TABLE 2.1 Design of Epidemiology Studies of ALS in US Veterans

Reference

Study Population

Comparison Population

At Risk N (ALS cases)

Reference N (ALS cases)

Study Design

Case-Ascertainment Methods

Analysis

Risk Ratios (95% Confidence Intervals)

Smith et al. 2000

All active, gulf-deployed military personnel who served during the Gulf War (August 8, 1990–July 31, 1991)

Non-gulf-deployed Gulf War-era veterans

551,841 (6)

1,478,704 (12)

Cohort followup, August 1991-July 1997

DOD hospitalization records

Cox proportional—hazards analysis

1.66(0.62–4.44); adjusted for age

Kang and Bullman 2001

Active, gulf-deployed military personnel who served during the Gulf War (August 8, 1990–March 1, 1991)

Non-gulf-deployed Gulf War-era veterans

621,902 (NA)

746,248 (NA)

Cohort followup, May 1991–December 1997

Database records of VA and Social Security Administration

Cox proportional-hazards analysis

0.59 (0.21–1.66); adjusted for age, race, sex, marital status, brach of service, unit component



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