cornerstones of the “toxic” environment. That is, increased consumption of fast foods has been associated with increased weight status. Among 891 adults enrolled in the “Pound of Prevention Study,” greater frequency of eating fast foods was significantly associated with higher total energy intake, higher percent fat intake, more frequent consumption of hamburgers, french fries, and soft drinks, and less frequent consumption of fiber and fruit. Over 3 years, each additional fast-food meal/week was associated with an excess weight gain of 0.72 kg beyond the average weight gain observed during that period. In a prospective study of over 3,000 young adults enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study, frequency of fast-food restaurant visits at baseline (visits/week) predicted excess 15-year weight gain and worsening of insulin resistance in Caucasian and African American respondents [108].

Visiting fast-food restaurants may promote obesity by promoting increased consumption of energy-dense foods. Prentice and Jebb [109] reviewed the nutritional content of the foods sold at three popular fast-food outlets. The average energy densities for the three menus were 1.7-fold greater than the average British diet. Other potential mechanisms by which fast-food restaurants may promote a positive energy balance include the increased portion sizes of foods (e.g., “super-sizing”).

In conclusion, fast-food establishments may put certain individuals at an increased risk for the overconsumption of calories. As noted in Section 7, additional research is needed to test whether certain obesity-promoting genotypes moderate this association (i.e., a gene-environment interaction) or whether individuals with certain genotypes may be more likely to seek out such restaurants (i.e., a gene-environment correlation).

4b.
Physical Activity and Sedentary Behavior

Living in the modern-day environment has decreased the need for individuals to be physically active. Decreased physical activity, and thus decreased energy expenditure, has been negatively associated with BMI [110-112] and maintenance of weight loss [68, 113]. The following two sections will highlight two activity-related activities in particular. One is television viewing and its association with weight status, the other is nonexercise activity thermogenesis (NEAT).

i.
Television Viewing

Increased television viewing (TVV) has been associated with increased energy intake and body weight [114]. The mechanisms for this association



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