served as Chair of the Clinical Steering Committee for the Pharmaceutical Research and Manufacturers Association (PhRMA). A Fellow of the American College of Epidemiology, and former Vice-Chair of the American Board of Preventive Medicine, Dr. Tilson also served as President of the American College of Preventive Medicine from 1995 to 1997. A founding member of the American Academy of Pharmaceutical Physicians, now the Academy of Pharmaceutical Physicians and Investigators (APPI), he is APPI Vice-President for Policy. Dr. Tilson has served as a member of seven IOM committees, and served as Chair of the Committee on Post-market Surveillance of Pediatric Medical Devices.


Apinun Aramrattana, M.D., Ph.D., is a medical epidemiologist and a leading drug use researcher in Thailand. He is the Deputy Director of the Research Institute of Health Sciences and also the Director of the Northern Substance Abuse Center at Chiang Mai University. Dr. Apinun has been one of the principal researchers who organized the first and second national household surveys of drug use in Thailand in 2001 and 2003. He is the Thailand Principal Investigator on a number of National Institutes of Health (NIH)-supported HIV prevention trials for injection drug users and methamphetamine-using youth, and he is directing a study for the HIV Prevention Trials Network on buprenorphine/naloxone substitution maintenance therapy vs. buprenorphine/naloxone detoxification as an HIV prevention strategy. He also works closely with relevant narcotics control agencies to facilitate policy-relevant research and development projects.


Samuel A. Bozzette, M.D., Ph.D., is Senior Natural Scientist at The RAND Corporation and Adjunct Professor of Medicine (Infectious Diseases) and of International Relations at the University of California (UC) San Diego. He is board-certified in Internal Medicine and Infectious Diseases, and is a Fellow of the American College of Physicians and the Infectious Diseases Society of America. He has a long record of clinical, translational, outcomes, and health economics research, resulting in over 125 scientific publications in universally respected journals and three dozen chapters, reports, and editorials. He headed the Opportunistic Infections and later the Outcomes working groups for the National Institute of Allergy and Infectious Disease’s (NIAID’s) AIDS Clinical Trials Group and was a leader in the California Collaborative Treatment Group. He has been a Principal Investigator for many large research projects, such as the nationally representative HIV Cost and Services Utilization Study. He founded the Center for Research in Patient-Oriented Care at the Veteran Affairs (VA) San Diego and did seminal work in modeling of potential bioterrorist attacks. Dr. Bozzette is involved in teaching clinical and research skills, and co-directs a training program in Public Policy and Biologic Threats for the



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