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Suggested Citation:"APPENDIX B Acronyms." Institute of Medicine. 2006. Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11669.
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APPENDIX B
Acronyms


ACE-ART

Assessment and Critical Evaluation of Antibiotic Resistance Transferability

AFSSA

French Food Safety Authority

AIDS

acquired immunodeficiency syndrome

AOM

azoxymethane


BLA

biologics license application


CBER

Center for Biologics Evaluation and Research

CDC

Centers for Disease Control and Prevention

CFB

Cytophaga-Flavobacterium-Bacteroides

CFR

Code of Federal Regulations

CFSAN

Center for Food Safety and Applied Nutrition

CLL

chronic lymphocytic leukemia

CMC

chemistry, manufacturing, and controls

CONV-R

conventionally raised

CPS

capsular polysaccharide synthesis


DGGE

denaturing gradient gel electrophoresis

DLCL

diffuse large B-cell lymphomas

DNA

deoxyribonucleic acid

DPF

day post-fertilization

DSHEA

Dietary Supplement Health and Education Act

DSS

dextran sodium sulfate

Suggested Citation:"APPENDIX B Acronyms." Institute of Medicine. 2006. Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11669.
×

ESPGHAN

European Society for Paediatric Gastroenterology Hepatology and Nutrition


FAE

follicle-associated epithelium

FAO

Food and Agriculture Organization

FDA

Food and Drug Administration

Fiaf

fastin-induced adipocyte factor

FISH

fluorescent in-situ hybridization

FLS

flagellin sensitivity


GALT

gut-associated lymphoid tissue

GBBS

Group B beta-hemolytic Streptococcus

GE

gastroesophageal

GERD

gastroesophageal reflux disease

GF

germ-free

GI

gastrointestinal

GPI

glycosylphatidylinositol

GRAS

generally recognizable as safe


HAART

highly active antiretroviral therapy

HIV

human immunodeficiency virus

HLA

human lymphocyte antigen


IBD

inflammatory bowel disease

IgA

immunoglobulin A

IgG

immunoglobulin G

IFN

interferon

IL

interleukin

IND

investigational new drug

IOM

Institute of Medicine

ISAPP

International Scientific Association for Probiotics and Prebiotics

IVET

in vivo expression technology


LPL

lipoprotein lipase

LPS

lipopolysaccharide

LRR-TM

leucine-rich repeat transmembrane


MALT

mucosa-associated lymphoid tissue

MEMS

microelectromechanical systems


NBS LRR

nucleotide-binding site plus leucine-rich repeat

NCBI

National Centre for Biotechnology Information

Suggested Citation:"APPENDIX B Acronyms." Institute of Medicine. 2006. Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11669.
×

NK

natural killer

NSAID

nonsteroidal anti-inflammatory drug


OCTN

organic cation transporter genes

OVRR

Office of Vaccine Research and Review


PBMC

peripheral blood mononuclear cell

PCR

polymerase chain reaction

PRR

pattern recognition receptor


qRT

quantitative reverse transcription


RNA

ribonucleic acid

RPM

Resistance to P. syringae pv maculicola

RPS

Resistance to P. syringae


SARS

severe acute respiratory syndrome

SCID

severe combined immune deficient

SCOTS

selective capture of transcribed sequences

SLOTU

species-level operational taxonomic unit

SPF

specific pathogen free

STM

signature-tagged mutagenesis


T-DNA

transfer DNA

TGF

transforming growth factor

Th

T helper

TLR

toll-like receptor

TMV

tobacco mosaic virus


VTEC

verocytotoxigenic E. coli


WB

whole blood

WHO

World Health Organization

Suggested Citation:"APPENDIX B Acronyms." Institute of Medicine. 2006. Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11669.
×
Page 265
Suggested Citation:"APPENDIX B Acronyms." Institute of Medicine. 2006. Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11669.
×
Page 266
Suggested Citation:"APPENDIX B Acronyms." Institute of Medicine. 2006. Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/11669.
×
Page 267
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 Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship: Workshop Summary
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Infectious diseases have existed longer than us, as long as us, or are relatively newer than us. It may be the case that a disease has existed for many, many years but has only recently begun affecting humans. At the turn of the century the number of deaths caused by infections in the United States had been falling steadily but since the '80s has seen an increase. In the past 30 years alone 37 new pathogens have been identified as human disease threats and 12% of known human pathogens have been classified as either emerging or remerging. Whatever the story, there is currently a "war" on infectious diseases. This war is simply the systematic search for the microbial "cause" of each disease, followed by the development of antimicrobial therapies.

The "war" on infectious diseases, however, must be revisited in order to develop a more realistic and detailed picture of the dynamic interactions among and between host organisms and their diverse populations of microbes. Only a fraction of these microbes are pathogens. Thus, in order to explore the crafting of a new metaphor for host-microbe relationships, and to consider how such a new perspective might inform and prioritize biomedical research, the Forum on Microbial Threats of the Institute of Medicine (IOM) convened the workshop, Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship on March 16-17, 2005.

Workshop participants examined knowledge and approaches to learning about the bacterial inhabitants of the human gut, the best known host-microbe system, as well as findings from studies of microbial communities associated with other mammals, fish, plants, soil, and insects. The perspective adopted by this workshop is one that recognizes the breadth and diversity of host-microbe relationships beyond those relative few that result in overt disease. Included in this summary are the reports and papers of individuals participating in the Forum as well as the views of the editors.

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