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“Neither [systolic or diastolic blood pressure] were significantly affected by omega-3 supplementation” (SBP mean difference = 1.03 mmHg, 95% CI −3.30 to 1.25, p=0.18; DBP mean difference = −0.23 mmHg, 95% CI 1.10-0.64, p=0.92).
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N
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Doses of fish oil:
<1.0 g/day in 1 trial
1.0-1.9 g/day in 5 trials
2.0-2.9 g/day in 4 trials
3.0-15.0 g/day in 26 trials
mean dose = 3.7 g/day
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In the univariate analysis:
Based on all trials, fish oil decreased SBP and DBP significantly more among those >45 years of age compared to those ≤45 years of age (p=0.023 for SBP and p=0.020 for DBP) and in those with hypertension compared to those without hypertension (p=0.008 for SBP and p=0.041 for DBP). Fish oil also decreased SBP and DBP more in populations with males and females compared to those with only males and among those with a BMI >26.8kg/m2 compared to those with BMI ≤26.8 kg/m2, but the differences were not significant; and
Based on double-blinded trials, fish oil decreased SBP and DBP significantly more among those with hypertension compared to those without hypertension (p=0.005 for SBP and p=0.010 for DBP). Fish oil also decreased SBP and DBP more among those >45 years of age compared to those ≤45 years of age; in populations with males and females compared to those with only males, and among those with a BMI >26.8kg/m2 compared to those with BMI ≤26.8 kg/m2, but the differences were not significant.
After adjusting for age, percent males, baseline BP, study design, and fish oil dose:
Fish oil decreased SBP and DBP more among those >45 years of age compared to those ≤45 years of age, in populations with males and females compared to those with only males, in those with hypertension compared to those without hypertension, and among those with a BMI >26.8kg/m2 compared to those with BMI ≤26.8 kg/m2, but the differences were not significant.
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N
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