APPENDIX A
Forum on Microbial Threats
Board on Global Health
Institute of Medicine
The National Academies
Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship
March 16–March 17, 2005
KECK 100
National Academies
500 Fifth Street, N.W.
Washington, D.C. 20001
AGENDA
WEDNESDAY, MARCH 16, 2005
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8:30–9:00 |
Continental Breakfast |
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9:00 |
Welcome and Opening Remarks |
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Stanley Lemon, The University of Texas Medical Branch, Galveston; Chair, Forum on Microbial Threats |
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9:15 |
Arms Races with Evolving Diseases: “We’ve Met the Enemy and He Is Us” |
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Joshua Lederberg, Rockefeller University Stanley Falkow, Stanford University |
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10:15 |
Discussion |
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10:30 |
Break |
Session I: Host-Pathogen Interactions: Defining the Concepts of Pathogenicity, Virulence, Colonization, Commensalism, and Symbiosis
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Moderator: |
P. Frederick Sparling, University of North Carolina Vice-chair, Forum on Microbial Threats |
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10:45 |
Colonization |
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Jeffrey I. Gordon, Washington University School of Medicine, or, Karen Guillemin, University of Washington |
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11:45 |
Discussion |
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12:15 |
Lunch—Welcoming Remarks by Dr. Harvey Fineberg, President, Institute of Medicine |
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1:00–2:30 |
Commensalism and Symbiosis—Host, Microbial, and Environmental Factors |
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Abigail Salyers, University of Illinois, Champaign-Urbana Jo Handelsman, Department of Plant Pathology, University of Wisconsin, Madison |
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2:30–2:45 |
Discussion |
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2:45–3:00 |
Break |
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3:00–4:15 |
Pathogenicity and Virulence |
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Martin Blaser, New York University School of Medicine BJ Staskawicz, University of California, Berkeley |
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4:15–5:45 |
Open Discussion of Day 1 |
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Moderator: |
David Relman, Stanford University |
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Balfor Sartor, University of North Carolina Maria G. Dominguez-Bello, University of Puerto Rico, Rio Piedras |
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5:45 |
Adjournment of the first day |
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6:00 |
Reception |
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7:15 |
Dinner Meeting of the Forum on Microbial Threats [location TBD] |
THURSDAY, MARCH 17, 2005
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8:00–8:30 |
Continental Breakfast |
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8:30 |
Opening Remarks/Summary of Day 1 |
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P. Frederick Sparling, University of North Carolina Vice-chair, Forum on Microbial Threats |
Session II: Ecology of Host-Microbe Interactions
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Moderator: Stephen S. Morse, Columbia University |
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8:40–9:25 |
Endogenous Microbial Communities |
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David Stahl, University of Washington Mark E.J. Woolhouse, Centre for Tropical Veterinary Medicine, University of Edinburgh |
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9:25–10:15 |
How the Host “Sees” and Responds to Pathogens |
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Marian Neutra, Harvard Medical School and Children’s Hospital David Relman, Stanford University |
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10:15–10:30 |
Discussion |
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10:30–10:45 |
Break |
Session III: Understanding the Dynamic Relationships of Host-Microbe Interactions—Discussion Panel
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Moderator: |
David Relman, Stanford University |
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10:45–12:15 |
Lonnie King, Michigan State University Stanley Falkow, Stanford University Jeffrey I. Gordon, Washington University School of Medicine |
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12:15–12:45 |
Lunch |
Session IV: Novel Approaches for Mitigating the Development of Resistance
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Moderator: |
James Hughes, Emory University |
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12:45–1:30 |
Using Pre- and Probiotics to Modify Host-Environmental Factors to Promote Health and Mitigate Disease |
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Michiel Kleerebezem, Holland Suzanne Cunningham-Rundles, Cornell University |
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1:30–2:00 |
Governmental Approaches to Regulating Pre- and Probiotics |
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Lorenzo Morelli, Istituto di Microbiologia UCSC—Italy Julienne Vaillancourt, CBER, FDA |
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2:00–2:15 |
Discussion |
Session V: Challenges and Opportunities to Developing a New Paradigm to Replace the “War Metaphor”
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Moderator: |
Fredrick Sparling, University of North Carolina, Chapel Hill |
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2:15–4:00 With the backdrop of the previous days’ presentations and discussion, Forum members, panel discussants, and the audience will comment on the issues and next steps that they would identify as priority areas for consideration within industry, academia, public health organizations, and other government sectors. The discussion of priorities will summarize the issues surrounding emerging opportunities for more effective collaboration as well as the remaining research and programmatic needs. The confounding issues of the major obstacles to preparing an optimal response, particularly as it relates to the complexities of interaction between private industry, research and public health agencies, regulatory agencies, policy makers, academic researchers, and the public, will be explored with an eye toward innovative responses to such challenges. |
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Panel Discussants: |
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Joshua Lederberg, Rockefeller University David Stahl, University of Washington |
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4:00 |
Adjourn |
