cancer. The committee recommends that toxicologic data be used to fit the primary dose-response model(s) and that the available epidemiologic data be used only for validation. The committee does not believe that the available information is sufficient to determine the best dose-response model for trichloroethylene. The default linear extrapolation procedure suggested in the EPA cancer risk assessment guidance can be applied but should first be explicitly defined.
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12 Issues in the Assessment of Dose Response ."
Assessing the Human Health Risks of Trichloroethylene: Key Scientific Issues . Washington, DC: The National Academies Press,
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