TABLE E.2 Laryngeal Cancer and Exposure to Asbestos—Case-Control Studies

Reference*

Study Population

Exposed Cases

Estimated RR (95% CI)

Berrino et al. 2003

213 male cases of endolaryngeal cancer from six centers in Southern Europe, < 55 years old

 

 

 

Possible

na

1.7 (1.0-3.0)

 

Probable

na

1.8 (0.8-4.0)

 

Combined analysis with 100 hypopharyngeal cancer cases

 

 

 

Asbestos (JEM-derived agent), any exposure

215

1.6 (1.0-2.5)

 

10+ years duration and 20+ years lag

121

1.4 (0.8-2.4)

 

Likelihood of exposure

 

 

 

Possible

175

1.7 (1.1-2.8)

 

Probable

40

1.9 (0.9-3.8)

 

Duration of exposure

 

 

 

< 10 years

na

1.3 (0.6-2.7)

 

10-19 years

na

1.4 (0.7-2.7)

 

≥ 20 years

na

1.7 (0.9-3.0)

p-trend > 0.05

 

Tertiles of weighted exposure

 

 

 

1

na

1.4 (0.8-2.3)

 

2

na

1.9 (1.2-3.2)

 

3

na

1.6 (1.0-2.6)

p-trend = 0.037

Dietz et al. 2003

257 laryngeal cancer cases among residents of Rhein-Neckar region, Germany Asbestos

59

1.3 (0.8-2.1)

Elci et al. 2002

940 laryngeal cancer cases among male residents of Istanbul, Turkey (smoking-adjusted)

 

 

 

Asbestos (JEM-derived agent)

150

1.0 (0.8-1.3)

 

Glottis

28

0.8 (0.5-1.2)

 

Supraglottis

71

1.0 (0.8-1.4)

 

Other laryngeal

51

1.2 (0.9-1.7)

 

Intensity of exposure

 

 

 

Low

45

0.9 (0.6-1.3)

 

Medium

93

1.2 (0.9-1.6)

 

High

12

0.6 (0.3-1.1)

 

Probability of exposure

 

 

 

Low

121

1.2 (0.9-1.5)

 

Medium

20

0.6 (0.4-1.1)

 

High

9

0.7 (0.3-1.5)



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