Studies on Women, Infants, and Children

TABLE B-1a Studies on Preeclampsia: Effects on Women Who Increase Seafood and/or Omega-3 Fatty Acid Intake


Study Type



Timing of Exposure

Sibai, 1998


3 randomized controlled trials

Fish-oil supplement


Sindelar et al., 2004

Randomized Controlled Trial

Men (n=8)

Women (n=4)

Mean age of 33 years

Lincoln, NE

Non-Hispanic White

Recruited at YMCA marathon and triathlon training group meetings and word of mouth

Exercising regularly as members of a running training group sponsored by the local YMCA

No being treated with eating disorders or depression, or those unable to eat eggs, or those using medications known to affect serum lipids

n-3 PUFA-enriched eggs

2 weeks baseline period, 4 weeks treatment period (crossover design), 4 weeks washout period between treatments

Haugen and Helland, 2001

Randomized Controlled Trial

Pregnant women (n=37)

Mean age about 27-31 years

Oslo, Norway

Normotensive without proteinuria, had uncomplicated term pregnancies, randomly taken from another study investigating the influence of omega-3 fatty acids on fetal, neonatal, and child development

Another group had moderate preeclampsia

Cod-liver oil supplement

16-20 weeks gestation through pregnancy

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