Amount

Results

Conclusion*

 

“Neither [systolic or diastolic blood pressure] were significantly affected by omega-3 supplementation” (SBP mean difference = 1.03 mmHg, 95% CI −3.30 to 1.25, p=0.18; DBP mean difference = −0.23 mmHg, 95% CI 1.10-0.64, p=0.92).

N

Doses of fish oil:

<1.0 g/day in 1 trial

1.0-1.9 g/day in 5 trials

2.0-2.9 g/day in 4 trials

3.0-15.0 g/day in 26 trials

mean dose = 3.7 g/day

In the univariate analysis:

Based on all trials, fish oil decreased SBP and DBP significantly more among those >45 years of age compared to those ≤45 years of age (p=0.023 for SBP and p=0.020 for DBP) and in those with hypertension compared to those without hypertension (p=0.008 for SBP and p=0.041 for DBP). Fish oil also decreased SBP and DBP more in populations with males and females compared to those with only males and among those with a BMI >26.8kg/m2 compared to those with BMI ≤26.8 kg/m2, but the differences were not significant; and

Based on double-blinded trials, fish oil decreased SBP and DBP significantly more among those with hypertension compared to those without hypertension (p=0.005 for SBP and p=0.010 for DBP). Fish oil also decreased SBP and DBP more among those >45 years of age compared to those ≤45 years of age; in populations with males and females compared to those with only males, and among those with a BMI >26.8kg/m2 compared to those with BMI ≤26.8 kg/m2, but the differences were not significant.

After adjusting for age, percent males, baseline BP, study design, and fish oil dose:

Fish oil decreased SBP and DBP more among those >45 years of age compared to those ≤45 years of age, in populations with males and females compared to those with only males, in those with hypertension compared to those without hypertension, and among those with a BMI >26.8kg/m2 compared to those with BMI ≤26.8 kg/m2, but the differences were not significant.

N



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