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Seafood Choices: Balancing Benefits and Risks
Evaluating preschool and school-age children exposed to EPA/ DHA in utero and postnatally, at ages beginning around 4 years when executive function is more developed; and
Evaluating development of school-age children exposed to variable EPA/DHA levels in utero and postnatally with measures of distractibility, disruptive behavior, and oppositional defiant behavior, as well as more commonly assessed cognitive outcomes and more sophisticated tests of visual function.
Recommendation 7: Additional data are needed to better define optimum intake levels of EPA/DHA for infants and toddlers.
Recommendation 8: Better-designed studies about EPA/DHA supplementation in children with behavioral disorders are needed.
Adults at Risk for Chronic Disease
Recommendation 9: In the absence of meta-analyses that systematicallycombine quantitative data from multiple studies, further meta-analyses andlarger randomized trials are needed to assess outcomes other than cardiovascular, in particular total mortality, in order to explore possible adverse effects of EPA/DHA supplementation.
Recommendation 10: Additional clinical research is needed to assess apotential effect of seafood consumption and/or EPA/DHA supplementationon stroke, cancer, Alzheimer’s disease, and depression.
Recommendation 11: Future epidemiological studies should assess intake of specific species of seafood and/or biomarkers, in order to differentiate the health effects of EPA/DHA from the health effects of contaminantssuch as methylmercury.
Health Risks Associated with Seafood Consumption
Recommendation 12: More complete data are needed on the distribution of contaminant levels among types of fish. This information should be made available in order to reduce uncertainties associated with the estimation of health risks for specific seafoodborne contaminant exposures.
Recommendation 13: More quantitative characterization is neededof the dose-response relationships between chemical contaminants andadverse health effects, in the ranges of exposure represented in the generalUS population. Such information will reduce uncertainties associated with recommendations for acceptable ranges of intake.