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The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy. THE NATIONAL ACADEMIES PRESS 500 Fifth Street, N.W. Washington, DC 20001 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This study was supported by Contract No. 223-01-2460, Task Order No. 23; HHSP23320042509XI, Task Order No. 3; and HHSM-500-2005-00026C between the National Academy of Sciences and the Department of Health and Human Services (the Food and Drug Administration, the Agency for Healthcare Research and Quality, the Centers for Medicaid and Medicare Services, the National Institutes of Health), and the United States Department of Veterans Affairs. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project. Library of Congress Cataloging-in-Publication Data Institute of Medicine (U.S.). Committee on the Assessment of the US Drug Safety System. The future of drug safety : promoting and protecting the health of the public / Committee on the Assessment of the US Drug Safety System, Board on Population Health and Public Health Practice ; Alina Baciu, Kathleen Stratton, Sheila P. Burke, editors. p. ; cm. Includes bibliographical references. ISBN 978-0-309-10304-6 (pbk.) 1. Pharmaceutical policy—United States. 2. United States. Food and Drug Administration. 3. Drugs—Safety measures—United States. I. Baciu, Alina. II. Stratton, Kathleen R. III. Burke, Sheila P. IV. Title. [DNLM: 1. United States. Food and Drug Administration. 2. Drug Approval—United States. 3. United States Government Agencies—United States. QV 771 I5852f 2007] RA401.A3.I568 2007 362.17′82—dc22 2006039224 Additional copies of this report are available from the National Academies Press, 500 Fifth Street, N.W., Lockbox 285, Washington, DC 20055; (800) 624-6242 or (202) 334-3313 (in the Washington metropolitan area); Internet, http://www.nap.edu. For more information about the Institute of Medicine, visit the IOM home page at: www.iom.edu. Copyright 2007 by the National Academy of Sciences. All rights reserved. Printed in the United States of America. The serpent has been a symbol of long life, healing, and knowledge among almost all cultures and religions since the beginning of recorded history. The serpent adopted as a logotype by the Institute of Medicine is a relief carving from ancient Greece, now held by the Staatliche Museen in Berlin.
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