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Cord blood (percentages of total red blood cell membrane phospholipid):
Medians: 0.02 ALA, 0.11 EPA, 0.22 DPA, 2.00 DHA, 4.65 LA, and 7.80 AA
Maternal blood (percentages of total red blood cell membrane phospholipid):
Medians: 0.14 ALA, 0.23 EPA, 0.60 DPA, 2.02 DHA, 11.46 LA, and 5.88 AA
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After controlling for sex, gestational age at birth, birth weight, mother’s age, education level, housing tenure, parity, ethnicity, smoking in pregnancy, maternal atopic disease, child’s head circumference at birth, child’s crown to heel length at birth, mother’s BMI, breastfeeding in first 6 months, and day care use in first 6 months:
All associations between fatty acid exposure (based on cord blood levels and maternal blood levels) and eczema at 18 to 30 months were found to be nonsignificant;
All associations between fatty acid exposure (based on both cord blood levels and maternal blood levels) and wheezing at 30 to 42 months of age were found to be nonsignificant;
LA:ALA levels in cord blood were significantly associated with later-onset wheeze (OR=1.30, 95% CI 1.04-1.61), as was the ratio of ALA:sum of n-3 products (OR=0.86, 95% CI 0.75-0.99); and
No other significant associations were found between fatty acid exposure and transient infant wheeze, later-onset wheeze, or persistent wheeze.
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