector for delivering polynucleotide vaccines Inventors: Hoffman, Hedstrom, and Sedegah U.S. Patent Issue No. 6,399,062 on June 4, 2002 Title: Murine monoclonal antibody protective against Plasmodium vivax malaria Inventors: Charoenvit, Hoffman, and Beaudoin WRAIR PATENTS GRANTED TO DATE U.S. Patent Issue No. 4,906,564 on March 6, 1990 Title: Antigenic determinants recognized by antibodies obtained using a pathogenic agent or derivative thereof that presents a restricted set of antigens Inventors: Lyon, Chulay, Thomas, Howard, Weber EUROPEAN PATENT OFFICE Patent Issue No. 0192626 on July 29, 1992 Title: Malaria circumsporozoite vaccine Inventors: Ballou, Gross, Hockmeyer, Young GERMAN Patent Issue No. P3686178.2 on July 29, 1992 Title: Malaria circumsporozoite vaccine Inventors: Ballou, Gross, Hockmeyer, Young SOUTH AFRICAN Patent Issue No. 86/0874 on December 30, 1996 Title: Malaria circumsporozoite vaccine Inventors: Ballou, Gross, Hockmeyer, Young U.S. Patent Issue No. 6,310,046 on October 30, 2001 Title: Sequestrin of Plasmodium falciparum Inventors: Duffy, Ockenhouse U.S. Patent Issue No. 6,541,815 on November 4, 2003 Title: Sequestrin Inventors: Duffy, Ockenhouse U.S. Patent Issue No. 6,855,322 on February 15, 2005 Title: Isolation and purification of P. falciparum merozoite protein-142 vaccine Inventors: Lyon, Angov

OCR for page 99
Battling Malaria: Strengthening the U.S. Military Malaria Vaccine Program U.S. Patent Issue No. 7,029,685 on April 18, 2006 Title: Plasmodium falciparum AMA-1 protein and uses thereof Inventors: Lanar, Dutta, Ware, Nair