NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This study was supported by the U.S. Army under Grant W911NF-05-1-0089, the U.S. Department of Energy under Grant DE-FG02-04-ER15624, the U.S. Department of Health and Human Services under Grant N01-OD-2139 TO 151, and the National Science Foundation under Grant CHE-0439071.

Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the authors and do not necessarily reflect the views of the organizations or agencies that provided support for the project.