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Semipurified diet:
Deficient in n-3 fatty acids
Safflower oil was sole fat source
High n-6:n-3 ratio
Controls:
Soybean oil was sole fat source
High in LA
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At all ages, animals of the “deficient group had considerably lower levels of n-3 fatty acids in tissue phospholipids than their controls.”
Based on the occipital cortex, perinatal 22:5n-6 (p<0.01) and total n-6 (p<0.05) were significantly higher and perinatal DHA (p<0.01) and total n-3 (p<0.01) were significantly lower in the deficient group compared to the control group.
Based on the occipital cortex, 22:4n-6 (p<0.01), 22:5n-6 (p<0.01), and total n-6 (p<0.01) at 22 months were significantly higher and DHA (p<0.01) and total n-3 (p<0.01) at 22 months were significantly lower in the deficient group compared to the control group.
Based on the frontal cortex, perinatal 22:5n-6 (p<0.01) was significantly higher and perinatal DHA (p<0.01) and total n-3 (p<0.01) were significantly lower in the deficient group compared to the control group.
Based on the frontal cortex, 22:5n-6 (p<0.01) and total n-6 (p<0.01) at 22 months were significant higher and DHA (p<0.01) and total n-3 (p<0.01) at 22 months were significantly lower in the deficient group compared to the control group.
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N/A
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