Berrino et al. 2003

213 male cases of endolaryngeal cancer from six centers in Southern Europe, < 55 years old

Possible

na

1.7 (1.0-3.0)

Probable

na

1.8 (0.8-4.0)

Combined analysis with 100 hypopharyngeal cancer cases

Asbestos (JEM-derived agent), any exposure

215

1.6 (1.0-2.5)

10+ years duration and 20+ years lag

121

1.4 (0.8-2.4)

Likelihood of exposure

Possible

175

1.7 (1.1-2.8)

Probable

40

1.9 (0.9-3.8)

Duration of exposure

< 10 years

na

1.3 (0.6-2.7)

10-19 years

na

1.4 (0.7-2.7)

≥ 20 years

na

1.7 (0.9-3.0)

p-trend > 0.05

Tertiles of weighted exposure

1

na

1.4 (0.8-2.3)

2

na

1.9 (1.2-3.2)

3

na

1.6 (1.0-2.6)

p-trend = 0.037

Dietz et al. 2003

257 laryngeal cancer cases among residents of Rhein-Neckar region, Germany Asbestos

59

1.3 (0.8-2.1)

Elci et al. 2002

940 laryngeal cancer cases among male residents of Istanbul, Turkey (smoking-adjusted)

Asbestos (JEM-derived agent)

150

1.0 (0.8-1.3)

Glottis

28

0.8 (0.5-1.2)

Supraglottis

71

1.0 (0.8-1.4)

Other laryngeal

51

1.2 (0.9-1.7)

Intensity of exposure

Low

45

0.9 (0.6-1.3)

Medium

93

1.2 (0.9-1.6)

High

12

0.6 (0.3-1.1)

Probability of exposure

Low

121

1.2 (0.9-1.5)

Medium

20

0.6 (0.4-1.1)